Tags

Type your tag names separated by a space and hit enter

Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice.
Front Aging Neurosci 2019; 11:168FA

Abstract

Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with inflammation and immunogenic responses in the central and peripheral systems by the activation of the B1 and B2 receptors. Previous work by our group showed that bradykinin (BK) and the B2 receptor played a possible role in neuroprotection. Therefore, the objective of this study was to evaluate the participation of B2 receptors in cell viability, neuroinflammatory response and neuroplasticity in organotypic hippocampal cultures (OHCs) of 6- and 12-month-old mice. It was observed that activation of the B2 receptor by bradykinin decreased the inflammatory response and increased plasticity in 12-month-old slices. Conversely, there was an increase in the inflammatory response and a decrease in neural plasticity in the 6-month-old slices. In both ages, an increase in cell viability was observed. This data suggests that the function of the kinin B2 receptor in the hippocampus is modulated by age, providing neuroprotective action in old age.

Authors+Show Affiliations

Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil. Research Group on Neuropharmacology of Aging-ReGNA, São Paulo, Brazil.Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil. Research Group on Neuropharmacology of Aging-ReGNA, São Paulo, Brazil.Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.Research Group on Neuropharmacology of Aging-ReGNA, São Paulo, Brazil. School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil. Research Group on Neuropharmacology of Aging-ReGNA, São Paulo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31354470

Citation

Toricelli, Mariana, et al. "Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice." Frontiers in Aging Neuroscience, vol. 11, 2019, p. 168.
Toricelli M, Evangelista SR, Oliveira LR, et al. Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice. Front Aging Neurosci. 2019;11:168.
Toricelli, M., Evangelista, S. R., Oliveira, L. R., Viel, T. A., & Buck, H. S. (2019). Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice. Frontiers in Aging Neuroscience, 11, p. 168. doi:10.3389/fnagi.2019.00168.
Toricelli M, et al. Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice. Front Aging Neurosci. 2019;11:168. PubMed PMID: 31354470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice. AU - Toricelli,Mariana, AU - Evangelista,Sebastiana Ribeiro, AU - Oliveira,Larissa Rolim, AU - Viel,Tania Araujo, AU - Buck,Hudson Sousa, Y1 - 2019/07/12/ PY - 2019/04/24/received PY - 2019/06/17/accepted PY - 2019/7/30/entrez PY - 2019/7/30/pubmed PY - 2019/7/30/medline KW - Alzheimer’s disease KW - bradykinin KW - kallikrein-kinin system KW - neuroinflammation KW - organotypic culture SP - 168 EP - 168 JF - Frontiers in aging neuroscience JO - Front Aging Neurosci VL - 11 N2 - Aging is a multifactorial phenomenon that results in several changes at cellular and molecular levels and is considered the main risk factor for some neurodegenerative diseases. Several evidence show the participation of the kallikrein-kinin system (KKS) in neurodegeneration and this system has been associated with inflammation and immunogenic responses in the central and peripheral systems by the activation of the B1 and B2 receptors. Previous work by our group showed that bradykinin (BK) and the B2 receptor played a possible role in neuroprotection. Therefore, the objective of this study was to evaluate the participation of B2 receptors in cell viability, neuroinflammatory response and neuroplasticity in organotypic hippocampal cultures (OHCs) of 6- and 12-month-old mice. It was observed that activation of the B2 receptor by bradykinin decreased the inflammatory response and increased plasticity in 12-month-old slices. Conversely, there was an increase in the inflammatory response and a decrease in neural plasticity in the 6-month-old slices. In both ages, an increase in cell viability was observed. This data suggests that the function of the kinin B2 receptor in the hippocampus is modulated by age, providing neuroprotective action in old age. SN - 1663-4365 UR - https://www.unboundmedicine.com/medline/citation/31354470/Neuroprotective_Effects_of_Kinin_B2_Receptor_in_Organotypic_Hippocampal_Cultures_of_Middle-Aged_Mice L2 - https://doi.org/10.3389/fnagi.2019.00168 DB - PRIME DP - Unbound Medicine ER -