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'On-off' phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma.
Neurology. 1988 Aug; 38(8):1245-8.Neur

Abstract

Administration of a low-protein diet to parkinsonian patients with "on-off" syndromes consistently increased the total daily time of "on" states when compared with a high-protein diet. The clinical effect of the low-protein diet may be due to a marked decrease in the plasma concentration of large neutral amino acids that compete with L-dopa for carrier-mediated transport into the brain.

Authors+Show Affiliations

Department of Pharmacology, University of Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3135513

Citation

Eriksson, T, et al. "'On-off' Phenomenon in Parkinson's Disease: Relationship Between Dopa and Other Large Neutral Amino Acids in Plasma." Neurology, vol. 38, no. 8, 1988, pp. 1245-8.
Eriksson T, Granérus AK, Linde A, et al. 'On-off' phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology. 1988;38(8):1245-8.
Eriksson, T., Granérus, A. K., Linde, A., & Carlsson, A. (1988). 'On-off' phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology, 38(8), 1245-8.
Eriksson T, et al. 'On-off' Phenomenon in Parkinson's Disease: Relationship Between Dopa and Other Large Neutral Amino Acids in Plasma. Neurology. 1988;38(8):1245-8. PubMed PMID: 3135513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 'On-off' phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. AU - Eriksson,T, AU - Granérus,A K, AU - Linde,A, AU - Carlsson,A, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 1245 EP - 8 JF - Neurology JO - Neurology VL - 38 IS - 8 N2 - Administration of a low-protein diet to parkinsonian patients with "on-off" syndromes consistently increased the total daily time of "on" states when compared with a high-protein diet. The clinical effect of the low-protein diet may be due to a marked decrease in the plasma concentration of large neutral amino acids that compete with L-dopa for carrier-mediated transport into the brain. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/3135513/'On_off'_phenomenon_in_Parkinson's_disease:_relationship_between_dopa_and_other_large_neutral_amino_acids_in_plasma_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3135513.ui DB - PRIME DP - Unbound Medicine ER -