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[Quality evaluation of Moutan Cortex Formula Granules].
Zhongguo Zhong Yao Za Zhi. 2019 May; 44(10):2065-2071.ZZ

Abstract

A scientific and perfect quality evaluation system for Moutan Cortex Formula Granules was established,including content determination method,characteristic chromatogram method and mass spectrometry method. The content of paeoniflorin and paeonol in Moutan Cortex Formula Granules was determined by high performance liquid chromatography(HPLC),and the average content was 1. 72% and 1. 42%,respectively. The characteristic chromatogram was used to characterize Moutan Cortex Formula Granules,which contained 7 characteristic peaks,namely gallic acid,p-hydroxybenzoic acid,oxypaeoniflorin,paeoniflorin,tetragalloyl glucose,1,2,3,4,6-penta-O-galloyl-β-D-glucose and paeonol. A total of 40 compounds in Moutan Cortex Formula Granules,including gallic acids,paeoniflorins,paeonols,flavonoids and benzoic acids,were identified by mass spectrometry. In this study,a variety of analytical methods were used to evaluate the quality system of Moutan Cortex Formula Granules,which could play a positive role in improving the level of quality evaluation and process quality control.

Authors+Show Affiliations

National Resource Center of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China Center for Post-doctoral Research,China Academy of Chinese Medical Sciences Beijing 100700,China Anhui Jiuzhou Fangyuan Pharmaceutical Co.,Ltd. Bozhou 236800,China.College of Pharmaceutical Sciences,Zhejiang University of Technology Hangzhou 310014,China.College of Pharmaceutical Sciences,Zhejiang University of Technology Hangzhou 310014,China.College of Pharmaceutical Sciences,Zhejiang University of Technology Hangzhou 310014,China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

31355562

Citation

DU, Xin-Gang, et al. "[Quality Evaluation of Moutan Cortex Formula Granules]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 44, no. 10, 2019, pp. 2065-2071.
DU XG, Jiang HJ, Zhang H, et al. [Quality evaluation of Moutan Cortex Formula Granules]. Zhongguo Zhong Yao Za Zhi. 2019;44(10):2065-2071.
DU, X. G., Jiang, H. J., Zhang, H., & Yan, J. Z. (2019). [Quality evaluation of Moutan Cortex Formula Granules]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 44(10), 2065-2071. https://doi.org/10.19540/j.cnki.cjcmm.20181224.002
DU XG, et al. [Quality Evaluation of Moutan Cortex Formula Granules]. Zhongguo Zhong Yao Za Zhi. 2019;44(10):2065-2071. PubMed PMID: 31355562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Quality evaluation of Moutan Cortex Formula Granules]. AU - DU,Xin-Gang, AU - Jiang,Hui-Jie, AU - Zhang,Hui, AU - Yan,Ji-Zhong, PY - 2019/7/30/entrez PY - 2019/7/30/pubmed PY - 2019/9/13/medline KW - Formula Granules KW - Moutan Cortex KW - characteristic chromatogram KW - content determination KW - mass spectrometry KW - paeoniflorin KW - paeonol SP - 2065 EP - 2071 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 44 IS - 10 N2 - A scientific and perfect quality evaluation system for Moutan Cortex Formula Granules was established,including content determination method,characteristic chromatogram method and mass spectrometry method. The content of paeoniflorin and paeonol in Moutan Cortex Formula Granules was determined by high performance liquid chromatography(HPLC),and the average content was 1. 72% and 1. 42%,respectively. The characteristic chromatogram was used to characterize Moutan Cortex Formula Granules,which contained 7 characteristic peaks,namely gallic acid,p-hydroxybenzoic acid,oxypaeoniflorin,paeoniflorin,tetragalloyl glucose,1,2,3,4,6-penta-O-galloyl-β-D-glucose and paeonol. A total of 40 compounds in Moutan Cortex Formula Granules,including gallic acids,paeoniflorins,paeonols,flavonoids and benzoic acids,were identified by mass spectrometry. In this study,a variety of analytical methods were used to evaluate the quality system of Moutan Cortex Formula Granules,which could play a positive role in improving the level of quality evaluation and process quality control. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/31355562/[Quality_evaluation_of_Moutan_Cortex_Formula_Granules]_ DB - PRIME DP - Unbound Medicine ER -