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Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress.
J Cardiovasc Pharmacol. 2019 10; 74(4):326-335.JC

Abstract

Heart failure characterized by cardiac remodeling is a global problem. Angiotensin II (Ang II) induces cardiac inflammation and oxidative stress, which also is implicated in the pathophysiology of adverse collagen accumulation-induced remodeling. Kaempferol (KPF), a kind of flavonoid compounds, is capable of anti-inflammatory and antioxidant activities. However, the target of KPF still remains blurred. In this study, we investigated the effect of KPF on Ang II-induced collagen accumulation and explored the underlying mechanisms. Our results suggested that KPF prevented Ang II-induced cardiac fibrosis and dysfunction, in mice challenged with subcutaneous injection of Ang II. In culture cells, KPF significantly reduced Ang II-induced collagen accumulation. Furthermore, KPF remarkably decreased inflammation and oxidative stress in Ang II-stimulated cardiac fibroblasts by modulating NF-κB/mitogen-activated protein kinase and AMPK/Nrf2 pathways.

Authors+Show Affiliations

Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Cardiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.Department of Cardiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.Department of Cardiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31356553

Citation

Du, Yao, et al. "Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress." Journal of Cardiovascular Pharmacology, vol. 74, no. 4, 2019, pp. 326-335.
Du Y, Han J, Zhang H, et al. Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress. J Cardiovasc Pharmacol. 2019;74(4):326-335.
Du, Y., Han, J., Zhang, H., Xu, J., Jiang, L., & Ge, W. (2019). Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress. Journal of Cardiovascular Pharmacology, 74(4), 326-335. https://doi.org/10.1097/FJC.0000000000000713
Du Y, et al. Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress. J Cardiovasc Pharmacol. 2019;74(4):326-335. PubMed PMID: 31356553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress. AU - Du,Yao, AU - Han,Jibo, AU - Zhang,Haixia, AU - Xu,Jianjiang, AU - Jiang,Liqin, AU - Ge,Weihong, PY - 2019/7/30/pubmed PY - 2020/6/24/medline PY - 2019/7/30/entrez SP - 326 EP - 335 JF - Journal of cardiovascular pharmacology JO - J Cardiovasc Pharmacol VL - 74 IS - 4 N2 - Heart failure characterized by cardiac remodeling is a global problem. Angiotensin II (Ang II) induces cardiac inflammation and oxidative stress, which also is implicated in the pathophysiology of adverse collagen accumulation-induced remodeling. Kaempferol (KPF), a kind of flavonoid compounds, is capable of anti-inflammatory and antioxidant activities. However, the target of KPF still remains blurred. In this study, we investigated the effect of KPF on Ang II-induced collagen accumulation and explored the underlying mechanisms. Our results suggested that KPF prevented Ang II-induced cardiac fibrosis and dysfunction, in mice challenged with subcutaneous injection of Ang II. In culture cells, KPF significantly reduced Ang II-induced collagen accumulation. Furthermore, KPF remarkably decreased inflammation and oxidative stress in Ang II-stimulated cardiac fibroblasts by modulating NF-κB/mitogen-activated protein kinase and AMPK/Nrf2 pathways. SN - 1533-4023 UR - https://www.unboundmedicine.com/medline/citation/31356553/Kaempferol_Prevents_Against_Ang_II_induced_Cardiac_Remodeling_Through_Attenuating_Ang_II_induced_Inflammation_and_Oxidative_Stress_ L2 - https://doi.org/10.1097/FJC.0000000000000713 DB - PRIME DP - Unbound Medicine ER -