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Asenapine maleate normalizes low frequency oscillatory deficits in a neurodevelopmental model of schizophrenia.
Neurosci Lett. 2019 10 15; 711:134404.NL

Abstract

Asenapine maleate (AM) is an atypical antipsychotic that, unlike many other antipsychotics, shows some efficacy in treating cognitive dysfunction in schizophrenia. Normal cognitive function has long since been associated with high frequency neuronal oscillations. However, recent research has highlighted the potential importance of low frequency oscillations. Here, the impact of AM on low frequency neural oscillatory activity was evaluated in the methylazoxymethanol acetate (MAM) rat model system used for the study schizophrenia, and the oscillatory signatures compared to those of haloperidol (HAL) and clozapine (CLZ). AM and CLZ normalized low frequency spectral power deficits in the prefrontal cortex, while HAL and AM reversed corticostriatal and corticocortical delta coherence deficits. However, only chronic AM administration normalized corticostriatal and corticocortical delta coherence deficits between 3-4 Hz. These findings support the idea that antipsychotic-induced amelioration of both delta coherence and power may be important for therapeutic efficacy in treating the cognitive deficits inherent in schizophrenia.

Authors+Show Affiliations

Department of Molecular and Cellular Biology, University of Guelph, Guelph, N1G 2W1 Ontario, Canada. Electronic address: mfoutene@uoguelph.ca.Department of Molecular and Cellular Biology, University of Guelph, Guelph, N1G 2W1 Ontario, Canada. Electronic address: jmanduca@uoguelph.ca.Department of Molecular and Cellular Biology, University of Guelph, Guelph, N1G 2W1 Ontario, Canada. Electronic address: pzoneve@uoguelph.ca.Department of Molecular and Cellular Biology, University of Guelph, Guelph, N1G 2W1 Ontario, Canada. Electronic address: perreaum@uoguelph.ca.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31356843

Citation

Foute Nelong, Tapia, et al. "Asenapine Maleate Normalizes Low Frequency Oscillatory Deficits in a Neurodevelopmental Model of Schizophrenia." Neuroscience Letters, vol. 711, 2019, p. 134404.
Foute Nelong T, Manduca JD, Zonneveld PM, et al. Asenapine maleate normalizes low frequency oscillatory deficits in a neurodevelopmental model of schizophrenia. Neurosci Lett. 2019;711:134404.
Foute Nelong, T., Manduca, J. D., Zonneveld, P. M., & Perreault, M. L. (2019). Asenapine maleate normalizes low frequency oscillatory deficits in a neurodevelopmental model of schizophrenia. Neuroscience Letters, 711, 134404. https://doi.org/10.1016/j.neulet.2019.134404
Foute Nelong T, et al. Asenapine Maleate Normalizes Low Frequency Oscillatory Deficits in a Neurodevelopmental Model of Schizophrenia. Neurosci Lett. 2019 10 15;711:134404. PubMed PMID: 31356843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asenapine maleate normalizes low frequency oscillatory deficits in a neurodevelopmental model of schizophrenia. AU - Foute Nelong,Tapia, AU - Manduca,Joshua D, AU - Zonneveld,Paula M, AU - Perreault,Melissa L, Y1 - 2019/07/26/ PY - 2019/06/10/received PY - 2019/07/25/accepted PY - 2019/7/30/pubmed PY - 2019/7/30/medline PY - 2019/7/30/entrez KW - Asenapine maleate KW - Clozapine KW - Cognition KW - Haloperidol KW - Neural oscillations KW - Schizophrenia SP - 134404 EP - 134404 JF - Neuroscience letters JO - Neurosci. Lett. VL - 711 N2 - Asenapine maleate (AM) is an atypical antipsychotic that, unlike many other antipsychotics, shows some efficacy in treating cognitive dysfunction in schizophrenia. Normal cognitive function has long since been associated with high frequency neuronal oscillations. However, recent research has highlighted the potential importance of low frequency oscillations. Here, the impact of AM on low frequency neural oscillatory activity was evaluated in the methylazoxymethanol acetate (MAM) rat model system used for the study schizophrenia, and the oscillatory signatures compared to those of haloperidol (HAL) and clozapine (CLZ). AM and CLZ normalized low frequency spectral power deficits in the prefrontal cortex, while HAL and AM reversed corticostriatal and corticocortical delta coherence deficits. However, only chronic AM administration normalized corticostriatal and corticocortical delta coherence deficits between 3-4 Hz. These findings support the idea that antipsychotic-induced amelioration of both delta coherence and power may be important for therapeutic efficacy in treating the cognitive deficits inherent in schizophrenia. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/31356843/Asenapine_maleate_normalizes_low_frequency_oscillatory_deficits_in_a_neurodevelopmental_model_of_schizophrenia L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(19)30507-5 DB - PRIME DP - Unbound Medicine ER -
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