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Nonalcoholic fatty liver disease increases risk of incident advanced chronic kidney disease: a propensity-matched cohort study.
J Intern Med. 2019 Dec; 286(6):711-722.JI

Abstract

BACKGROUND

As the prevalence of nonalcoholic fatty liver disease (NAFLD) escalates, understanding its potential impact on the development of chronic kidney disease (CKD) is needed.

OBJECTIVE

To determine the longitudinal association of NAFLD with the development of advanced CKD in the United States.

METHODS

A retrospective cohort analysis of the Truven Health MarketScan Database (2006-2015) was conducted. We used Cox proportional hazards models to compare the risk of developing CKD stages 3-5 in patients with NAFLD versus non-NAFLD, identified by ICD-9 codes, after 1:3 propensity score (PS) matching.

RESULTS

In a cohort of 262 619 newly diagnosed patients with NAFLD and 769 878 PS (1:3)-matched non-NAFLD patients, we identified 5766 and 8655 new advanced (stage 3-5) CKD cases, respectively. The crude CKD incidence rate was 8.2 and 5.5 per 1000 person-years in NAFLD and non-NAFLD groups, respectively. In multivariable Cox model, patients with NAFLD had a 41% increased risk of developing advanced CKD compared with non-NAFLD patients [adjusted hazard ratio (aHR), 1.41; 95% confidence interval (CI), 1.36-1.46]. In the sensitivity analysis adjusting for time-varying covariates after NAFLD diagnosis, NAFLD persisted as a significant CKD risk factor (aHR, 1.58; 95% CI, 1.52-1.66) and the association remained significant when stratified by age, gender and pre-existing comorbidities. The risk of CKD increased in NAFLD with compensated cirrhosis (aHR, 1.47; 95% CI, 1.36-1.59) and decompensated cirrhosis (aHR, 2.28; 95% CI, 2.12-2.46).

CONCLUSION

Nonalcoholic fatty liver disease was independently associated with an increased risk of advanced CKD development suggesting renal function screening and regular monitoring are needed in this population.

Authors+Show Affiliations

From the, Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy, Gainesville, FL, USA.From the, Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy, Gainesville, FL, USA.From the, Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy, Gainesville, FL, USA.Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31359543

Citation

Park, Haesuk, et al. "Nonalcoholic Fatty Liver Disease Increases Risk of Incident Advanced Chronic Kidney Disease: a Propensity-matched Cohort Study." Journal of Internal Medicine, vol. 286, no. 6, 2019, pp. 711-722.
Park H, Dawwas GK, Liu X, et al. Nonalcoholic fatty liver disease increases risk of incident advanced chronic kidney disease: a propensity-matched cohort study. J Intern Med. 2019;286(6):711-722.
Park, H., Dawwas, G. K., Liu, X., & Nguyen, M. H. (2019). Nonalcoholic fatty liver disease increases risk of incident advanced chronic kidney disease: a propensity-matched cohort study. Journal of Internal Medicine, 286(6), 711-722. https://doi.org/10.1111/joim.12964
Park H, et al. Nonalcoholic Fatty Liver Disease Increases Risk of Incident Advanced Chronic Kidney Disease: a Propensity-matched Cohort Study. J Intern Med. 2019;286(6):711-722. PubMed PMID: 31359543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic fatty liver disease increases risk of incident advanced chronic kidney disease: a propensity-matched cohort study. AU - Park,Haesuk, AU - Dawwas,Ghadeer K, AU - Liu,Xinyue, AU - Nguyen,Mindie H, Y1 - 2019/08/23/ PY - 2019/7/31/pubmed PY - 2020/5/26/medline PY - 2019/7/31/entrez KW - chronic kidney disease KW - cirrhosis KW - cohort KW - nonalcoholic fatty liver disease SP - 711 EP - 722 JF - Journal of internal medicine JO - J Intern Med VL - 286 IS - 6 N2 - BACKGROUND: As the prevalence of nonalcoholic fatty liver disease (NAFLD) escalates, understanding its potential impact on the development of chronic kidney disease (CKD) is needed. OBJECTIVE: To determine the longitudinal association of NAFLD with the development of advanced CKD in the United States. METHODS: A retrospective cohort analysis of the Truven Health MarketScan Database (2006-2015) was conducted. We used Cox proportional hazards models to compare the risk of developing CKD stages 3-5 in patients with NAFLD versus non-NAFLD, identified by ICD-9 codes, after 1:3 propensity score (PS) matching. RESULTS: In a cohort of 262 619 newly diagnosed patients with NAFLD and 769 878 PS (1:3)-matched non-NAFLD patients, we identified 5766 and 8655 new advanced (stage 3-5) CKD cases, respectively. The crude CKD incidence rate was 8.2 and 5.5 per 1000 person-years in NAFLD and non-NAFLD groups, respectively. In multivariable Cox model, patients with NAFLD had a 41% increased risk of developing advanced CKD compared with non-NAFLD patients [adjusted hazard ratio (aHR), 1.41; 95% confidence interval (CI), 1.36-1.46]. In the sensitivity analysis adjusting for time-varying covariates after NAFLD diagnosis, NAFLD persisted as a significant CKD risk factor (aHR, 1.58; 95% CI, 1.52-1.66) and the association remained significant when stratified by age, gender and pre-existing comorbidities. The risk of CKD increased in NAFLD with compensated cirrhosis (aHR, 1.47; 95% CI, 1.36-1.59) and decompensated cirrhosis (aHR, 2.28; 95% CI, 2.12-2.46). CONCLUSION: Nonalcoholic fatty liver disease was independently associated with an increased risk of advanced CKD development suggesting renal function screening and regular monitoring are needed in this population. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/31359543/Nonalcoholic_fatty_liver_disease_increases_risk_of_incident_advanced_chronic_kidney_disease:_a_propensity_matched_cohort_study_ DB - PRIME DP - Unbound Medicine ER -