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[Preparation and quality standard of standard decoction of Scrophulariae Radix pieces].
Zhongguo Zhong Yao Za Zhi. 2019 Jun; 44(12):2493-2498.ZZ

Abstract

The standard decoction of Chinese herbal decoction pieces is a standard reference substance to measure whether different dosage forms of Chinese medicine are basically consistent with those of clinical decoction,and provides new ideas and methods for effectively solving the problems of uneven quality in Chinese medicine dispensing granules. In this study,a systematic method for evaluating the quality of Scrophulariae Radix decoction was established from the perspective of " standard decoction",providing reference for the quality control of the Scrophulariae Radix dispensing granules. 15 batches of Scrophulariae Radix decoction pieces from different origins were collected,and 15 batches of standard decoctions were prepared according to the standardized process with water as solvent.Harpagide and harpagoside were used as quantitative detection indicators to determine the content,calculate the transfer rates and determine the extraction rate. The high performance liquid chromatography(HPLC) was used to establish a standard decoction fingerprint analysis method. The results showed that the transfer rates of harpagide and harpagoside in 15 batches of Scrophulariae Radix pieces standard decoction were(70. 84±13. 39) % and(48. 56±6. 40) % respectively; the extraction rate was(57. 47±5. 89) %. Nine peaks were identified in the HPLC fingerprint,and the similarity was higher than 0. 97 between the fingerprints of 15 batches of standard decoction and the control fingerprint. In this study,the preparation process of standard decoction of Scrophulariae Radix pieces conformed to the traditional decoction preparation method. The sources of the samples were representative,and the established fingerprint method was stable and feasible,which can provide reference for the preparation and quality control of Scrophulariae Radix dispensing granules.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Shaanxi University of Chinese Medicine Xianyang 712083,China.

Ankang Beijing Medical University Pharmaceutical Co.,Ltd. Ankang 725000,China.

Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Shaanxi University of Chinese Medicine Xianyang 712083,China.

Xi'an Traditional Chinese Medicine Hospital Xi'an 710021,China.

Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Shaanxi University of Chinese Medicine Xianyang 712083,China.

Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Shaanxi University of Chinese Medicine Xianyang 712083,China.

Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Shaanxi University of Chinese Medicine Xianyang 712083,China.

Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Shaanxi University of Chinese Medicine Xianyang 712083,China.

Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Shaanxi University of Chinese Medicine Xianyang 712083,China.

Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Shaanxi University of Chinese Medicine Xianyang 712083,China.

MeSH

Chromatography, High Pressure LiquidDrugs, Chinese HerbalPlant RootsQuality ControlScrophularia

Pub Type(s)

Journal Article

Language

chi

PubMed ID

31359716

Citation

Xu, Hong-Bo, et al. "[Preparation and Quality Standard of Standard Decoction of Scrophulariae Radix Pieces]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 44, no. 12, 2019, pp. 2493-2498.

Xu HB, Gao CH, Cai XH, et al. [Preparation and quality standard of standard decoction of Scrophulariae Radix pieces]. Zhongguo Zhong Yao Za Zhi. 2019;44(12):2493-2498.

Xu, H. B., Gao, C. H., Cai, X. H., Yang, K., Zhang, Y., Wang, J. J., Xu, H. L., Zhang, L., Chen, S. Y., & Tang, Z. S. (2019). [Preparation and quality standard of standard decoction of Scrophulariae Radix pieces]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 44(12), 2493-2498. https://doi.org/10.19540/j.cnki.cjcmm.20190221.003

Xu HB, et al. [Preparation and Quality Standard of Standard Decoction of Scrophulariae Radix Pieces]. Zhongguo Zhong Yao Za Zhi. 2019;44(12):2493-2498. PubMed PMID: 31359716.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - [Preparation and quality standard of standard decoction of Scrophulariae Radix pieces]. AU - Xu,Hong-Bo, AU - Gao,Chun-Hui, AU - Cai,Xing-Hang, AU - Yang,Kang, AU - Zhang,Yu, AU - Wang,Juan-Juan, AU - Xu,Huai-Li, AU - Zhang,Lu, AU - Chen,Su-Yun, AU - Tang,Zhi-Shu, PY - 2019/7/31/entrez PY - 2019/7/31/pubmed PY - 2019/9/24/medline KW - Scrophularia ningpoensis KW - fingerprint KW - quality standard KW - standard decoction SP - 2493 EP - 2498 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 44 IS - 12 N2 - The standard decoction of Chinese herbal decoction pieces is a standard reference substance to measure whether different dosage forms of Chinese medicine are basically consistent with those of clinical decoction,and provides new ideas and methods for effectively solving the problems of uneven quality in Chinese medicine dispensing granules. In this study,a systematic method for evaluating the quality of Scrophulariae Radix decoction was established from the perspective of " standard decoction",providing reference for the quality control of the Scrophulariae Radix dispensing granules. 15 batches of Scrophulariae Radix decoction pieces from different origins were collected,and 15 batches of standard decoctions were prepared according to the standardized process with water as solvent.Harpagide and harpagoside were used as quantitative detection indicators to determine the content,calculate the transfer rates and determine the extraction rate. The high performance liquid chromatography(HPLC) was used to establish a standard decoction fingerprint analysis method. The results showed that the transfer rates of harpagide and harpagoside in 15 batches of Scrophulariae Radix pieces standard decoction were(70. 84±13. 39) % and(48. 56±6. 40) % respectively; the extraction rate was(57. 47±5. 89) %. Nine peaks were identified in the HPLC fingerprint,and the similarity was higher than 0. 97 between the fingerprints of 15 batches of standard decoction and the control fingerprint. In this study,the preparation process of standard decoction of Scrophulariae Radix pieces conformed to the traditional decoction preparation method. The sources of the samples were representative,and the established fingerprint method was stable and feasible,which can provide reference for the preparation and quality control of Scrophulariae Radix dispensing granules. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/31359716/[Preparation_and_quality_standard_of_standard_decoction_of_Scrophulariae_Radix_pieces]_ DB - PRIME DP - Unbound Medicine ER -