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Safety of sugammadex for reversal of neuromuscular block.
Expert Opin Drug Saf 2019; 18(10):883-891EO

Abstract

Introduction: Sugammadex is a modified cyclodextrin that is able to reverse neuromuscular block induced by aminosteroidal neuromuscular blocking drugs. Compared to reversal with neostigmine, it reverses neuromuscular block quicker and more predictable and without cholinergic side effects. However, there have been concerns about sugammadex ability to bind other drugs and its effects on QT interval and clotting times. In addition, sugammadex might induce hypersensitivity reactions more frequently than initially anticipated. This review summarizes current evidence with regard to these and other safety aspects of sugammadex. Areas covered: This review provides an overview of the efficacy of sugammadex in various patient populations, evaluates potential interactions with other drugs and discusses adverse effects and reactions that have been reported in the literature. Expert opinion: Sugammadex quickly reverses aminosteroid neuromuscular block with less side effects compared to neostigmine. As such, it has the potential to significantly reduce the incidence of residual neuromuscular block and to improve postoperative pulmonary outcome. Current safety concerns mainly focus on hypersensitivity reactions and cardiac arrhythmias. Although the absolute risk for these events is low, ongoing vigilance and research in this area are needed.

Authors+Show Affiliations

Department of Anesthesiology, Leiden University Medical Center , Leiden , The Netherlands.Department of Anesthesiology, Leiden University Medical Center , Leiden , The Netherlands.Livingston , UK.Department of Anesthesiology, Leiden University Medical Center , Leiden , The Netherlands.Department of Anesthesiology, Leiden University Medical Center , Leiden , The Netherlands.Department of Anesthesiology, Leiden University Medical Center , Leiden , The Netherlands.Department of Anesthesiology, Leiden University Medical Center , Leiden , The Netherlands.Department of Anesthesiology, Leiden University Medical Center , Leiden , The Netherlands.

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

31359807

Citation

Honing, Ghm, et al. "Safety of Sugammadex for Reversal of Neuromuscular Block." Expert Opinion On Drug Safety, vol. 18, no. 10, 2019, pp. 883-891.
Honing G, Martini CH, Bom A, et al. Safety of sugammadex for reversal of neuromuscular block. Expert Opin Drug Saf. 2019;18(10):883-891.
Honing, G., Martini, C. H., Bom, A., van Velzen, M., Niesters, M., Aarts, L., ... Boon, M. (2019). Safety of sugammadex for reversal of neuromuscular block. Expert Opinion On Drug Safety, 18(10), pp. 883-891. doi:10.1080/14740338.2019.1649393.
Honing G, et al. Safety of Sugammadex for Reversal of Neuromuscular Block. Expert Opin Drug Saf. 2019;18(10):883-891. PubMed PMID: 31359807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety of sugammadex for reversal of neuromuscular block. AU - Honing,Ghm, AU - Martini,C H, AU - Bom,A, AU - van Velzen,M, AU - Niesters,M, AU - Aarts,Lphj, AU - Dahan,A, AU - Boon,M, Y1 - 2019/08/07/ PY - 2019/7/31/pubmed PY - 2019/10/12/medline PY - 2019/7/31/entrez KW - Expert opinion KW - neuromuscular blockade reversal KW - rocuronium safety evaluation KW - sugammadex SP - 883 EP - 891 JF - Expert opinion on drug safety JO - Expert Opin Drug Saf VL - 18 IS - 10 N2 - Introduction: Sugammadex is a modified cyclodextrin that is able to reverse neuromuscular block induced by aminosteroidal neuromuscular blocking drugs. Compared to reversal with neostigmine, it reverses neuromuscular block quicker and more predictable and without cholinergic side effects. However, there have been concerns about sugammadex ability to bind other drugs and its effects on QT interval and clotting times. In addition, sugammadex might induce hypersensitivity reactions more frequently than initially anticipated. This review summarizes current evidence with regard to these and other safety aspects of sugammadex. Areas covered: This review provides an overview of the efficacy of sugammadex in various patient populations, evaluates potential interactions with other drugs and discusses adverse effects and reactions that have been reported in the literature. Expert opinion: Sugammadex quickly reverses aminosteroid neuromuscular block with less side effects compared to neostigmine. As such, it has the potential to significantly reduce the incidence of residual neuromuscular block and to improve postoperative pulmonary outcome. Current safety concerns mainly focus on hypersensitivity reactions and cardiac arrhythmias. Although the absolute risk for these events is low, ongoing vigilance and research in this area are needed. SN - 1744-764X UR - https://www.unboundmedicine.com/medline/citation/31359807/Safety_of_sugammadex_for_reversal_of_neuromuscular_block L2 - http://www.tandfonline.com/doi/full/10.1080/14740338.2019.1649393 DB - PRIME DP - Unbound Medicine ER -