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Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea.
Can J Infect Dis Med Microbiol 2019; 2019:9351801CJ

Abstract

Background/

Aim.

In Korea, the rate of Helicobacter pylori (H. pylori) eradication has declined steadily as a result of increasing resistance to antibiotics, especially dual resistance to clarithromycin and metronidazole. However, microbiological culture data on drug-resistant H. pylori is lacking. This study evaluated the antimicrobial efficacy of candidate antibiotics against resistant H. pylori strains. Methods. After retrospectively reviewing the data from the Helicobacter Registry in Gil Medical Center (GMC) and Asan Medical Center (AMC), along with 4 reference strains, we selected the 31 single- or multidrug-resistant strains. The susceptibility of the H. pylori strains to seven antibiotics (clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline, rifabutin, and furazolidone) and minimum inhibitory concentration were tested using the broth microdilution technique.

Results.

Among 31 antibiotic resistance strains for H. pylori, there were no strains resistant to rifabutin or furazolidone, which had MICs of <0.008 and 0.5 μg/mL, respectively. Only one tetracycline-resistant strain was found (MIC < 2 μg/mL). Amoxicillin and levofloxacin were relatively less effective against the H. pylori strains compared to rifabutin or furazolidone (resistance rates 22.6%, 1.9%, respectively). Tetracycline showed the relatively low resistance rates (3.2%) for H. pylori strains.

Conclusions.

Therefore, along with tetracycline which has already been used as a component for second-line eradication regimen for Helicobacter, rifabutin and furazolidone, alone or in combination, could be used to eradicate antibiotic-resistant H. pylori strains where drug-resistant Helicobacter spp. are increasing.

Authors+Show Affiliations

Department of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of Korea.Department of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of Korea.Department of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of Korea.Department of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of Korea.Department of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of Korea.Department of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of Korea.Department of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of Korea.Department of Gastroenterology, Asan Medical Center, Ulsan University, Seoul, Republic of Korea.Department of Gastroenterology, Asan Medical Center, Ulsan University, Seoul, Republic of Korea.Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31360270

Citation

Choi, Youn I., et al. "Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. Pylori in Korea." The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Medicale, vol. 2019, 2019, p. 9351801.
Choi YI, Jeong SH, Chung JW, et al. Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea. Can J Infect Dis Med Microbiol. 2019;2019:9351801.
Choi, Y. I., Jeong, S. H., Chung, J. W., Park, D. K., Kim, K. O., Kwon, K. A., ... Lee, S. M. (2019). Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea. The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Medicale, 2019, p. 9351801. doi:10.1155/2019/9351801.
Choi YI, et al. Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. Pylori in Korea. Can J Infect Dis Med Microbiol. 2019;2019:9351801. PubMed PMID: 31360270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea. AU - Choi,Youn I, AU - Jeong,Sang-Ho, AU - Chung,Jun-Won, AU - Park,Dong Kyun, AU - Kim,Kyoung Oh, AU - Kwon,Kwang An, AU - Kim,Yoon Jae, AU - So,Seol, AU - Lee,Jeong Hoon, AU - Jeong,Jin-Young, AU - Lee,Sun-Mi, Y1 - 2019/07/10/ PY - 2019/04/01/received PY - 2019/06/20/revised PY - 2019/06/24/accepted PY - 2019/7/31/entrez PY - 2019/7/31/pubmed PY - 2019/7/31/medline SP - 9351801 EP - 9351801 JF - The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale JO - Can J Infect Dis Med Microbiol VL - 2019 N2 - Background/Aim. In Korea, the rate of Helicobacter pylori (H. pylori) eradication has declined steadily as a result of increasing resistance to antibiotics, especially dual resistance to clarithromycin and metronidazole. However, microbiological culture data on drug-resistant H. pylori is lacking. This study evaluated the antimicrobial efficacy of candidate antibiotics against resistant H. pylori strains. Methods. After retrospectively reviewing the data from the Helicobacter Registry in Gil Medical Center (GMC) and Asan Medical Center (AMC), along with 4 reference strains, we selected the 31 single- or multidrug-resistant strains. The susceptibility of the H. pylori strains to seven antibiotics (clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline, rifabutin, and furazolidone) and minimum inhibitory concentration were tested using the broth microdilution technique. Results. Among 31 antibiotic resistance strains for H. pylori, there were no strains resistant to rifabutin or furazolidone, which had MICs of <0.008 and 0.5 μg/mL, respectively. Only one tetracycline-resistant strain was found (MIC < 2 μg/mL). Amoxicillin and levofloxacin were relatively less effective against the H. pylori strains compared to rifabutin or furazolidone (resistance rates 22.6%, 1.9%, respectively). Tetracycline showed the relatively low resistance rates (3.2%) for H. pylori strains. Conclusions. Therefore, along with tetracycline which has already been used as a component for second-line eradication regimen for Helicobacter, rifabutin and furazolidone, alone or in combination, could be used to eradicate antibiotic-resistant H. pylori strains where drug-resistant Helicobacter spp. are increasing. SN - 1712-9532 UR - https://www.unboundmedicine.com/medline/citation/31360270/Rifabutin_and_Furazolidone_Could_Be_the_Candidates_of_the_Rescue_Regimen_for_Antibiotic-Resistant_H._pylori_in_Korea L2 - https://dx.doi.org/10.1155/2019/9351801 DB - PRIME DP - Unbound Medicine ER -