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Immunomodulation as a Neuroprotective Strategy for Glaucoma Treatment.
Curr Ophthalmol Rep. 2019 Jun; 7(2):160-169.CO

Abstract

PURPOSE OF REVIEW

This review aims to highlight the current knowledge about inflammatory mechanisms of neurodegeneration in glaucoma with emphasis on potential immunomodulation strategies.

RECENT FINDINGS

Glaucomatous retina and optic nerve present multiple evidences of inflammatory responses of astroglia, microglia, and blood-born immune cells. Although adaptive/protective responses of resident or systemic immune cells can support neurons and promote tissue repair mechanisms after injurious insults, prolonged inflammatory processes can also produce neurotoxic mediators. Treatments targeting these neurodestructive outcomes may restore immune homeostasis and protect neurons from inflammatory injury. Due to widespread and chronic nature of neuroinflammation in glaucoma, immunomodulation offers a treatment strategy to protect different neuronal compartments of RGCs during the chronic and asynchronous course of neurodegeneration. Uncovering of distinct molecular responses and interactions of different immune cells that determine the neuroinflammatory phenotype and participate in neurodegenerative outcomes will be critical to develop effective strategies for immunomodulation in glaucoma.

SUMMARY

Neuroinflammation has increasingly been recognized to play an important role in glaucomatous neurodegeneration, and its modulation appears to be a promising treatment strategy for neuroprotection.

Authors+Show Affiliations

Columbia University, College of Physicians and Surgeons, Department of Ophthalmology, New York, NY.Columbia University, College of Physicians and Surgeons, Department of Ophthalmology, New York, NY.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31360618

Citation

Bariş, Mine, and Gülgün Tezel. "Immunomodulation as a Neuroprotective Strategy for Glaucoma Treatment." Current Ophthalmology Reports, vol. 7, no. 2, 2019, pp. 160-169.
Bariş M, Tezel G. Immunomodulation as a Neuroprotective Strategy for Glaucoma Treatment. Curr Ophthalmol Rep. 2019;7(2):160-169.
Bariş, M., & Tezel, G. (2019). Immunomodulation as a Neuroprotective Strategy for Glaucoma Treatment. Current Ophthalmology Reports, 7(2), 160-169.
Bariş M, Tezel G. Immunomodulation as a Neuroprotective Strategy for Glaucoma Treatment. Curr Ophthalmol Rep. 2019;7(2):160-169. PubMed PMID: 31360618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulation as a Neuroprotective Strategy for Glaucoma Treatment. AU - Bariş,Mine, AU - Tezel,Gülgün, Y1 - 2019/04/23/ PY - 2019/7/31/entrez PY - 2019/7/31/pubmed PY - 2019/7/31/medline KW - Glaucoma KW - immunomodulation KW - immunoregulation KW - neurodegeneration KW - neuroinflammation KW - neuroprotection SP - 160 EP - 169 JF - Current ophthalmology reports JO - Curr Ophthalmol Rep VL - 7 IS - 2 N2 - PURPOSE OF REVIEW: This review aims to highlight the current knowledge about inflammatory mechanisms of neurodegeneration in glaucoma with emphasis on potential immunomodulation strategies. RECENT FINDINGS: Glaucomatous retina and optic nerve present multiple evidences of inflammatory responses of astroglia, microglia, and blood-born immune cells. Although adaptive/protective responses of resident or systemic immune cells can support neurons and promote tissue repair mechanisms after injurious insults, prolonged inflammatory processes can also produce neurotoxic mediators. Treatments targeting these neurodestructive outcomes may restore immune homeostasis and protect neurons from inflammatory injury. Due to widespread and chronic nature of neuroinflammation in glaucoma, immunomodulation offers a treatment strategy to protect different neuronal compartments of RGCs during the chronic and asynchronous course of neurodegeneration. Uncovering of distinct molecular responses and interactions of different immune cells that determine the neuroinflammatory phenotype and participate in neurodegenerative outcomes will be critical to develop effective strategies for immunomodulation in glaucoma. SUMMARY: Neuroinflammation has increasingly been recognized to play an important role in glaucomatous neurodegeneration, and its modulation appears to be a promising treatment strategy for neuroprotection. SN - 2167-4868 UR - https://www.unboundmedicine.com/medline/citation/31360618/Immunomodulation_as_a_Neuroprotective_Strategy_for_Glaucoma_Treatment_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31360618/ DB - PRIME DP - Unbound Medicine ER -
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