Tags

Type your tag names separated by a space and hit enter

Linear Peptides Containing d-Leucine with Neuroprotective Activities from the Leech Whitmania pigra Whitman.
J Nat Prod 2019; 82(8):2349-2353JN

Abstract

Three new linear peptides containing d-leucine, named whitmantides A-C (1-3), were isolated from the dried whole bodies of Whitmania pigra Whitman. Their structures with absolute configurations were elucidated by Edman degradation, mass spectrometry, Marfey's analysis, and solid-phase synthesis. It is the first time that peptides containing d-amino acid in leeches were discovered. Compounds 1-3 displayed neuroprotective activities against oxygen-glucose deprivation/reperfusion injury on Neuro-2a cells. In addition, ex vivo serum stability tests showed that 1-3 were resistant to protease degradation.

Authors+Show Affiliations

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , People's Republic of China. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , People's Republic of China.Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , People's Republic of China. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , People's Republic of China.Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , People's Republic of China. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , People's Republic of China.Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , People's Republic of China. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , People's Republic of China.Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , People's Republic of China. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , People's Republic of China.Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , People's Republic of China. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31361480

Citation

Zhang, Zi-Yue, et al. "Linear Peptides Containing d-Leucine With Neuroprotective Activities From the Leech Whitmania Pigra Whitman." Journal of Natural Products, vol. 82, no. 8, 2019, pp. 2349-2353.
Zhang ZY, Ma N, Tao LJ, et al. Linear Peptides Containing d-Leucine with Neuroprotective Activities from the Leech Whitmania pigra Whitman. J Nat Prod. 2019;82(8):2349-2353.
Zhang, Z. Y., Ma, N., Tao, L. J., Gong, X. Y., Ye, W. C., & Wang, L. (2019). Linear Peptides Containing d-Leucine with Neuroprotective Activities from the Leech Whitmania pigra Whitman. Journal of Natural Products, 82(8), pp. 2349-2353. doi:10.1021/acs.jnatprod.9b00322.
Zhang ZY, et al. Linear Peptides Containing d-Leucine With Neuroprotective Activities From the Leech Whitmania Pigra Whitman. J Nat Prod. 2019 Aug 23;82(8):2349-2353. PubMed PMID: 31361480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linear Peptides Containing d-Leucine with Neuroprotective Activities from the Leech Whitmania pigra Whitman. AU - Zhang,Zi-Yue, AU - Ma,Nan, AU - Tao,Li-Jun, AU - Gong,Xue-Ying, AU - Ye,Wen-Cai, AU - Wang,Lei, Y1 - 2019/07/30/ PY - 2019/7/31/pubmed PY - 2019/7/31/medline PY - 2019/7/31/entrez SP - 2349 EP - 2353 JF - Journal of natural products JO - J. Nat. Prod. VL - 82 IS - 8 N2 - Three new linear peptides containing d-leucine, named whitmantides A-C (1-3), were isolated from the dried whole bodies of Whitmania pigra Whitman. Their structures with absolute configurations were elucidated by Edman degradation, mass spectrometry, Marfey's analysis, and solid-phase synthesis. It is the first time that peptides containing d-amino acid in leeches were discovered. Compounds 1-3 displayed neuroprotective activities against oxygen-glucose deprivation/reperfusion injury on Neuro-2a cells. In addition, ex vivo serum stability tests showed that 1-3 were resistant to protease degradation. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/31361480/Linear_Peptides_Containing_d-Leucine_with_Neuroprotective_Activities_from_the_Leech_Whitmania_pigra_Whitman L2 - https://dx.doi.org/10.1021/acs.jnatprod.9b00322 DB - PRIME DP - Unbound Medicine ER -