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Resection margins and local recurrences of impalpable breast cancer: Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL).
Breast 2019; 47:93-101B

Abstract

OBJECTIVES

The aim of this retrospective study is to compare surgical margins, reoperation rates and local recurrences after breast conserving surgery (BCS) using radioguided occult lesion localization (ROLL) or radioactive seed localization (RSL).

MATERIALS AND METHODS

We reviewed 744 consecutive patients with impalpable primary invasive breast cancer who underwent BCS at Helsinki University Hospital between 2010 and 2012. ROLL was used in our unit until October 31st, 2011; from November 1st we changed localization method to RSL.

RESULTS

318 patients underwent ROLL and 426 RSL. Patients in the RSL group had more often multifocal (p = 0.013) tumours. No statistically significant differences were found regarding tumour size, specimen weight, histology or grade of tumours or lymph node status. 42 (5.6%) patients were reoperated because of insufficient margins, 13 (4.1%) in the ROLL group and 29 (6.8%) in the RSL group. The reoperation rate was not different between the groups either in the univariable analysis (p = 0.112) or in the multivariable binary logistic regression analysis (p = 0.204). Risk factors for reoperations were multifocality of the tumour (p < 0.001), extensive intraductal component (p < 0.001), larger tumour size (p = 0.011), and smaller specimen weight (p = 0.014). The median follow-up time in the ROLL group was 81 (8-94) months and 64 (3-73) months in the RSL group. The five-year local recurrence-free survival (LRFS) estimates for ROLL and RSL groups were 98.0% and 99.4%, respectively (log-rank test, p = 0.323).

CONCLUSION

Reoperation rates and LRFS were comparable for ROLL and RSL in patients with impalpable breast cancer treated with BCS.

Authors+Show Affiliations

Breast Surgery Unit, Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital Finland, P.O. Box 263, 00029, HUS, Finland. Electronic address: laura.niinikoski@hus.fi.HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029, HUS, Finland.Breast Surgery Unit, Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital Finland, P.O. Box 263, 00029, HUS, Finland.Breast Surgery Unit, Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital Finland, P.O. Box 263, 00029, HUS, Finland.Breast Surgery Unit, Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital Finland, P.O. Box 263, 00029, HUS, Finland.Department of Pathology, University of Helsinki, Helsinki University Hospital Finland, P.O. Box 400, 00029, HUS, Finland.Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital Finland, PO Box 180, 00029, HUS, Finland.Breast Surgery Unit, Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital Finland, P.O. Box 263, 00029, HUS, Finland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31362135

Citation

Niinikoski, Laura, et al. "Resection Margins and Local Recurrences of Impalpable Breast Cancer: Comparison Between Radioguided Occult Lesion Localization (ROLL) and Radioactive Seed Localization (RSL)." Breast (Edinburgh, Scotland), vol. 47, 2019, pp. 93-101.
Niinikoski L, Hukkinen K, Leidenius MHK, et al. Resection margins and local recurrences of impalpable breast cancer: Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL). Breast. 2019;47:93-101.
Niinikoski, L., Hukkinen, K., Leidenius, M. H. K., Vaara, P., Voynov, A., Heikkilä, P., ... Meretoja, T. J. (2019). Resection margins and local recurrences of impalpable breast cancer: Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL). Breast (Edinburgh, Scotland), 47, pp. 93-101. doi:10.1016/j.breast.2019.07.004.
Niinikoski L, et al. Resection Margins and Local Recurrences of Impalpable Breast Cancer: Comparison Between Radioguided Occult Lesion Localization (ROLL) and Radioactive Seed Localization (RSL). Breast. 2019;47:93-101. PubMed PMID: 31362135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resection margins and local recurrences of impalpable breast cancer: Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL). AU - Niinikoski,Laura, AU - Hukkinen,Katja, AU - Leidenius,Marjut H K, AU - Vaara,Päivi, AU - Voynov,Aleksandar, AU - Heikkilä,Päivi, AU - Mattson,Johanna, AU - Meretoja,Tuomo J, Y1 - 2019/07/23/ PY - 2019/05/23/received PY - 2019/06/28/revised PY - 2019/07/22/accepted PY - 2019/7/31/pubmed PY - 2019/7/31/medline PY - 2019/7/31/entrez KW - Breast cancer KW - Breast conserving surgery KW - Local recurrence KW - Radioactive seed localization KW - Radioguided occult lesion localization KW - Surgical margins SP - 93 EP - 101 JF - Breast (Edinburgh, Scotland) JO - Breast VL - 47 N2 - OBJECTIVES: The aim of this retrospective study is to compare surgical margins, reoperation rates and local recurrences after breast conserving surgery (BCS) using radioguided occult lesion localization (ROLL) or radioactive seed localization (RSL). MATERIALS AND METHODS: We reviewed 744 consecutive patients with impalpable primary invasive breast cancer who underwent BCS at Helsinki University Hospital between 2010 and 2012. ROLL was used in our unit until October 31st, 2011; from November 1st we changed localization method to RSL. RESULTS: 318 patients underwent ROLL and 426 RSL. Patients in the RSL group had more often multifocal (p = 0.013) tumours. No statistically significant differences were found regarding tumour size, specimen weight, histology or grade of tumours or lymph node status. 42 (5.6%) patients were reoperated because of insufficient margins, 13 (4.1%) in the ROLL group and 29 (6.8%) in the RSL group. The reoperation rate was not different between the groups either in the univariable analysis (p = 0.112) or in the multivariable binary logistic regression analysis (p = 0.204). Risk factors for reoperations were multifocality of the tumour (p < 0.001), extensive intraductal component (p < 0.001), larger tumour size (p = 0.011), and smaller specimen weight (p = 0.014). The median follow-up time in the ROLL group was 81 (8-94) months and 64 (3-73) months in the RSL group. The five-year local recurrence-free survival (LRFS) estimates for ROLL and RSL groups were 98.0% and 99.4%, respectively (log-rank test, p = 0.323). CONCLUSION: Reoperation rates and LRFS were comparable for ROLL and RSL in patients with impalpable breast cancer treated with BCS. SN - 1532-3080 UR - https://www.unboundmedicine.com/medline/citation/31362135/Resection_margins_and_local_recurrences_of_impalpable_breast_cancer:_Comparison_between_radioguided_occult_lesion_localization__ROLL__and_radioactive_seed_localization__RSL__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9776(19)30533-8 DB - PRIME DP - Unbound Medicine ER -