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Effect of equisetum arvense extract on bone mineral density in Wistar rats via digital radiography.
Caspian J Intern Med 2019; 10(2):176-182CJ

Abstract

Background

Osteoporosis is a common disease of old age. The present study used digital radiography to determine the effects of equisetum arvense extract on the bone mineral density (BMD) of experimental rats.

Methods

In this experimental study, 25 male and 25 female Wistar rats, aged three weeks old and weighing 100 grams, were randomly divided into five groups: (1) control group, (2) calcium/vitamin D group, (3) 60 mg/kg equisetum arvense extract group, (4) 90 mg/kg equisetum arvense extract group and (5) 120 mg/kg equisetum arvense extract group. Rats received these diets for 30 days. The spongy bone density was measured in the maxilla and mandible using digital radiography and the serum levels of calcium, vitamin D and phosphorus were measured at baseline and after 30 days. The data were analyzed using ANOVA and Tukey test.

Results

There was no significant difference between serum calcium and phosphorus levels in the five groups before and after 30 days. The serum vitamin D in the group receiving calcium and vitamin D was significantly higher than in the other groups (with average values of 24.7, 61.7, 23.47, 23.95 and 39.16 in the male groups 1 to 5 and 29.0, 85.07, 31.58, 42.34 and 18.83 in the female groups 1 to 5, respectively (p<0.001). Moreover, the increased mandibular BMD in the 120 mg/kg equisetum arvense group was significantly higher than in the control group (p<0.01).

Conclusion

A diet containing 120 mg/kg equisetum arvense extract resulted in increased mandibular bone mineral density.

Authors+Show Affiliations

Student Research Committee, Babol University of Medical Science, Babol, Iran.Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran.Student Research Committee, Babol University of Medical Science, Babol, Iran.Oral Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran.Oral Health Research Center, Health Research Institute, Babol University of Medical Science, Babol, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31363396

Citation

Arbabzadegan, Nazanin, et al. "Effect of Equisetum Arvense Extract On Bone Mineral Density in Wistar Rats Via Digital Radiography." Caspian Journal of Internal Medicine, vol. 10, no. 2, 2019, pp. 176-182.
Arbabzadegan N, Moghadamnia AA, Kazemi S, et al. Effect of equisetum arvense extract on bone mineral density in Wistar rats via digital radiography. Caspian J Intern Med. 2019;10(2):176-182.
Arbabzadegan, N., Moghadamnia, A. A., Kazemi, S., Nozari, F., Moudi, E., & Haghanifar, S. (2019). Effect of equisetum arvense extract on bone mineral density in Wistar rats via digital radiography. Caspian Journal of Internal Medicine, 10(2), pp. 176-182. doi:10.22088/cjim.10.2.176.
Arbabzadegan N, et al. Effect of Equisetum Arvense Extract On Bone Mineral Density in Wistar Rats Via Digital Radiography. Caspian J Intern Med. 2019;10(2):176-182. PubMed PMID: 31363396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of equisetum arvense extract on bone mineral density in Wistar rats via digital radiography. AU - Arbabzadegan,Nazanin, AU - Moghadamnia,Ali Akbar, AU - Kazemi,Sohrab, AU - Nozari,Farideh, AU - Moudi,Ehsan, AU - Haghanifar,Sina, PY - 2019/8/1/entrez PY - 2019/8/1/pubmed PY - 2019/8/1/medline KW - Bone mineral density KW - Digital radiography. KW - Equisetum arvense KW - Osteoporosis SP - 176 EP - 182 JF - Caspian journal of internal medicine JO - Caspian J Intern Med VL - 10 IS - 2 N2 - Background: Osteoporosis is a common disease of old age. The present study used digital radiography to determine the effects of equisetum arvense extract on the bone mineral density (BMD) of experimental rats. Methods: In this experimental study, 25 male and 25 female Wistar rats, aged three weeks old and weighing 100 grams, were randomly divided into five groups: (1) control group, (2) calcium/vitamin D group, (3) 60 mg/kg equisetum arvense extract group, (4) 90 mg/kg equisetum arvense extract group and (5) 120 mg/kg equisetum arvense extract group. Rats received these diets for 30 days. The spongy bone density was measured in the maxilla and mandible using digital radiography and the serum levels of calcium, vitamin D and phosphorus were measured at baseline and after 30 days. The data were analyzed using ANOVA and Tukey test. Results: There was no significant difference between serum calcium and phosphorus levels in the five groups before and after 30 days. The serum vitamin D in the group receiving calcium and vitamin D was significantly higher than in the other groups (with average values of 24.7, 61.7, 23.47, 23.95 and 39.16 in the male groups 1 to 5 and 29.0, 85.07, 31.58, 42.34 and 18.83 in the female groups 1 to 5, respectively (p<0.001). Moreover, the increased mandibular BMD in the 120 mg/kg equisetum arvense group was significantly higher than in the control group (p<0.01). Conclusion: A diet containing 120 mg/kg equisetum arvense extract resulted in increased mandibular bone mineral density. SN - 2008-6164 UR - https://www.unboundmedicine.com/medline/citation/31363396/Effect_of_equisetum_arvense_extract_on_bone_mineral_density_in_Wistar_rats_via_digital_radiography L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31363396/ DB - PRIME DP - Unbound Medicine ER -