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Second-to-fourth digit ratio and seborrheic dermatitis in males: a cross-sectional study.
An Bras Dermatol. 2019 Jul 29; 94(3):327-330.AB

Abstract

BACKGROUND

Seborrheic dermatitis is a common disease characterized by the erythematous plaques with oily-yellow desquamation. Increased sebaceous gland activity by androgenic hormones has played a role in the etiology of the disease. The second-to-fourth digit (2D:4D) ratio is thought to be a marker of prenatal androgen exposure.

OBJECTIVES

To investigate the association between 2D:4D ratios and seborrheic dermatitis in a male population.

METHODS

Healthy male controls and patients with seborrheic dermatitis were included in this study. One hundred seborrheic dermatitis patients and 120 healthy controls, aged 17-59, were enrolled. A digital Vernier caliper was used to measure the finger lengths. Seborrheic dermatitis severity was assessed using the Seborrheic Dermatitis Area and Severity Index (SDASI).

RESULTS

The 2D:4D ratios of the patients (x = 0.977) were significantly lower than those of the controls (x = 1.050) for right hands (t = 6.948; p = 0.000; > 0.05). No similar relationship was found between the 2D:4D ratio for left hands (t = 0.901; p = 0.368; > 0.05). Seborrheic dermatitis severity was negatively correlated with 2D:4D ratios of right hands (r = -0.391; p = 0.000-0.05).

STUDY LIMITATIONS

One of the main limitations of this study was the small sample, which got a head of us from acquiring certain findings about the 2D:4D ratio and seborrheic dermatitis. The other limitation is that the patient selection did not reflect the general population, as a single clinic was studied.

CONCLUSION

To the authors' knowledge, this is the first study examining the relationship between 2D:4D ratios and seborrheic dermatitis. The result of this study may indicate a line of investigation and can support the theory of prenatal androgen exposure.

Authors+Show Affiliations

Department of Dermatology, School of Medicine, Selcuk University, Konya, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31365662

Citation

İslamoğlu, Zeynep Gizem Kaya. "Second-to-fourth Digit Ratio and Seborrheic Dermatitis in Males: a Cross-sectional Study." Anais Brasileiros De Dermatologia, vol. 94, no. 3, 2019, pp. 327-330.
İslamoğlu ZGK. Second-to-fourth digit ratio and seborrheic dermatitis in males: a cross-sectional study. An Bras Dermatol. 2019;94(3):327-330.
İslamoğlu, Z. G. K. (2019). Second-to-fourth digit ratio and seborrheic dermatitis in males: a cross-sectional study. Anais Brasileiros De Dermatologia, 94(3), 327-330. https://doi.org/10.1590/abd1806-4841.20198578
İslamoğlu ZGK. Second-to-fourth Digit Ratio and Seborrheic Dermatitis in Males: a Cross-sectional Study. An Bras Dermatol. 2019 Jul 29;94(3):327-330. PubMed PMID: 31365662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Second-to-fourth digit ratio and seborrheic dermatitis in males: a cross-sectional study. A1 - İslamoğlu,Zeynep Gizem Kaya, Y1 - 2019/07/29/ PY - 2018/06/27/received PY - 2018/08/30/accepted PY - 2019/8/1/entrez PY - 2019/8/1/pubmed PY - 2019/9/4/medline SP - 327 EP - 330 JF - Anais brasileiros de dermatologia JO - An Bras Dermatol VL - 94 IS - 3 N2 - BACKGROUND: Seborrheic dermatitis is a common disease characterized by the erythematous plaques with oily-yellow desquamation. Increased sebaceous gland activity by androgenic hormones has played a role in the etiology of the disease. The second-to-fourth digit (2D:4D) ratio is thought to be a marker of prenatal androgen exposure. OBJECTIVES: To investigate the association between 2D:4D ratios and seborrheic dermatitis in a male population. METHODS: Healthy male controls and patients with seborrheic dermatitis were included in this study. One hundred seborrheic dermatitis patients and 120 healthy controls, aged 17-59, were enrolled. A digital Vernier caliper was used to measure the finger lengths. Seborrheic dermatitis severity was assessed using the Seborrheic Dermatitis Area and Severity Index (SDASI). RESULTS: The 2D:4D ratios of the patients (x = 0.977) were significantly lower than those of the controls (x = 1.050) for right hands (t = 6.948; p = 0.000; > 0.05). No similar relationship was found between the 2D:4D ratio for left hands (t = 0.901; p = 0.368; > 0.05). Seborrheic dermatitis severity was negatively correlated with 2D:4D ratios of right hands (r = -0.391; p = 0.000-0.05). STUDY LIMITATIONS: One of the main limitations of this study was the small sample, which got a head of us from acquiring certain findings about the 2D:4D ratio and seborrheic dermatitis. The other limitation is that the patient selection did not reflect the general population, as a single clinic was studied. CONCLUSION: To the authors' knowledge, this is the first study examining the relationship between 2D:4D ratios and seborrheic dermatitis. The result of this study may indicate a line of investigation and can support the theory of prenatal androgen exposure. SN - 1806-4841 UR - https://www.unboundmedicine.com/medline/citation/31365662/Second_to_fourth_digit_ratio_and_seborrheic_dermatitis_in_males:_a_cross_sectional_study_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31365662/ DB - PRIME DP - Unbound Medicine ER -