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Snake fang-inspired stamping patch for transdermal delivery of liquid formulations.
Sci Transl Med 2019; 11(503)ST

Abstract

A flexible microneedle patch that can transdermally deliver liquid-phase therapeutics would enable direct use of existing, approved drugs and vaccines, which are mostly in liquid form, without the need for additional drug solidification, efficacy verification, and subsequent approval. Specialized dissolving or coated microneedle patches that deliver reformulated, solidified therapeutics have made considerable advances; however, microneedles that can deliver liquid drugs and vaccines still remain elusive because of technical limitations. Here, we present a snake fang-inspired microneedle patch that can administer existing liquid formulations to patients in an ultrafast manner (<15 s). Rear-fanged snakes have an intriguing molar with a groove on the surface, which enables rapid and efficient infusion of venom or saliva into prey. Liquid delivery is based on surface tension and capillary action. The microneedle patch uses multiple open groove architectures that emulate the grooved fangs of rear-fanged snakes: Similar to snake fangs, the microneedles can rapidly and efficiently deliver diverse liquid-phase drugs and vaccines in seconds under capillary action with only gentle thumb pressure, without requiring a complex pumping system. Hydrodynamic simulations show that the snake fang-inspired open groove architectures enable rapid capillary force-driven delivery of liquid formulations with varied surface tensions and viscosities. We demonstrate that administration of ovalbumin and influenza virus with the snake fang-inspired microneedle patch induces robust antibody production and protective immune response in guinea pigs and mice.

Authors+Show Affiliations

Department of Electrical Engineering, Soongsil University, Seoul 06978, Republic of Korea. hoonejeong@unist.ac.kr wgbae@ssu.ac.kr.Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.Department of Electrical Engineering, Soongsil University, Seoul 06978, Republic of Korea.Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.Department of Electrical Engineering, Soongsil University, Seoul 06978, Republic of Korea.Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269, USA.Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.Department of Electrical Engineering, Soongsil University, Seoul 06978, Republic of Korea.Department of Mechanical Engineering, Soongsil University, Seoul 06978, Republic of Korea.School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 08826, Republic of Korea.Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea. hoonejeong@unist.ac.kr wgbae@ssu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31366579

Citation

Bae, Won-Gyu, et al. "Snake Fang-inspired Stamping Patch for Transdermal Delivery of Liquid Formulations." Science Translational Medicine, vol. 11, no. 503, 2019.
Bae WG, Ko H, So JY, et al. Snake fang-inspired stamping patch for transdermal delivery of liquid formulations. Sci Transl Med. 2019;11(503).
Bae, W. G., Ko, H., So, J. Y., Yi, H., Lee, C. H., Lee, D. H., ... Jeong, H. E. (2019). Snake fang-inspired stamping patch for transdermal delivery of liquid formulations. Science Translational Medicine, 11(503), doi:10.1126/scitranslmed.aaw3329.
Bae WG, et al. Snake Fang-inspired Stamping Patch for Transdermal Delivery of Liquid Formulations. Sci Transl Med. 2019 Jul 31;11(503) PubMed PMID: 31366579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Snake fang-inspired stamping patch for transdermal delivery of liquid formulations. AU - Bae,Won-Gyu, AU - Ko,Hangil, AU - So,Jin-Young, AU - Yi,Hoon, AU - Lee,Chan-Ho, AU - Lee,Dong-Hun, AU - Ahn,Yujin, AU - Lee,Sang-Hyeon, AU - Lee,Kyunghun, AU - Jun,Joonha, AU - Kim,Hyoung-Ho, AU - Jeon,Noo Li, AU - Jung,Woonggyu, AU - Song,Chang-Seon, AU - Kim,Taesung, AU - Kim,Yeu-Chun, AU - Jeong,Hoon Eui, PY - 2018/12/10/received PY - 2019/06/10/accepted PY - 2019/8/2/entrez JF - Science translational medicine JO - Sci Transl Med VL - 11 IS - 503 N2 - A flexible microneedle patch that can transdermally deliver liquid-phase therapeutics would enable direct use of existing, approved drugs and vaccines, which are mostly in liquid form, without the need for additional drug solidification, efficacy verification, and subsequent approval. Specialized dissolving or coated microneedle patches that deliver reformulated, solidified therapeutics have made considerable advances; however, microneedles that can deliver liquid drugs and vaccines still remain elusive because of technical limitations. Here, we present a snake fang-inspired microneedle patch that can administer existing liquid formulations to patients in an ultrafast manner (<15 s). Rear-fanged snakes have an intriguing molar with a groove on the surface, which enables rapid and efficient infusion of venom or saliva into prey. Liquid delivery is based on surface tension and capillary action. The microneedle patch uses multiple open groove architectures that emulate the grooved fangs of rear-fanged snakes: Similar to snake fangs, the microneedles can rapidly and efficiently deliver diverse liquid-phase drugs and vaccines in seconds under capillary action with only gentle thumb pressure, without requiring a complex pumping system. Hydrodynamic simulations show that the snake fang-inspired open groove architectures enable rapid capillary force-driven delivery of liquid formulations with varied surface tensions and viscosities. We demonstrate that administration of ovalbumin and influenza virus with the snake fang-inspired microneedle patch induces robust antibody production and protective immune response in guinea pigs and mice. SN - 1946-6242 UR - https://www.unboundmedicine.com/medline/citation/31366579/Snake_fang-inspired_stamping_patch_for_transdermal_delivery_of_liquid_formulations L2 - http://stm.sciencemag.org/cgi/pmidlookup?view=short&amp;pmid=31366579 DB - PRIME DP - Unbound Medicine ER -