Tags

Type your tag names separated by a space and hit enter

A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis.
Clin Immunol. 2019 10; 207:87-96.CI

Abstract

Anti-human cytomegalovirus (HCMV) antibodies are considered triggers of systemic sclerosis (SSc), but such a hypothesis has been assessed in limited sub-dominant epitopes. Our aim was to systematically assess the potential association of HCMV antibodies targeting most immunodominant and subdominant viral antigens, as this would reveal immunopathogenic associations. Our study included 110 SSc patients, 60 multiple sclerosis (MS) patients, and 51 healthy controls (HC). Anti-HCMV abs were tested by immunoblotting. IgG anti-HCMV was broader in SSc and MS compared to HC. Anti- UL57 and UL55 were more frequent in SSc versus MS forms. Reactivity to multiple viral antigens was more frequent in SSc than MS forms. Anti-viral antibodies levels were higher in specific autoantibody-positive SSc patients compared to seronegative cases. In conclusion, more prevalent and/or stronger antigen-specific HCMV responses are noted in SSc compared to controls, implying a role of these viral responses in SSc development.

Authors+Show Affiliations

Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University General Hospital, University of Thessaly Viopolis, Larissa, Greece.Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University General Hospital, University of Thessaly Viopolis, Larissa, Greece.Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University General Hospital, University of Thessaly Viopolis, Larissa, Greece.Institute of Immunology, EUROIMMUN, Lubeck, Germany.Institute of Immunology, EUROIMMUN, Lubeck, Germany.Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.Department of Rheumatology, Patras University Hospital, Faculty of Medicine, University of Patras, Greece.Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University General Hospital, University of Thessaly Viopolis, Larissa, Greece; Institute of Immunology, EUROIMMUN, Lubeck, Germany.Institute of Immunology, EUROIMMUN, Lubeck, Germany. Electronic address: lsakkas@med.uth.gr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31369821

Citation

Efthymiou, Georgios, et al. "A Comprehensive Analysis of Antigen-specific Antibody Responses Against Human Cytomegalovirus in Patients With Systemic Sclerosis." Clinical Immunology (Orlando, Fla.), vol. 207, 2019, pp. 87-96.
Efthymiou G, Dardiotis E, Liaskos C, et al. A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis. Clin Immunol. 2019;207:87-96.
Efthymiou, G., Dardiotis, E., Liaskos, C., Marou, E., Scheper, T., Meyer, W., Daponte, A., Daoussis, D., Hadjigeorgiou, G., Bogdanos, D. P., & Sakkas, L. I. (2019). A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis. Clinical Immunology (Orlando, Fla.), 207, 87-96. https://doi.org/10.1016/j.clim.2019.07.012
Efthymiou G, et al. A Comprehensive Analysis of Antigen-specific Antibody Responses Against Human Cytomegalovirus in Patients With Systemic Sclerosis. Clin Immunol. 2019;207:87-96. PubMed PMID: 31369821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis. AU - Efthymiou,Georgios, AU - Dardiotis,Efthymios, AU - Liaskos,Christos, AU - Marou,Emmanouela, AU - Scheper,Thomas, AU - Meyer,Wolfgang, AU - Daponte,Alexandros, AU - Daoussis,Dimitrios, AU - Hadjigeorgiou,Georgios, AU - Bogdanos,Dimitrios P, AU - Sakkas,Lazaros I, Y1 - 2019/07/29/ PY - 2019/03/07/received PY - 2019/05/23/revised PY - 2019/07/26/accepted PY - 2019/8/2/pubmed PY - 2020/5/19/medline PY - 2019/8/2/entrez SP - 87 EP - 96 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 207 N2 - Anti-human cytomegalovirus (HCMV) antibodies are considered triggers of systemic sclerosis (SSc), but such a hypothesis has been assessed in limited sub-dominant epitopes. Our aim was to systematically assess the potential association of HCMV antibodies targeting most immunodominant and subdominant viral antigens, as this would reveal immunopathogenic associations. Our study included 110 SSc patients, 60 multiple sclerosis (MS) patients, and 51 healthy controls (HC). Anti-HCMV abs were tested by immunoblotting. IgG anti-HCMV was broader in SSc and MS compared to HC. Anti- UL57 and UL55 were more frequent in SSc versus MS forms. Reactivity to multiple viral antigens was more frequent in SSc than MS forms. Anti-viral antibodies levels were higher in specific autoantibody-positive SSc patients compared to seronegative cases. In conclusion, more prevalent and/or stronger antigen-specific HCMV responses are noted in SSc compared to controls, implying a role of these viral responses in SSc development. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/31369821/A_comprehensive_analysis_of_antigen_specific_antibody_responses_against_human_cytomegalovirus_in_patients_with_systemic_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(19)30129-9 DB - PRIME DP - Unbound Medicine ER -