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Risk of spontaneous preterm labor in pregnancies achieved by in vitro fertilization and complicated with severe form of ovarian hyperstimulation syndrome: A case control study.
Pak J Med Sci 2019 Jul-Aug; 35(4):923-928PJ

Abstract

Objectives

The purpose of this study was to examine the potential impact of severe Ovarian hyper stimulation syndrome (OHSS) on the risk of preterm birth. Severe ovarian hyperstimulation syndrome is a serious complication in the methods of in vitro fertilization. The pathophysiology of this process is not clear enough and the treatment is symptomatic. Human chorionic gonadotropin (h-CG) is the most important known cause of this condition. Findings of other authors often do not match when it comes to complications that may occur in pregnancy.

Methods

In the Gynecology and Obstetrics Clinic "Narodni Front" a case control study was conducted on 50 female patients with severe forms of OHSS in the period from January 2008 to March 2015. A control group was created based on age and it involved 59 patients with pregnancy achieved with IVF/ICSI during the same period, but in which OHSS did not occur.

Results

Patients with the pregnancy complicated by OHSS, had a considerably higher rate of preterm labor, whether this was labor before gestation week 37 (56.0% vs. 30.5%) or before gestation week 34 (34.0% vs. 6.8%); significantly lower weight of newborns, as in the newborns with low body weight <2500g (45.6% vs. 25.0%) and specially in the newborn with very low body weight <1500 grams (19.1% vs. 3.8%), as well as preterm premature rupture of membranes (PPROM), (11.76% vs. 1.59%).

Conclusions

Pregnancy achieved by the IVF/ICSI method in which severe form of OHSS has been developed could have an increased risk of preterm birth.

Authors+Show Affiliations

Dr. Aleksandar Dobrosavljevic, Obstetrician and Gynecologist, The Obstetrics and Gynecology Clinic Narodni Front, Kraljice Natalije 62, 11000 Belgrade, Serbia.Dr. Snezana Rakic, Professor of Obstetrics and Gynaecology, The Obstetrics and Gynecology Clinic Narodni Front, Kraljice Natalije 62, 11000 Belgrade, Serbia. University of Belgrade School of Medicine, Dr Subotica 8, Serbia.Sladjana Mihajlovic, Assistant Professor of Obstetrics and Gynaecology, The Obstetrics and Gynecology Clinic Narodni Front, Kraljice Natalije 62, 11000 Belgrade, Serbia. University of Belgrade School of Medicine, Dr Subotica 8, Serbia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31372118

Citation

Dobrosavljevic, Aleksandar, et al. "Risk of Spontaneous Preterm Labor in Pregnancies Achieved By in Vitro Fertilization and Complicated With Severe Form of Ovarian Hyperstimulation Syndrome: a Case Control Study." Pakistan Journal of Medical Sciences, vol. 35, no. 4, 2019, pp. 923-928.
Dobrosavljevic A, Rakic S, Mihajlovic S. Risk of spontaneous preterm labor in pregnancies achieved by in vitro fertilization and complicated with severe form of ovarian hyperstimulation syndrome: A case control study. Pak J Med Sci. 2019;35(4):923-928.
Dobrosavljevic, A., Rakic, S., & Mihajlovic, S. (2019). Risk of spontaneous preterm labor in pregnancies achieved by in vitro fertilization and complicated with severe form of ovarian hyperstimulation syndrome: A case control study. Pakistan Journal of Medical Sciences, 35(4), pp. 923-928. doi:10.12669/pjms.35.4.145.
Dobrosavljevic A, Rakic S, Mihajlovic S. Risk of Spontaneous Preterm Labor in Pregnancies Achieved By in Vitro Fertilization and Complicated With Severe Form of Ovarian Hyperstimulation Syndrome: a Case Control Study. Pak J Med Sci. 2019;35(4):923-928. PubMed PMID: 31372118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of spontaneous preterm labor in pregnancies achieved by in vitro fertilization and complicated with severe form of ovarian hyperstimulation syndrome: A case control study. AU - Dobrosavljevic,Aleksandar, AU - Rakic,Snezana, AU - Mihajlovic,Sladjana, PY - 2019/8/3/entrez PY - 2019/8/3/pubmed PY - 2019/8/3/medline KW - IVF/ICSI KW - Ovarian hyper stimulation syndrome KW - Preterm birth SP - 923 EP - 928 JF - Pakistan journal of medical sciences JO - Pak J Med Sci VL - 35 IS - 4 N2 - Objectives: The purpose of this study was to examine the potential impact of severe Ovarian hyper stimulation syndrome (OHSS) on the risk of preterm birth. Severe ovarian hyperstimulation syndrome is a serious complication in the methods of in vitro fertilization. The pathophysiology of this process is not clear enough and the treatment is symptomatic. Human chorionic gonadotropin (h-CG) is the most important known cause of this condition. Findings of other authors often do not match when it comes to complications that may occur in pregnancy. Methods: In the Gynecology and Obstetrics Clinic "Narodni Front" a case control study was conducted on 50 female patients with severe forms of OHSS in the period from January 2008 to March 2015. A control group was created based on age and it involved 59 patients with pregnancy achieved with IVF/ICSI during the same period, but in which OHSS did not occur. Results: Patients with the pregnancy complicated by OHSS, had a considerably higher rate of preterm labor, whether this was labor before gestation week 37 (56.0% vs. 30.5%) or before gestation week 34 (34.0% vs. 6.8%); significantly lower weight of newborns, as in the newborns with low body weight <2500g (45.6% vs. 25.0%) and specially in the newborn with very low body weight <1500 grams (19.1% vs. 3.8%), as well as preterm premature rupture of membranes (PPROM), (11.76% vs. 1.59%). Conclusions: Pregnancy achieved by the IVF/ICSI method in which severe form of OHSS has been developed could have an increased risk of preterm birth. SN - 1682-024X UR - https://www.unboundmedicine.com/medline/citation/31372118/Risk_of_spontaneous_preterm_labor_in_pregnancies_achieved_by_in_vitro_fertilization_and_complicated_with_severe_form_of_ovarian_hyperstimulation_syndrome:_A_case_control_study L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31372118/ DB - PRIME DP - Unbound Medicine ER -