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An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body.
Cell Prolif 2019; :e12667CP

Abstract

OBJECTIVE

Interstitial fluid in extracellular matrices may not be totally fixed but partially flow through long-distance oriented fibrous connective tissues via physical mechanisms. We hypothesized there is a long-distance interstitial fluid transport network beyond vascular circulations.

MATERIALS AND METHODS

We first used 20 volunteers to determine hypodermic entrant points to visualize long-distance extravascular pathway by MRI. We then investigated the extravascular pathways initiating from the point of thumb in cadavers by chest compressor. The distributions and structures of long-distance pathways from extremity ending to associated visceral structures were identified.

RESULTS

Using fluorescent tracer, the pathways from right thumb to right atrium wall near chest were visualized in seven of 10 subjects. The cutaneous pathways were found in dermic, hypodermic and fascial tissues of hand and forearm. The perivascular pathways were along the veins of arm, axillary sheath, superior vena cava and into the superficial tissues on right atrium. Histological and micro-CT data showed these pathways were neither blood nor lymphatic vessels but long-distance oriented fibrous matrices, which contained the longitudinally assembled micro-scale fibres consistently from thumb to superficial tissues on right atrium.

CONCLUSIONS

These data revealed the structural framework of the fibrous extracellular matrices in oriented fibrous connective tissues was of the long-distance assembled fibres throughout human body. Along fibres, interstitial fluid can systemically transport by certain driving-transfer mechanisms beyond vascular circulations.

Authors+Show Affiliations

Beijing Hospital, National Center of Gerontology, Beijing, China.Beijing Hospital, National Center of Gerontology, Beijing, China.Department of Engineering Mechanics, Tsinghua University, Beijing, China.Beijing Hospital, National Center of Gerontology, Beijing, China.Beijing Hospital, National Center of Gerontology, Beijing, China.Beijing Hospital, National Center of Gerontology, Beijing, China.Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China. School of Basic Medicine, Peking Union Medical College, Beijing, China.Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China. School of Basic Medicine, Peking Union Medical College, Beijing, China.Beijing Hospital, National Center of Gerontology, Beijing, China.Beijing Hospital, National Center of Gerontology, Beijing, China.Beijing Hospital, National Center of Gerontology, Beijing, China.Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China. School of Basic Medicine, Peking Union Medical College, Beijing, China.National Center for Nanoscience and Technology, Beijing, China.National Center for Nanoscience and Technology, Beijing, China.National Center for Nanoscience and Technology, Beijing, China.National Center for Nanoscience and Technology, Beijing, China.Department of Human Anatomy, Histology and Embryology, Neuroscience Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China. School of Basic Medicine, Peking Union Medical College, Beijing, China.School of Chemistry and Biosciences, University of Bradford, Bradford, UK.National Center for Nanoscience and Technology, Beijing, China.Beijing Hospital, National Center of Gerontology, Beijing, China.Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31373101

Citation

Li, Hongyi, et al. "An Extravascular Fluid Transport System Based On Structural Framework of Fibrous Connective Tissues in Human Body." Cell Proliferation, 2019, pp. e12667.
Li H, Yang C, Yin Y, et al. An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body. Cell Prolif. 2019.
Li, H., Yang, C., Yin, Y., Wang, F., Chen, M., Xu, L., ... Li, H. (2019). An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body. Cell Proliferation, pp. e12667. doi:10.1111/cpr.12667.
Li H, et al. An Extravascular Fluid Transport System Based On Structural Framework of Fibrous Connective Tissues in Human Body. Cell Prolif. 2019 Aug 1;e12667. PubMed PMID: 31373101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An extravascular fluid transport system based on structural framework of fibrous connective tissues in human body. AU - Li,Hongyi, AU - Yang,Chongqing, AU - Yin,Yajun, AU - Wang,Fang, AU - Chen,Min, AU - Xu,Liang, AU - Wang,Naili, AU - Zhang,Di, AU - Wang,Xiaoxia, AU - Kong,Yiya, AU - Li,Qing, AU - Su,Si, AU - Cao,Yupeng, AU - Liu,Wentao, AU - Ao,Zhuo, AU - Dai,Luru, AU - Ma,Chao, AU - Shang,Lijun, AU - Han,Dong, AU - Ji,Fusui, AU - Li,Hua, Y1 - 2019/08/01/ PY - 2019/06/03/received PY - 2019/06/14/revised PY - 2019/06/19/accepted PY - 2019/8/3/entrez KW - extracellular matrix KW - fibrous connective tissues KW - gross anatomy KW - interfacial transport KW - interstitial fluid SP - e12667 EP - e12667 JF - Cell proliferation JO - Cell Prolif. N2 - OBJECTIVE: Interstitial fluid in extracellular matrices may not be totally fixed but partially flow through long-distance oriented fibrous connective tissues via physical mechanisms. We hypothesized there is a long-distance interstitial fluid transport network beyond vascular circulations. MATERIALS AND METHODS: We first used 20 volunteers to determine hypodermic entrant points to visualize long-distance extravascular pathway by MRI. We then investigated the extravascular pathways initiating from the point of thumb in cadavers by chest compressor. The distributions and structures of long-distance pathways from extremity ending to associated visceral structures were identified. RESULTS: Using fluorescent tracer, the pathways from right thumb to right atrium wall near chest were visualized in seven of 10 subjects. The cutaneous pathways were found in dermic, hypodermic and fascial tissues of hand and forearm. The perivascular pathways were along the veins of arm, axillary sheath, superior vena cava and into the superficial tissues on right atrium. Histological and micro-CT data showed these pathways were neither blood nor lymphatic vessels but long-distance oriented fibrous matrices, which contained the longitudinally assembled micro-scale fibres consistently from thumb to superficial tissues on right atrium. CONCLUSIONS: These data revealed the structural framework of the fibrous extracellular matrices in oriented fibrous connective tissues was of the long-distance assembled fibres throughout human body. Along fibres, interstitial fluid can systemically transport by certain driving-transfer mechanisms beyond vascular circulations. SN - 1365-2184 UR - https://www.unboundmedicine.com/medline/citation/31373101/An_extravascular_fluid_transport_system_based_on_structural_framework_of_fibrous_connective_tissues_in_human_body L2 - https://doi.org/10.1111/cpr.12667 DB - PRIME DP - Unbound Medicine ER -