Tags

Type your tag names separated by a space and hit enter

Influence of Age on Global and Regional Brain Stiffness in Young and Middle-Aged Adults.

Abstract

BACKGROUND

An understanding of potential age-related changes in brain stiffness and its regional variation is important for further clinical application of MR elastography.

PURPOSE

To investigate the effect of age on global and regional brain stiffness in young and middle-aged adults.

STUDY TYPE

Prospective.

SUBJECTS

Fifty subjects with normal brains and aged in their 20s, 30s, 40s, 50s, or 60s (five men, five women per decade).

FIELD STRENGTH/SEQUENCE

3.0T MRI and elastography with a vibration frequency of 60 Hz.

ASSESSMENT

Stiffness was measured in nine brain regions (cerebrum, temporal lobes, sensorimotor areas, frontotemporal composite region, deep gray matter and white matter (deep GM/WM), parietal lobes, occipital lobes, frontal lobes, and cerebellum) using an atlas-based region-of-interest approach. The influence of age on regional brain stiffness was evaluated.

STATISTICAL TESTS

Multiple linear regression analysis, followed by Dunnett's multiple comparisons test, using subjects in their 20s as controls.

RESULTS

Following adjustment for sex, multiple linear regression revealed a significant negative correlation between age and stiffness of the cerebrum (P < 0.0001), temporal lobes (P < 0.0001), sensorimotor areas (P < 0.0001), frontotemporal composite region (P < 0.0001), deep GM/WM (P = 0.0028), parietal lobes (P < 0.0001), occipital lobes (P = 0.0055), and frontal lobes (P < 0.0001). Dunnett's multiple comparison test showed that the stiffness of the sensorimotor areas, frontotemporal composite region, and frontal lobes was significantly decreased in subjects in their 40s (P < 0.0367), 50s (P < 0.0001), and 60s (P < 0.0001), while that of the cerebrum, temporal lobes, and parietal lobes was significantly decreased only in subjects in their 50s (P < 0.0012) and 60s (P < 0.0031) when compared with the controls.

DATA CONCLUSION

There is an age-related decrease in brain stiffness that varies across the different regions.

LEVEL OF EVIDENCE

1 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019.

Authors+Show Affiliations

The Department of Radiology, University of Yamanashi, Yamanashi, Japan.The Department of Radiology, University of Yamanashi, Yamanashi, Japan.Department of Radiology, Shizuoka General Hospital, Shizuoka, Japan.Division of Radiology, University of Yamanashi Hospital, Yamanashi, Japan.Division of Radiology, University of Yamanashi Hospital, Yamanashi, Japan.Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.The Department of Radiology, University of Yamanashi, Yamanashi, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31373136

Citation

Takamura, Tomohiro, et al. "Influence of Age On Global and Regional Brain Stiffness in Young and Middle-Aged Adults." Journal of Magnetic Resonance Imaging : JMRI, 2019.
Takamura T, Motosugi U, Sasaki Y, et al. Influence of Age on Global and Regional Brain Stiffness in Young and Middle-Aged Adults. J Magn Reson Imaging. 2019.
Takamura, T., Motosugi, U., Sasaki, Y., Kakegawa, T., Sato, K., Glaser, K. J., ... Onishi, H. (2019). Influence of Age on Global and Regional Brain Stiffness in Young and Middle-Aged Adults. Journal of Magnetic Resonance Imaging : JMRI, doi:10.1002/jmri.26881.
Takamura T, et al. Influence of Age On Global and Regional Brain Stiffness in Young and Middle-Aged Adults. J Magn Reson Imaging. 2019 Aug 1; PubMed PMID: 31373136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of Age on Global and Regional Brain Stiffness in Young and Middle-Aged Adults. AU - Takamura,Tomohiro, AU - Motosugi,Utaroh, AU - Sasaki,Yu, AU - Kakegawa,Takashi, AU - Sato,Kazuyuki, AU - Glaser,Kevin J, AU - Ehman,Richard L, AU - Onishi,Hiroshi, Y1 - 2019/08/01/ PY - 2019/04/17/received PY - 2019/07/12/revised PY - 2019/07/12/accepted PY - 2019/8/3/entrez KW - age-related KW - brain stiffness KW - global KW - magnetic resonance elastography KW - magnetic resonance imaging KW - regional JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging N2 - BACKGROUND: An understanding of potential age-related changes in brain stiffness and its regional variation is important for further clinical application of MR elastography. PURPOSE: To investigate the effect of age on global and regional brain stiffness in young and middle-aged adults. STUDY TYPE: Prospective. SUBJECTS: Fifty subjects with normal brains and aged in their 20s, 30s, 40s, 50s, or 60s (five men, five women per decade). FIELD STRENGTH/SEQUENCE: 3.0T MRI and elastography with a vibration frequency of 60 Hz. ASSESSMENT: Stiffness was measured in nine brain regions (cerebrum, temporal lobes, sensorimotor areas, frontotemporal composite region, deep gray matter and white matter (deep GM/WM), parietal lobes, occipital lobes, frontal lobes, and cerebellum) using an atlas-based region-of-interest approach. The influence of age on regional brain stiffness was evaluated. STATISTICAL TESTS: Multiple linear regression analysis, followed by Dunnett's multiple comparisons test, using subjects in their 20s as controls. RESULTS: Following adjustment for sex, multiple linear regression revealed a significant negative correlation between age and stiffness of the cerebrum (P < 0.0001), temporal lobes (P < 0.0001), sensorimotor areas (P < 0.0001), frontotemporal composite region (P < 0.0001), deep GM/WM (P = 0.0028), parietal lobes (P < 0.0001), occipital lobes (P = 0.0055), and frontal lobes (P < 0.0001). Dunnett's multiple comparison test showed that the stiffness of the sensorimotor areas, frontotemporal composite region, and frontal lobes was significantly decreased in subjects in their 40s (P < 0.0367), 50s (P < 0.0001), and 60s (P < 0.0001), while that of the cerebrum, temporal lobes, and parietal lobes was significantly decreased only in subjects in their 50s (P < 0.0012) and 60s (P < 0.0031) when compared with the controls. DATA CONCLUSION: There is an age-related decrease in brain stiffness that varies across the different regions. LEVEL OF EVIDENCE: 1 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019. SN - 1522-2586 UR - https://www.unboundmedicine.com/medline/citation/31373136/Influence_of_Age_on_Global_and_Regional_Brain_Stiffness_in_Young_and_Middle-Aged_Adults L2 - https://doi.org/10.1002/jmri.26881 DB - PRIME DP - Unbound Medicine ER -