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The Essence of Systems Chemistry.
Life (Basel). 2019 Jul 11; 9(3)L

Abstract

Systems Chemistry investigates the upkeep of specific interactions of an exceptionally broad choice of objects over longer periods of time than the average time of existence of the objects themselves. This maintenance of a dynamic state focuses on conditions where the objects are thermodynamically not very stable and should be rare or virtually inexistent. It does not matter whether they are homochirally enriched populations of chiral molecules, a specific composition of some sort of aggregate, supramolecules, or even a set of chemically relatively unstable molecules that constantly transform one into another. What does matter is that these specific interactions prevail in complex mixtures and eventually grow in numbers and frequency through the enhancing action of autocatalysis, which makes such systems ultimately resemble living cells and interacting living populations. Such chemical systems need to be correctly understood, but also intuitively described. They may be so complex that metaphors become practically more important, as a means of communication, than the precise and correct technical description of chemical models and complex molecular or supramolecular relations. This puts systems chemists on a tightrope walk of science communication, between the complex reality and an imaginative model world. This essay addresses, both, scientists who would like to read "A Brief History of Systems Chemistry", that is, about its "essence", and systems chemists who work with and communicate complex life-like chemical systems. I illustrate for the external reader a light mantra, that I call "to make more of it", and I charily draw systems chemists to reflect upon the fact that chemists are not always good at drawing a clear line between a model and "the reality": The real thing. We are in a constant danger of taking metaphors for real. Yet in real life, we do know very well that we cannot smoke with Magritte's pipe, don't we?

Authors+Show Affiliations

Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (Unité Mixte de Recherche 5246), Université de Lyon, Claude Bernard Lyon 1, 43 bvd du 11 Novembre 1918, 69622 Villeurbanne CEDEX, France. strazewski@univ-lyon1.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31373279

Citation

Strazewski, Peter. "The Essence of Systems Chemistry." Life (Basel, Switzerland), vol. 9, no. 3, 2019.
Strazewski P. The Essence of Systems Chemistry. Life (Basel). 2019;9(3).
Strazewski, P. (2019). The Essence of Systems Chemistry. Life (Basel, Switzerland), 9(3). https://doi.org/10.3390/life9030060
Strazewski P. The Essence of Systems Chemistry. Life (Basel). 2019 Jul 11;9(3) PubMed PMID: 31373279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Essence of Systems Chemistry. A1 - Strazewski,Peter, Y1 - 2019/07/11/ PY - 2019/04/18/received PY - 2019/06/06/revised PY - 2019/06/25/accepted PY - 2019/8/3/entrez PY - 2019/8/3/pubmed PY - 2019/8/3/medline KW - human intervention KW - metaphors KW - origin of life KW - science communication JF - Life (Basel, Switzerland) JO - Life (Basel) VL - 9 IS - 3 N2 - Systems Chemistry investigates the upkeep of specific interactions of an exceptionally broad choice of objects over longer periods of time than the average time of existence of the objects themselves. This maintenance of a dynamic state focuses on conditions where the objects are thermodynamically not very stable and should be rare or virtually inexistent. It does not matter whether they are homochirally enriched populations of chiral molecules, a specific composition of some sort of aggregate, supramolecules, or even a set of chemically relatively unstable molecules that constantly transform one into another. What does matter is that these specific interactions prevail in complex mixtures and eventually grow in numbers and frequency through the enhancing action of autocatalysis, which makes such systems ultimately resemble living cells and interacting living populations. Such chemical systems need to be correctly understood, but also intuitively described. They may be so complex that metaphors become practically more important, as a means of communication, than the precise and correct technical description of chemical models and complex molecular or supramolecular relations. This puts systems chemists on a tightrope walk of science communication, between the complex reality and an imaginative model world. This essay addresses, both, scientists who would like to read "A Brief History of Systems Chemistry", that is, about its "essence", and systems chemists who work with and communicate complex life-like chemical systems. I illustrate for the external reader a light mantra, that I call "to make more of it", and I charily draw systems chemists to reflect upon the fact that chemists are not always good at drawing a clear line between a model and "the reality": The real thing. We are in a constant danger of taking metaphors for real. Yet in real life, we do know very well that we cannot smoke with Magritte's pipe, don't we? SN - 2075-1729 UR - https://www.unboundmedicine.com/medline/citation/31373279/The_Essence_of_Systems_Chemistry L2 - http://www.mdpi.com/resolver?pii=life9030060 DB - PRIME DP - Unbound Medicine ER -
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