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The effect of vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and testosterone deficiency.
Pharmacol Rep. 2019 Oct; 71(5):798-803.PR

Abstract

BACKGROUND

Autoimmune (Hashimoto's thyroiditis) is characterized by a strong female preponderance, which may suggest that sex hormones have an impact on thyroid autoimmunity. The aim of this study was to investigate whether testosterone determines vitamin D action on thyroid antibody titers and thyroid function tests in men with autoimmune thyroiditis and low testosterone levels.

METHODS

The study included 36 men with testosterone deficiency, 17 of whom had been treated for at least 26 weeks with oral testosterone undecanoate (120 mg daily). Because of coexistent euthyroid Hashimoto's thyroiditis, all participants were then treated with vitamin D (100 μg daily). Serum titers of thyroid peroxidase and thyroglobulin antibodies, serum levels of thyrotropin, free thyroid hormones, testosterone and 25-hydroxyvitamin D, as well as Jostel's thyrotropin index, SPINA-GT and SPINA-GD were assessed before vitamin D treatment and 26 weeks later.

RESULTS

With the exception of testosterone levels, there were no significant differences between both study groups in serum hormone levels, antibody titers and thyroid function tests. All participants completed the study. In addition to increasing 25-hydroxyvitamin D levels, vitamin D increased SPINA-GT and reduced thyroid peroxidase and thyroglobulin antibody titers. In testosterone-treated men, vitamin D increased testosterone levels. Vitamin D did not affect serum levels of thyrotropin, free thyroid hormones, Jostel's thyrotropin index and SPINA-GD. Treatment-induced changes in thyroid antibody titers and SPINA-GT were more pronounced in testosterone-treated than testosterone-naïve men.

CONCLUSIONS

The obtained results suggest that the beneficial effect on thyroid autoimmunity and thyroid secretory function is stronger in men receiving testosterone therapy.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. Electronic address: r.krysiak@interia.pl.Department of Paediatrics in Bytom, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31377561

Citation

Krysiak, Robert, et al. "The Effect of Vitamin D On Thyroid Autoimmunity in Euthyroid Men With Autoimmune Thyroiditis and Testosterone Deficiency." Pharmacological Reports : PR, vol. 71, no. 5, 2019, pp. 798-803.
Krysiak R, Kowalcze K, Okopień B. The effect of vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and testosterone deficiency. Pharmacol Rep. 2019;71(5):798-803.
Krysiak, R., Kowalcze, K., & Okopień, B. (2019). The effect of vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and testosterone deficiency. Pharmacological Reports : PR, 71(5), 798-803. https://doi.org/10.1016/j.pharep.2019.04.010
Krysiak R, Kowalcze K, Okopień B. The Effect of Vitamin D On Thyroid Autoimmunity in Euthyroid Men With Autoimmune Thyroiditis and Testosterone Deficiency. Pharmacol Rep. 2019;71(5):798-803. PubMed PMID: 31377561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and testosterone deficiency. AU - Krysiak,Robert, AU - Kowalcze,Karolina, AU - Okopień,Bogusław, Y1 - 2019/04/15/ PY - 2019/02/05/received PY - 2019/04/08/revised PY - 2019/04/13/accepted PY - 2019/8/5/pubmed PY - 2020/5/1/medline PY - 2019/8/5/entrez KW - Testosterone deficiency KW - Thyroid autoimmunity KW - Thyroid function tests KW - Vitamin D SP - 798 EP - 803 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 71 IS - 5 N2 - BACKGROUND: Autoimmune (Hashimoto's thyroiditis) is characterized by a strong female preponderance, which may suggest that sex hormones have an impact on thyroid autoimmunity. The aim of this study was to investigate whether testosterone determines vitamin D action on thyroid antibody titers and thyroid function tests in men with autoimmune thyroiditis and low testosterone levels. METHODS: The study included 36 men with testosterone deficiency, 17 of whom had been treated for at least 26 weeks with oral testosterone undecanoate (120 mg daily). Because of coexistent euthyroid Hashimoto's thyroiditis, all participants were then treated with vitamin D (100 μg daily). Serum titers of thyroid peroxidase and thyroglobulin antibodies, serum levels of thyrotropin, free thyroid hormones, testosterone and 25-hydroxyvitamin D, as well as Jostel's thyrotropin index, SPINA-GT and SPINA-GD were assessed before vitamin D treatment and 26 weeks later. RESULTS: With the exception of testosterone levels, there were no significant differences between both study groups in serum hormone levels, antibody titers and thyroid function tests. All participants completed the study. In addition to increasing 25-hydroxyvitamin D levels, vitamin D increased SPINA-GT and reduced thyroid peroxidase and thyroglobulin antibody titers. In testosterone-treated men, vitamin D increased testosterone levels. Vitamin D did not affect serum levels of thyrotropin, free thyroid hormones, Jostel's thyrotropin index and SPINA-GD. Treatment-induced changes in thyroid antibody titers and SPINA-GT were more pronounced in testosterone-treated than testosterone-naïve men. CONCLUSIONS: The obtained results suggest that the beneficial effect on thyroid autoimmunity and thyroid secretory function is stronger in men receiving testosterone therapy. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/31377561/The_effect_of_vitamin_D_on_thyroid_autoimmunity_in_euthyroid_men_with_autoimmune_thyroiditis_and_testosterone_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(19)30081-7 DB - PRIME DP - Unbound Medicine ER -