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Foveal avascular zone and macular vessel density after correction for magnification error in unilateral amblyopia using optical coherence tomography angiography.
BMC Ophthalmol. 2019 Aug 05; 19(1):171.BO

Abstract

BACKGROUND

To investigate the area of foveal avascular zone (FAZ) and macular vessel density (VD) after correction for magnification error in unilateral amblyopia using optical coherence tomography angiography (OCTA).

METHODS

Participants comprised 15 patients with unilateral amblyopia due to anisometropia with or without strabismus (mean age, 9.8 ± 3.4 years; range, 6-17 years). OCTA images were obtained by using spectral-domain OCT with angiography software. The OCTA scanning protocol used was 3 × 3-mm volume scan centered on the fovea. OCTA images were corrected for magnification errors using individual axial length (AL), and an adjusted 2.3 × 2.3-mm square was derived as a region of interest. The FAZ area and VD in both superficial capillary plexus (SCP) and deep capillary plexus (DCP) layers, foveal minimum thickness (FMT) were assessed using built-in OCTA software and ImageJ software (NIH, Bethesda, MD).

RESULTS

LogMAR in the amblyopic eyes was significantly poorer than that of the fellow eye (p < 0.001). AL was significantly shorter in the amblyopic eye than in the fellow eye (p < 0.001). FAZ area of SCP in amblyopic eyes was significantly smaller than that of fellow eyes (p < 0.001). No significant differences were seen in FAZ area of DCP, VD of SCP, VD of DCP, and FMT between amblyopic and fellow eyes (p = 0.07, 0.43, 0.55, and 0.25, respectively).

CONCLUSIONS

Our present study after magnification error correction found smaller FAZ area of SCP in the amblyopic eye compared with the fellow eyes, but there was no significant difference in the macular VD between the amblyopic and fellow eyes.

Authors+Show Affiliations

Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Doctoral Program in Sensory Science, Graduate School of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama, 701-0193, Japan.Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. amiki@tc5.so-net.ne.jp. Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama, 701-0193, Japan. amiki@tc5.so-net.ne.jp.Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama, 701-0193, Japan.Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama, 701-0193, Japan.Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama, 701-0193, Japan.Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.Department of Human Sciences, Kanagawa University, 3-27-1 Rokkakubashi, Yokohama, Kanagawa, 221-8686, Japan.Yaoeda Eye Clinic, 2-1649-1 Naga-Chou, Nagaoka, Niigata, 940-0053, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31382925

Citation

Araki, Syunsuke, et al. "Foveal Avascular Zone and Macular Vessel Density After Correction for Magnification Error in Unilateral Amblyopia Using Optical Coherence Tomography Angiography." BMC Ophthalmology, vol. 19, no. 1, 2019, p. 171.
Araki S, Miki A, Goto K, et al. Foveal avascular zone and macular vessel density after correction for magnification error in unilateral amblyopia using optical coherence tomography angiography. BMC Ophthalmol. 2019;19(1):171.
Araki, S., Miki, A., Goto, K., Yamashita, T., Yoneda, T., Haruishi, K., Ieki, Y., Kiryu, J., Maehara, G., & Yaoeda, K. (2019). Foveal avascular zone and macular vessel density after correction for magnification error in unilateral amblyopia using optical coherence tomography angiography. BMC Ophthalmology, 19(1), 171. https://doi.org/10.1186/s12886-019-1177-z
Araki S, et al. Foveal Avascular Zone and Macular Vessel Density After Correction for Magnification Error in Unilateral Amblyopia Using Optical Coherence Tomography Angiography. BMC Ophthalmol. 2019 Aug 5;19(1):171. PubMed PMID: 31382925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Foveal avascular zone and macular vessel density after correction for magnification error in unilateral amblyopia using optical coherence tomography angiography. AU - Araki,Syunsuke, AU - Miki,Atsushi, AU - Goto,Katsutoshi, AU - Yamashita,Tsutomu, AU - Yoneda,Tsuyoshi, AU - Haruishi,Kazuko, AU - Ieki,Yoshiaki, AU - Kiryu,Junichi, AU - Maehara,Goro, AU - Yaoeda,Kiyoshi, Y1 - 2019/08/05/ PY - 2019/04/17/received PY - 2019/07/24/accepted PY - 2019/8/7/entrez PY - 2019/8/7/pubmed PY - 2019/8/15/medline KW - Amblyopia KW - Foveal avascular zone KW - Macular vessel density KW - Optical coherence tomography angiography KW - Retina SP - 171 EP - 171 JF - BMC ophthalmology JO - BMC Ophthalmol VL - 19 IS - 1 N2 - BACKGROUND: To investigate the area of foveal avascular zone (FAZ) and macular vessel density (VD) after correction for magnification error in unilateral amblyopia using optical coherence tomography angiography (OCTA). METHODS: Participants comprised 15 patients with unilateral amblyopia due to anisometropia with or without strabismus (mean age, 9.8 ± 3.4 years; range, 6-17 years). OCTA images were obtained by using spectral-domain OCT with angiography software. The OCTA scanning protocol used was 3 × 3-mm volume scan centered on the fovea. OCTA images were corrected for magnification errors using individual axial length (AL), and an adjusted 2.3 × 2.3-mm square was derived as a region of interest. The FAZ area and VD in both superficial capillary plexus (SCP) and deep capillary plexus (DCP) layers, foveal minimum thickness (FMT) were assessed using built-in OCTA software and ImageJ software (NIH, Bethesda, MD). RESULTS: LogMAR in the amblyopic eyes was significantly poorer than that of the fellow eye (p < 0.001). AL was significantly shorter in the amblyopic eye than in the fellow eye (p < 0.001). FAZ area of SCP in amblyopic eyes was significantly smaller than that of fellow eyes (p < 0.001). No significant differences were seen in FAZ area of DCP, VD of SCP, VD of DCP, and FMT between amblyopic and fellow eyes (p = 0.07, 0.43, 0.55, and 0.25, respectively). CONCLUSIONS: Our present study after magnification error correction found smaller FAZ area of SCP in the amblyopic eye compared with the fellow eyes, but there was no significant difference in the macular VD between the amblyopic and fellow eyes. SN - 1471-2415 UR - https://www.unboundmedicine.com/medline/citation/31382925/Foveal_avascular_zone_and_macular_vessel_density_after_correction_for_magnification_error_in_unilateral_amblyopia_using_optical_coherence_tomography_angiography_ L2 - https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-019-1177-z DB - PRIME DP - Unbound Medicine ER -