Tags

Type your tag names separated by a space and hit enter

Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary.
Pharmacol Rep 2019; 71(5):833-838PR

Abstract

BACKGROUND

WAG/Rij rats represent a validated genetic animal model of epileptogenesis, absence epilepsy and depressive-like comorbidity. Some treatments (e.g. ethosuximide), using specific protocols, prevent the development of spontaneous absence seizures. Accordingly, ethosuximide increases remission occurrence in children with childhood absence epilepsy in comparison to valproic acid. Considering that in this animal model, antiepileptogenic effects are, in some cases, not retained over time, we studied whether the antiepileptogenic effects of both ethosuximide and levetiracetam (which also possesses antiepileptogenic effects in this and other animal epilepsy models) would be retained 5 months after drug suspension.

METHODS

WAG/Rij rats of ˜1 month of age were treated long-term with one of the two drugs at a dose of ˜80 mg/kg/day for 17 consecutive weeks; 1 and 5 months after drug suspension, the development of absence seizures as well as depressive-like behaviour were assessed by EEG recordings and the forced swimming test (FST).

RESULTS

In agreement with a previous report, both drugs continued to show antiepileptogenic effects 1 month after their discontinuation. Furthermore, ethosuximide improved depressive-like behaviour, whereas in contrast, levetiracetam worsened this symptom. However, none of the drugs maintained their antiepileptogenic effects 5 months after suspension, and in addition, animal behaviour in the FST returned to control conditions.

CONCLUSION

Overall, these results demonstrate that the antiepileptogenic effects of both ethosuximide and levetiracetam on absence seizure development and associated depressive-like behaviour in this model are only temporary.

Authors+Show Affiliations

University of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy.University of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy.University of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy.University of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy.University of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy; CNR, Institute of Neurological Sciences, Pharmacology Section, Roccelletta di Borgia, Catanzaro, Italy.CNR, Institute of Neurological Sciences, Pharmacology Section, Roccelletta di Borgia, Catanzaro, Italy.Department of Pharmacology, UCL School of Pharmacy, London, UK.University of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy.University of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy.University of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy. Electronic address: citraro@unicz.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31386986

Citation

Leo, Antonio, et al. "Antiepileptogenic Effects of Ethosuximide and Levetiracetam in WAG/Rij Rats Are Only Temporary." Pharmacological Reports : PR, vol. 71, no. 5, 2019, pp. 833-838.
Leo A, Caro C, Nesci V, et al. Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary. Pharmacol Rep. 2019;71(5):833-838.
Leo, A., Caro, C., Nesci, V., Palma, E., Tallarico, M., Iannone, M., ... Citraro, R. (2019). Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary. Pharmacological Reports : PR, 71(5), pp. 833-838. doi:10.1016/j.pharep.2019.04.017.
Leo A, et al. Antiepileptogenic Effects of Ethosuximide and Levetiracetam in WAG/Rij Rats Are Only Temporary. Pharmacol Rep. 2019;71(5):833-838. PubMed PMID: 31386986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiepileptogenic effects of Ethosuximide and Levetiracetam in WAG/Rij rats are only temporary. AU - Leo,Antonio, AU - Caro,Carmen De, AU - Nesci,Valentina, AU - Palma,Ernesto, AU - Tallarico,Martina, AU - Iannone,Michelangelo, AU - Constanti,Andrew, AU - Sarro,Giovambattista De, AU - Russo,Emilio, AU - Citraro,Rita, Y1 - 2019/04/24/ PY - 2018/12/30/received PY - 2019/03/22/revised PY - 2019/04/23/accepted PY - 2019/8/7/pubmed PY - 2019/8/7/medline PY - 2019/8/7/entrez KW - Absence epilepsy KW - Depressive behaviour KW - Epileptogenesis KW - Ethosuximide KW - Levetiracetam SP - 833 EP - 838 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 71 IS - 5 N2 - BACKGROUND: WAG/Rij rats represent a validated genetic animal model of epileptogenesis, absence epilepsy and depressive-like comorbidity. Some treatments (e.g. ethosuximide), using specific protocols, prevent the development of spontaneous absence seizures. Accordingly, ethosuximide increases remission occurrence in children with childhood absence epilepsy in comparison to valproic acid. Considering that in this animal model, antiepileptogenic effects are, in some cases, not retained over time, we studied whether the antiepileptogenic effects of both ethosuximide and levetiracetam (which also possesses antiepileptogenic effects in this and other animal epilepsy models) would be retained 5 months after drug suspension. METHODS: WAG/Rij rats of ˜1 month of age were treated long-term with one of the two drugs at a dose of ˜80 mg/kg/day for 17 consecutive weeks; 1 and 5 months after drug suspension, the development of absence seizures as well as depressive-like behaviour were assessed by EEG recordings and the forced swimming test (FST). RESULTS: In agreement with a previous report, both drugs continued to show antiepileptogenic effects 1 month after their discontinuation. Furthermore, ethosuximide improved depressive-like behaviour, whereas in contrast, levetiracetam worsened this symptom. However, none of the drugs maintained their antiepileptogenic effects 5 months after suspension, and in addition, animal behaviour in the FST returned to control conditions. CONCLUSION: Overall, these results demonstrate that the antiepileptogenic effects of both ethosuximide and levetiracetam on absence seizure development and associated depressive-like behaviour in this model are only temporary. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/31386986/Antiepileptogenic_effects_of_Ethosuximide_and_Levetiracetam_in_WAG/Rij_rats_are_only_temporary L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(18)30783-7 DB - PRIME DP - Unbound Medicine ER -