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Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms.
Acta Neurol Scand. 2019 Oct; 140(4):274-280.AN

Abstract

OBJECTIVES

Vitamin D deficiency is widespread in patients with Parkinson's disease (PD). Our aim was to determine whether serum vitamin D levels correlated with bone mineral density (BMD) and non-motor symptoms in patients with PD.

MATERIALS & METHODS

A consecutive series of 182 patients with PD and 185 healthy controls were included. Serum 25-hydroxyvitamin D (25[OH]D) levels were measured by immunoassay, while BMD of the lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry. Associations between serum vitamin D levels and clinical data were evaluated using partial correlation analysis.

RESULTS

Patients with PD had significantly lower serum 25(OH)D levels relative to healthy controls (49.75 ± 14.11 vs 43.40 ± 16.51, P < 0.001). Furthermore, PD patients with lower vitamin D levels had a significantly higher frequency of falls (P = 0.033) and insomnia (P = 0.015). They also had significantly higher scores for the Pittsburgh Sleep Quality Index (PSQI; P = 0.014), depression (P = 0.020), and anxiety (P = 0.009). Finally, patients with PD also had a significantly lower mean BMD of the lumbar spine (P = 0.011) and femoral neck (P < 0.001). After adjusting for age, sex, and body mass index, vitamin D levels significantly correlated with falls, insomnia, and scores for the PSQI, depression, and anxiety.

CONCLUSIONS

In patients with PD, vitamin D levels significantly correlated with falls and some non-motor symptoms. However, no associations were found between BMD and the serum 25(OH)D levels in patients with PD. Thus, vitamin D supplementation is a potential therapeutic for non-motor PD symptoms.

Authors+Show Affiliations

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, China.Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31389003

Citation

Zhang, Hui-Jun, et al. "Relationship Between 25-Hydroxyvitamin D, Bone Density, and Parkinson's Disease Symptoms." Acta Neurologica Scandinavica, vol. 140, no. 4, 2019, pp. 274-280.
Zhang HJ, Zhang JR, Mao CJ, et al. Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms. Acta Neurol Scand. 2019;140(4):274-280.
Zhang, H. J., Zhang, J. R., Mao, C. J., Li, K., Wang, F., Chen, J., & Liu, C. F. (2019). Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms. Acta Neurologica Scandinavica, 140(4), 274-280. https://doi.org/10.1111/ane.13141
Zhang HJ, et al. Relationship Between 25-Hydroxyvitamin D, Bone Density, and Parkinson's Disease Symptoms. Acta Neurol Scand. 2019;140(4):274-280. PubMed PMID: 31389003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between 25-Hydroxyvitamin D, bone density, and Parkinson's disease symptoms. AU - Zhang,Hui-Jun, AU - Zhang,Jin-Ru, AU - Mao,Cheng-Jie, AU - Li,Kai, AU - Wang,Fen, AU - Chen,Jing, AU - Liu,Chun-Feng, Y1 - 2019/08/06/ PY - 2019/03/08/received PY - 2019/06/03/revised PY - 2019/06/13/accepted PY - 2019/8/8/pubmed PY - 2019/12/18/medline PY - 2019/8/8/entrez KW - Parkinson's disease KW - bone mass density KW - non-motor symptoms KW - vitamin D SP - 274 EP - 280 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 140 IS - 4 N2 - OBJECTIVES: Vitamin D deficiency is widespread in patients with Parkinson's disease (PD). Our aim was to determine whether serum vitamin D levels correlated with bone mineral density (BMD) and non-motor symptoms in patients with PD. MATERIALS & METHODS: A consecutive series of 182 patients with PD and 185 healthy controls were included. Serum 25-hydroxyvitamin D (25[OH]D) levels were measured by immunoassay, while BMD of the lumbar spine and femoral neck was measured by dual-energy X-ray absorptiometry. Associations between serum vitamin D levels and clinical data were evaluated using partial correlation analysis. RESULTS: Patients with PD had significantly lower serum 25(OH)D levels relative to healthy controls (49.75 ± 14.11 vs 43.40 ± 16.51, P < 0.001). Furthermore, PD patients with lower vitamin D levels had a significantly higher frequency of falls (P = 0.033) and insomnia (P = 0.015). They also had significantly higher scores for the Pittsburgh Sleep Quality Index (PSQI; P = 0.014), depression (P = 0.020), and anxiety (P = 0.009). Finally, patients with PD also had a significantly lower mean BMD of the lumbar spine (P = 0.011) and femoral neck (P < 0.001). After adjusting for age, sex, and body mass index, vitamin D levels significantly correlated with falls, insomnia, and scores for the PSQI, depression, and anxiety. CONCLUSIONS: In patients with PD, vitamin D levels significantly correlated with falls and some non-motor symptoms. However, no associations were found between BMD and the serum 25(OH)D levels in patients with PD. Thus, vitamin D supplementation is a potential therapeutic for non-motor PD symptoms. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/31389003/Relationship_between_25_Hydroxyvitamin_D_bone_density_and_Parkinson's_disease_symptoms_ L2 - https://doi.org/10.1111/ane.13141 DB - PRIME DP - Unbound Medicine ER -