Tags

Type your tag names separated by a space and hit enter

Does glucagon-like peptide-1 induce diuresis and natriuresis by modulating afferent renal nerve activity?
Am J Physiol Renal Physiol. 2019 10 01; 317(4):F1010-F1021.AJ

Abstract

Glucagon-like peptide-1 (GLP-1), an incretin hormone, has diuretic and natriuretic effects. The present study was designed to explore the possible underlying mechanisms for the diuretic and natriuretic effects of GLP-1 via renal nerves in rats. Immunohistochemistry revealed that GLP-1 receptors were avidly expressed in the pelvic wall, the wall being adjacent to afferent renal nerves immunoreactive to calcitonin gene-related peptide, which is the dominant neurotransmitter for renal afferents. GLP-1 (3 μM) infused into the left renal pelvis increased ipsilateral afferent renal nerve activity (110.0 ± 15.6% of basal value). Intravenous infusion of GLP-1 (1 µg·kg-1·min-1) for 30 min increased renal sympathetic nerve activity (RSNA). After the distal end of the renal nerve was cut to eliminate the afferent signal, the increase in efferent renal nerve activity during intravenous infusion of GLP-1 was diminished compared with the increase in total RSNA (17.0 ± 9.0% vs. 68.1 ± 20.0% of the basal value). Diuretic and natriuretic responses to intravenous infusion of GLP-1 were enhanced by total renal denervation (T-RDN) with acute surgical cutting of the renal nerves. Selective afferent renal nerve denervation (A-RDN) was performed by bilateral perivascular application of capsaicin on the renal nerves. Similar to T-RDN, A-RDN enhanced diuretic and natriuretic responses to GLP-1. Urine flow and Na+ excretion responses to GLP-1 were not significantly different between T-RDN and A-RDN groups. These results indicate that the diuretic and natriuretic effects of GLP-1 are partly governed via activation of afferent renal nerves by GLP-1 acting on sensory nerve fibers within the pelvis of the kidney.

Authors+Show Affiliations

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, South Dakota.Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, South Dakota.Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31390233

Citation

Katsurada, Kenichi, et al. "Does Glucagon-like Peptide-1 Induce Diuresis and Natriuresis By Modulating Afferent Renal Nerve Activity?" American Journal of Physiology. Renal Physiology, vol. 317, no. 4, 2019, pp. F1010-F1021.
Katsurada K, Nandi SS, Sharma NM, et al. Does glucagon-like peptide-1 induce diuresis and natriuresis by modulating afferent renal nerve activity? Am J Physiol Renal Physiol. 2019;317(4):F1010-F1021.
Katsurada, K., Nandi, S. S., Sharma, N. M., Zheng, H., Liu, X., & Patel, K. P. (2019). Does glucagon-like peptide-1 induce diuresis and natriuresis by modulating afferent renal nerve activity? American Journal of Physiology. Renal Physiology, 317(4), F1010-F1021. https://doi.org/10.1152/ajprenal.00028.2019
Katsurada K, et al. Does Glucagon-like Peptide-1 Induce Diuresis and Natriuresis By Modulating Afferent Renal Nerve Activity. Am J Physiol Renal Physiol. 2019 10 1;317(4):F1010-F1021. PubMed PMID: 31390233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does glucagon-like peptide-1 induce diuresis and natriuresis by modulating afferent renal nerve activity? AU - Katsurada,Kenichi, AU - Nandi,Shyam S, AU - Sharma,Neeru M, AU - Zheng,Hong, AU - Liu,Xuefei, AU - Patel,Kaushik P, Y1 - 2019/08/07/ PY - 2020/10/01/pmc-release PY - 2019/8/8/pubmed PY - 2020/3/31/medline PY - 2019/8/8/entrez KW - glucagon-like peptide-1 KW - hemodynamics KW - renal afferent KW - sodium and water homeostasis KW - sympathetic nerve activity SP - F1010 EP - F1021 JF - American journal of physiology. Renal physiology JO - Am. J. Physiol. Renal Physiol. VL - 317 IS - 4 N2 - Glucagon-like peptide-1 (GLP-1), an incretin hormone, has diuretic and natriuretic effects. The present study was designed to explore the possible underlying mechanisms for the diuretic and natriuretic effects of GLP-1 via renal nerves in rats. Immunohistochemistry revealed that GLP-1 receptors were avidly expressed in the pelvic wall, the wall being adjacent to afferent renal nerves immunoreactive to calcitonin gene-related peptide, which is the dominant neurotransmitter for renal afferents. GLP-1 (3 μM) infused into the left renal pelvis increased ipsilateral afferent renal nerve activity (110.0 ± 15.6% of basal value). Intravenous infusion of GLP-1 (1 µg·kg-1·min-1) for 30 min increased renal sympathetic nerve activity (RSNA). After the distal end of the renal nerve was cut to eliminate the afferent signal, the increase in efferent renal nerve activity during intravenous infusion of GLP-1 was diminished compared with the increase in total RSNA (17.0 ± 9.0% vs. 68.1 ± 20.0% of the basal value). Diuretic and natriuretic responses to intravenous infusion of GLP-1 were enhanced by total renal denervation (T-RDN) with acute surgical cutting of the renal nerves. Selective afferent renal nerve denervation (A-RDN) was performed by bilateral perivascular application of capsaicin on the renal nerves. Similar to T-RDN, A-RDN enhanced diuretic and natriuretic responses to GLP-1. Urine flow and Na+ excretion responses to GLP-1 were not significantly different between T-RDN and A-RDN groups. These results indicate that the diuretic and natriuretic effects of GLP-1 are partly governed via activation of afferent renal nerves by GLP-1 acting on sensory nerve fibers within the pelvis of the kidney. SN - 1522-1466 UR - https://www.unboundmedicine.com/medline/citation/31390233/Does_glucagon_like_peptide_1_induce_diuresis_and_natriuresis_by_modulating_afferent_renal_nerve_activity L2 - http://journals.physiology.org/doi/full/10.1152/ajprenal.00028.2019?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -