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Lipophilic statins inhibit Zika virus production in Vero cells.
Sci Rep 2019; 9(1):11461SR

Abstract

Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family. ZIKV infection has been associated with neurological complications such as microcephaly in newborns and Guillain-Barré syndrome in adults; thus, therapeutic agents are urgently needed. Statins are clinically approved for lowering cholesterol levels to prevent cardiovascular disease but have shown potential as antiviral drugs. In this study, we explored the possibility of utilizing statins as anti-ZIKV drugs. We found that, generally, lipophilic statins (atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, and simvastatin) could reduce ZIKV production in vitro and result in smaller foci of infection. Time-of-drug-addition assay revealed that early treatment with statins is more beneficial than late treatment; however, statins could not completely inhibit the entry stage of ZIKV infection. Furthermore, individual lipophilic statins differed in anti-ZIKV capacity, with fluvastatin being the most efficient at low concentrations. Taken together, this study shows that statins or their derivatives have the potential to be used as anti-ZIKV therapeutic agents.

Authors+Show Affiliations

Department of Pharmacy, Korea University College of Pharmacy, Sejong, 30019, Republic of Korea.Department of Pharmacy, Korea University College of Pharmacy, Sejong, 30019, Republic of Korea.Department of Pharmacy, Korea University College of Pharmacy, Sejong, 30019, Republic of Korea.Department of Pharmacy, Korea University College of Pharmacy, Sejong, 30019, Republic of Korea.Department of Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk, 28160, Republic of Korea. cklee@chungbuk.ac.kr.Department of Pharmacy, Korea University College of Pharmacy, Sejong, 30019, Republic of Korea. jkfrancis@korea.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31391514

Citation

Españo, Erica, et al. "Lipophilic Statins Inhibit Zika Virus Production in Vero Cells." Scientific Reports, vol. 9, no. 1, 2019, p. 11461.
Españo E, Nam JH, Song EJ, et al. Lipophilic statins inhibit Zika virus production in Vero cells. Sci Rep. 2019;9(1):11461.
Españo, E., Nam, J. H., Song, E. J., Song, D., Lee, C. K., & Kim, J. K. (2019). Lipophilic statins inhibit Zika virus production in Vero cells. Scientific Reports, 9(1), p. 11461. doi:10.1038/s41598-019-47956-1.
Españo E, et al. Lipophilic Statins Inhibit Zika Virus Production in Vero Cells. Sci Rep. 2019 Aug 7;9(1):11461. PubMed PMID: 31391514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipophilic statins inhibit Zika virus production in Vero cells. AU - Españo,Erica, AU - Nam,Jeong-Hyun, AU - Song,Eun-Jung, AU - Song,Daesub, AU - Lee,Chong-Kil, AU - Kim,Jeong-Ki, Y1 - 2019/08/07/ PY - 2019/02/10/received PY - 2019/07/25/accepted PY - 2019/8/9/entrez PY - 2019/8/9/pubmed PY - 2019/8/9/medline SP - 11461 EP - 11461 JF - Scientific reports JO - Sci Rep VL - 9 IS - 1 N2 - Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family. ZIKV infection has been associated with neurological complications such as microcephaly in newborns and Guillain-Barré syndrome in adults; thus, therapeutic agents are urgently needed. Statins are clinically approved for lowering cholesterol levels to prevent cardiovascular disease but have shown potential as antiviral drugs. In this study, we explored the possibility of utilizing statins as anti-ZIKV drugs. We found that, generally, lipophilic statins (atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, and simvastatin) could reduce ZIKV production in vitro and result in smaller foci of infection. Time-of-drug-addition assay revealed that early treatment with statins is more beneficial than late treatment; however, statins could not completely inhibit the entry stage of ZIKV infection. Furthermore, individual lipophilic statins differed in anti-ZIKV capacity, with fluvastatin being the most efficient at low concentrations. Taken together, this study shows that statins or their derivatives have the potential to be used as anti-ZIKV therapeutic agents. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/31391514/Lipophilic_statins_inhibit_Zika_virus_production_in_Vero_cells L2 - http://dx.doi.org/10.1038/s41598-019-47956-1 DB - PRIME DP - Unbound Medicine ER -