Tags

Type your tag names separated by a space and hit enter

Microglia: The Neural Cells of Nonneural Origin.
Methods Mol Biol 2019; 2034:3-11MM

Abstract

Microglia are neural cells of nonneural origin; they originate from fetal macrophages that invade neural tube early in embryogenesis and undergo the most idiosyncratic metamorphosis which coverts them into elements of neural circuitry. Microglia appeared early in evolution with neural immune cells being operative in leeches and mollusks. Microglial cells acquire specific morphology characterized by small cell bodies and long motile processes which are packed with receptors sensing both physiological and pathological stimuli. Microglial cells actively sculpture neuronal networks through synaptic stripping and phagocytosis of redundant neurons; microglia also secrete neuroactive factors regulating synaptic transmission. Novel techniques emerging in recent decade allowed an in-depth understanding of physiological and pathophysiological functions of microglia.

Authors+Show Affiliations

Department of Neurophysiology, Institute of Physiology, Eberhard Karls University of Tübingen, Tübingen, Germany. olga.garaschuk@uni-tuebingen.de.Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31392673

Citation

Garaschuk, Olga, and Alexei Verkhratsky. "Microglia: the Neural Cells of Nonneural Origin." Methods in Molecular Biology (Clifton, N.J.), vol. 2034, 2019, pp. 3-11.
Garaschuk O, Verkhratsky A. Microglia: The Neural Cells of Nonneural Origin. Methods Mol Biol. 2019;2034:3-11.
Garaschuk, O., & Verkhratsky, A. (2019). Microglia: The Neural Cells of Nonneural Origin. Methods in Molecular Biology (Clifton, N.J.), 2034, pp. 3-11. doi:10.1007/978-1-4939-9658-2_1.
Garaschuk O, Verkhratsky A. Microglia: the Neural Cells of Nonneural Origin. Methods Mol Biol. 2019;2034:3-11. PubMed PMID: 31392673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microglia: The Neural Cells of Nonneural Origin. AU - Garaschuk,Olga, AU - Verkhratsky,Alexei, PY - 2019/8/9/entrez PY - 2019/8/9/pubmed PY - 2019/8/9/medline KW - CNS invasion KW - Development KW - Evolution KW - Microglia KW - Neurogenesis KW - Signaling pathways KW - Synaptic stripping KW - Synaptogenesis SP - 3 EP - 11 JF - Methods in molecular biology (Clifton, N.J.) JO - Methods Mol. Biol. VL - 2034 N2 - Microglia are neural cells of nonneural origin; they originate from fetal macrophages that invade neural tube early in embryogenesis and undergo the most idiosyncratic metamorphosis which coverts them into elements of neural circuitry. Microglia appeared early in evolution with neural immune cells being operative in leeches and mollusks. Microglial cells acquire specific morphology characterized by small cell bodies and long motile processes which are packed with receptors sensing both physiological and pathological stimuli. Microglial cells actively sculpture neuronal networks through synaptic stripping and phagocytosis of redundant neurons; microglia also secrete neuroactive factors regulating synaptic transmission. Novel techniques emerging in recent decade allowed an in-depth understanding of physiological and pathophysiological functions of microglia. SN - 1940-6029 UR - https://www.unboundmedicine.com/medline/citation/31392673/Microglia:_The_Neural_Cells_of_Nonneural_Origin L2 - https://dx.doi.org/10.1007/978-1-4939-9658-2_1 DB - PRIME DP - Unbound Medicine ER -