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Selenium protection against mercury toxicity on the male reproductive system of Clarias gariepinus.

Abstract

The present study aimed to evaluate the protective role of Selenium (Se) (0.1 ppm) on the male reproductive system of the catfish Clarias gariepinus exposed to sublethal doses of Mercury (Hg) (0.04 and 0.12 ppm) for 30 days. Indicators of seminal and gonadal hormone disruption (testosterone, estradiol and 11 keto testosterone), antioxidants (total antioxidant capacity (TAO), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)), oxidative stress biomarkers (lipid peroxidation (LPO), percentage of DNA fragmentation, carbonylated proteins (CP) and nitric oxide (NO)) and histopathological alterations in testicles of Clarias gariepinus were determined. The exposure to Hg resulted in a high accumulation of residues of this metal in testicular tissues. The results showed a significant decrease in sperm count, activity and motility and in all gonadal hormones in Hg exposed groups. Hg exposure also induced a decline in TAO, SOD, CAT and GPx, whereas LPO, DNA fragmentation, CP and NO significantly increased in testicles of C. gariepinus respect to the control group. Although exposure to Se did not reduce the degree of mercury bioconcentration in the testicles, the sperm quality parameters were recovered. Moreover, TAO levels and GPx activity significantly increased after fish exposure to Se, whereas CP levels decreased. LPO, NO, CAT and SOD were also partially normalized when compared with the groups exposed to only Hg. In conclusion, the results showed that Hg, even in the small doses is capable to induce reproductive toxicity in the male catfish. Se exposure partially restored the values of biochemical parameters and sperm quality in Hg-treated fish suggesting protective effects against Hg reproductive toxicity.

Authors+Show Affiliations

Zoology Department, Faculty of Science, New Valley University, Egypt. Electronic address: Ahmedt1983@scinv.au.edu.eg.Department of Aquaculture, Faculty of Natural Resources and Environment, Behbahan Khatam Alanbia University of Technology, Iran.Research Group on Community Nutrition and Oxidative Stress, Department of Fundamental Biology and Health Sciences, CIBEROBN Fisiopatología de la Obesidad la Nutrición, University of Balearic Islands, 07122 Palma de Mallorca, Spain. Electronic address: antoni.sureda@uib.es.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31394254

Citation

Ibrahim, Ahmed Th A., et al. "Selenium Protection Against Mercury Toxicity On the Male Reproductive System of Clarias Gariepinus." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 225, 2019, p. 108583.
Ibrahim ATA, Banaee M, Sureda A. Selenium protection against mercury toxicity on the male reproductive system of Clarias gariepinus. Comp Biochem Physiol C Toxicol Pharmacol. 2019;225:108583.
Ibrahim, A. T. A., Banaee, M., & Sureda, A. (2019). Selenium protection against mercury toxicity on the male reproductive system of Clarias gariepinus. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 225, 108583. https://doi.org/10.1016/j.cbpc.2019.108583
Ibrahim ATA, Banaee M, Sureda A. Selenium Protection Against Mercury Toxicity On the Male Reproductive System of Clarias Gariepinus. Comp Biochem Physiol C Toxicol Pharmacol. 2019;225:108583. PubMed PMID: 31394254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium protection against mercury toxicity on the male reproductive system of Clarias gariepinus. AU - Ibrahim,Ahmed Th A, AU - Banaee,Mahdi, AU - Sureda,Antoni, Y1 - 2019/08/05/ PY - 2019/06/18/received PY - 2019/07/24/revised PY - 2019/08/02/accepted PY - 2019/8/9/pubmed PY - 2020/2/23/medline PY - 2019/8/9/entrez KW - Antioxidant KW - Histopathology KW - Hormones KW - Mercury KW - Selenium KW - Sperm KW - Testes SP - 108583 EP - 108583 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 225 N2 - The present study aimed to evaluate the protective role of Selenium (Se) (0.1 ppm) on the male reproductive system of the catfish Clarias gariepinus exposed to sublethal doses of Mercury (Hg) (0.04 and 0.12 ppm) for 30 days. Indicators of seminal and gonadal hormone disruption (testosterone, estradiol and 11 keto testosterone), antioxidants (total antioxidant capacity (TAO), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)), oxidative stress biomarkers (lipid peroxidation (LPO), percentage of DNA fragmentation, carbonylated proteins (CP) and nitric oxide (NO)) and histopathological alterations in testicles of Clarias gariepinus were determined. The exposure to Hg resulted in a high accumulation of residues of this metal in testicular tissues. The results showed a significant decrease in sperm count, activity and motility and in all gonadal hormones in Hg exposed groups. Hg exposure also induced a decline in TAO, SOD, CAT and GPx, whereas LPO, DNA fragmentation, CP and NO significantly increased in testicles of C. gariepinus respect to the control group. Although exposure to Se did not reduce the degree of mercury bioconcentration in the testicles, the sperm quality parameters were recovered. Moreover, TAO levels and GPx activity significantly increased after fish exposure to Se, whereas CP levels decreased. LPO, NO, CAT and SOD were also partially normalized when compared with the groups exposed to only Hg. In conclusion, the results showed that Hg, even in the small doses is capable to induce reproductive toxicity in the male catfish. Se exposure partially restored the values of biochemical parameters and sperm quality in Hg-treated fish suggesting protective effects against Hg reproductive toxicity. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/31394254/Selenium_protection_against_mercury_toxicity_on_the_male_reproductive_system_of_Clarias_gariepinus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(19)30299-6 DB - PRIME DP - Unbound Medicine ER -