Tags

Type your tag names separated by a space and hit enter

Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices.
Molecules 2019; 24(16)M

Abstract

Paper-based microfluidic devices have advanced significantly in recent years as they are affordable, automated with capillary action, portable, and biodegradable diagnostic platforms for a variety of health, environmental, and food quality applications. In terms of commercialization, however, paper-based microfluidics still have to overcome significant challenges to become an authentic point-of-care testing format with the advanced capabilities of analyte purification, multiplex analysis, quantification, and detection with high sensitivity and selectivity. Moreover, fluid flow manipulation for multistep integration, which involves valving and flow velocity control, is also a critical parameter to achieve high-performance devices. Considering these limitations, the aim of this review is to (i) comprehensively analyze the fabrication techniques of microfluidic paper-based analytical devices, (ii) provide a theoretical background and various methods for fluid flow manipulation, and iii) highlight the recent detection techniques developed for various applications, including their advantages and disadvantages.

Authors+Show Affiliations

School of Mechanical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Korea.Faculty of Mechanical Engineering, Ghulam Ishaq Khan Institute of Engineering Sciences and Technology, Topi 23640, Pakistan. lee.jinkee@skku.edu.School of Mechanical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Korea. ali.turab@giki.edu.pk. Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Korea. ali.turab@giki.edu.pk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31394856

Citation

Lim, Hosub, et al. "Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices." Molecules (Basel, Switzerland), vol. 24, no. 16, 2019.
Lim H, Jafry AT, Lee J. Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices. Molecules. 2019;24(16).
Lim, H., Jafry, A. T., & Lee, J. (2019). Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices. Molecules (Basel, Switzerland), 24(16), doi:10.3390/molecules24162869.
Lim H, Jafry AT, Lee J. Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices. Molecules. 2019 Aug 7;24(16) PubMed PMID: 31394856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fabrication, Flow Control, and Applications of Microfluidic Paper-Based Analytical Devices. AU - Lim,Hosub, AU - Jafry,Ali Turab, AU - Lee,Jinkee, Y1 - 2019/08/07/ PY - 2019/07/20/received PY - 2019/07/31/revised PY - 2019/08/01/accepted PY - 2019/8/10/entrez PY - 2019/8/10/pubmed PY - 2019/8/10/medline KW - 2D µPADs KW - 3D µPADs KW - fabrication KW - microfluidics KW - paper-based analytical device KW - µPAD JF - Molecules (Basel, Switzerland) JO - Molecules VL - 24 IS - 16 N2 - Paper-based microfluidic devices have advanced significantly in recent years as they are affordable, automated with capillary action, portable, and biodegradable diagnostic platforms for a variety of health, environmental, and food quality applications. In terms of commercialization, however, paper-based microfluidics still have to overcome significant challenges to become an authentic point-of-care testing format with the advanced capabilities of analyte purification, multiplex analysis, quantification, and detection with high sensitivity and selectivity. Moreover, fluid flow manipulation for multistep integration, which involves valving and flow velocity control, is also a critical parameter to achieve high-performance devices. Considering these limitations, the aim of this review is to (i) comprehensively analyze the fabrication techniques of microfluidic paper-based analytical devices, (ii) provide a theoretical background and various methods for fluid flow manipulation, and iii) highlight the recent detection techniques developed for various applications, including their advantages and disadvantages. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/31394856/Fabrication,_Flow_Control,_and_Applications_of_Microfluidic_Paper-Based_Analytical_Devices L2 - http://www.mdpi.com/resolver?pii=molecules24162869 DB - PRIME DP - Unbound Medicine ER -
Unbound Prime app for iOS iPhone iPadUnbound PubMed app for AndroidAlso Available:
Unbound MEDLINE
Unbound PubMed app for WindowsUnbound PubMed app for MAC OSX Yosemite Macbook Air pro