Abstract
The 2018 National Guideline for Tuberculosis Control, which was published by the Korea Centers for Diseases Prevention and Control (KCDC), mandates conducting an epidemiological survey among close contacts of active tuberculosis patients at public institutions such as schools. In the procedure for these surveys, the tuberculin skin test (TST) is mandated as the screening test for latent tuberculosis infection in elementary school students. However, several guidelines recommend using the interferon-gamma releasing assay (IGRA) for contacts aged over 5 years with a Bacillus Calmette-Guérin vaccination history. The main reason for this is that IGRA has a higher specificity and lower false positive rate than TST. In addition, IGRA requires only a single visit to draw blood and the results are available within 24 hours. These advantages could promote cooperation from both parents and students in conducting these surveys. Thus, these findings regarding the benefits of IGRA for surveys of close contacts at elementary schools should be incorporated into the KCDC guideline.
TY - JOUR
T1 - Proposal to Revise the Screening Test for Latent Tuberculosis Infection in Close Contacts at Elementary Schools in Korea.
A1 - Bae,Jong-Myon,
Y1 - 2019/05/08/
PY - 2019/02/24/received
PY - 2019/05/08/accepted
PY - 2019/8/10/entrez
PY - 2019/8/10/pubmed
PY - 2019/8/10/medline
KW - Interferon-gamma release tests
KW - Latent tuberculosis
KW - Mycobacterium tuberculosis
KW - Practice guideline
KW - Tuberculin test
SP - 272
EP - 275
JF - Journal of preventive medicine and public health = Yebang Uihakhoe chi
JO - J Prev Med Public Health
VL - 52
IS - 4
N2 - The 2018 National Guideline for Tuberculosis Control, which was published by the Korea Centers for Diseases Prevention and Control (KCDC), mandates conducting an epidemiological survey among close contacts of active tuberculosis patients at public institutions such as schools. In the procedure for these surveys, the tuberculin skin test (TST) is mandated as the screening test for latent tuberculosis infection in elementary school students. However, several guidelines recommend using the interferon-gamma releasing assay (IGRA) for contacts aged over 5 years with a Bacillus Calmette-Guérin vaccination history. The main reason for this is that IGRA has a higher specificity and lower false positive rate than TST. In addition, IGRA requires only a single visit to draw blood and the results are available within 24 hours. These advantages could promote cooperation from both parents and students in conducting these surveys. Thus, these findings regarding the benefits of IGRA for surveys of close contacts at elementary schools should be incorporated into the KCDC guideline.
SN - 2233-4521
UR - https://www.unboundmedicine.com/medline/citation/31396382/Proposal_to_Revise_the_Screening_Test_for_Latent_Tuberculosis_Infection_in_Close_Contacts_at_Elementary_Schools_in_Korea_
DB - PRIME
DP - Unbound Medicine
ER -