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[Features of the Structure and Expression of NPM and NCL Genes in Cutaneous Melanoma].
Mol Biol (Mosk) 2019 Jul-Aug; 53(4):663-673MB

Abstract

Malignant cutaneous melanoma (CM) is an extremely aggressive cancer characterized by a high level of metastatic activity and unfavorable prognosis due to a high incidence of relapses, as well as resistance to standard chemotherapy. Cutaneous melanoma accounts for 80% of deaths from malignant skin tumors. Nucleolin/C23 and nucleophosmin/B23, which constitute altogether ~70% of the nucleolus volume, are promising targets for molecular therapy of melanoma. These proteins perform many important functions in the cell, so disruption of the NCL and/or NPM gene structure and abnormal expression of the C23 and B23 proteins they encode, can lead to unlimited cell proliferation and progression of a tumor. Therefore, investigation of the structure and expression of these genes is a topical problem, which is important for understanding the mechanisms of CM carcinogenesis and for the development of new therapeutic approaches. This paper describes new NCL and NPM polymorphisms, as well as the levels of C23 and B23 expression in normal tissues, CM and mucosal melanoma.

Authors+Show Affiliations

Blokhin Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, 115478 Russia.Blokhin Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, 115478 Russia. LAN21@yandex.ru.

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

31397440

Citation

Ponkratova, D A., and A A. Lushnikova. "[Features of the Structure and Expression of NPM and NCL Genes in Cutaneous Melanoma]." Molekuliarnaia Biologiia, vol. 53, no. 4, 2019, pp. 663-673.
Ponkratova DA, Lushnikova AA. [Features of the Structure and Expression of NPM and NCL Genes in Cutaneous Melanoma]. Mol Biol (Mosk). 2019;53(4):663-673.
Ponkratova, D. A., & Lushnikova, A. A. (2019). [Features of the Structure and Expression of NPM and NCL Genes in Cutaneous Melanoma]. Molekuliarnaia Biologiia, 53(4), pp. 663-673. doi:10.1134/S0026898419040098.
Ponkratova DA, Lushnikova AA. [Features of the Structure and Expression of NPM and NCL Genes in Cutaneous Melanoma]. Mol Biol (Mosk). 2019;53(4):663-673. PubMed PMID: 31397440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Features of the Structure and Expression of NPM and NCL Genes in Cutaneous Melanoma]. AU - Ponkratova,D A, AU - Lushnikova,A A, PY - 2019/02/12/received PY - 2019/03/07/accepted PY - 2019/8/10/entrez KW - B23 KW - C23 KW - NCL KW - NPM KW - carcinogenesis KW - cutaneous melanoma KW - gene expression KW - gene polymorphism KW - mucosal melanoma KW - nucleolin KW - nucleophosmin SP - 663 EP - 673 JF - Molekuliarnaia biologiia JO - Mol. Biol. (Mosk.) VL - 53 IS - 4 N2 - Malignant cutaneous melanoma (CM) is an extremely aggressive cancer characterized by a high level of metastatic activity and unfavorable prognosis due to a high incidence of relapses, as well as resistance to standard chemotherapy. Cutaneous melanoma accounts for 80% of deaths from malignant skin tumors. Nucleolin/C23 and nucleophosmin/B23, which constitute altogether ~70% of the nucleolus volume, are promising targets for molecular therapy of melanoma. These proteins perform many important functions in the cell, so disruption of the NCL and/or NPM gene structure and abnormal expression of the C23 and B23 proteins they encode, can lead to unlimited cell proliferation and progression of a tumor. Therefore, investigation of the structure and expression of these genes is a topical problem, which is important for understanding the mechanisms of CM carcinogenesis and for the development of new therapeutic approaches. This paper describes new NCL and NPM polymorphisms, as well as the levels of C23 and B23 expression in normal tissues, CM and mucosal melanoma. SN - 0026-8984 UR - https://www.unboundmedicine.com/medline/citation/31397440/[Features_of_the_Structure_and_Expression_of_NPM_and_NCL_Genes_in_Cutaneous_Melanoma] L2 - http://molecbio.ru/?view=article&id=7919 DB - PRIME DP - Unbound Medicine ER -