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Radiographic patterns of muscle involvement in the idiopathic inflammatory myopathies.
Muscle Nerve. 2019 11; 60(5):549-557.MN

Abstract

INTRODUCTION

This study assesses the burden, distribution, and evolution of muscle inflammation and damage on MRI among subtypes of idiopathic inflammatory myopathy (IIM).

METHODS

Musculoskeletal MRIs performed in 66 patients with IIM and 10 patients with non-IIM between 2009 and 2016 were retrospectively graded for muscle edema, fatty replacement (FR), and atrophy.

RESULTS

Immune-mediated necrotizing myopathy (IMNM) patients had severe and extensive lower limb muscle edema, FR, and atrophy. The pelvic muscles and adductors were significantly more affected than in patients with dermatomyositis and polymyositis. Inclusion body myositis (IBM) was characterized by marked anterior thigh involvement, which stabilized or progressed at follow-up imaging. Atrophy and FR grades improved over time in some non-IBM IIM patients.

DISCUSSION

Patients with IMNM and IBM have characteristic patterns of muscle MRI abnormalities that may allow them to be differentiated radiologically from other IIM subtypes. Muscle damage in non-IBM IIM may be reversible.

Authors+Show Affiliations

Rheumatology Department, Royal Adelaide Hospital, Adelaide, South Australia, Australia.Radiology Department, Royal Adelaide Hospital, Adelaide, South Australia, Australia.Biostatistics and Epidemiology, University of South Australia, Adelaide, South Australia, Australia.Radiology Department, Royal Adelaide Hospital, Adelaide, South Australia, Australia.Rheumatology Department, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31397909

Citation

Day, Jessica A., et al. "Radiographic Patterns of Muscle Involvement in the Idiopathic Inflammatory Myopathies." Muscle & Nerve, vol. 60, no. 5, 2019, pp. 549-557.
Day JA, Bajic N, Gentili S, et al. Radiographic patterns of muscle involvement in the idiopathic inflammatory myopathies. Muscle Nerve. 2019;60(5):549-557.
Day, J. A., Bajic, N., Gentili, S., Patel, S., & Limaye, V. (2019). Radiographic patterns of muscle involvement in the idiopathic inflammatory myopathies. Muscle & Nerve, 60(5), 549-557. https://doi.org/10.1002/mus.26660
Day JA, et al. Radiographic Patterns of Muscle Involvement in the Idiopathic Inflammatory Myopathies. Muscle Nerve. 2019;60(5):549-557. PubMed PMID: 31397909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radiographic patterns of muscle involvement in the idiopathic inflammatory myopathies. AU - Day,Jessica A, AU - Bajic,Nicholas, AU - Gentili,Sheridan, AU - Patel,Sandy, AU - Limaye,Vidya, Y1 - 2019/08/20/ PY - 2018/12/04/received PY - 2019/07/28/revised PY - 2019/08/06/accepted PY - 2019/8/10/pubmed PY - 2020/1/14/medline PY - 2019/8/10/entrez KW - MRI KW - idiopathic inflammatory myopathy KW - immune mediated necrotizing myopathy KW - inclusion body myositis KW - magnetic resonance imaging KW - myositis KW - necrotizing autoimmune myopathy SP - 549 EP - 557 JF - Muscle & nerve JO - Muscle Nerve VL - 60 IS - 5 N2 - INTRODUCTION: This study assesses the burden, distribution, and evolution of muscle inflammation and damage on MRI among subtypes of idiopathic inflammatory myopathy (IIM). METHODS: Musculoskeletal MRIs performed in 66 patients with IIM and 10 patients with non-IIM between 2009 and 2016 were retrospectively graded for muscle edema, fatty replacement (FR), and atrophy. RESULTS: Immune-mediated necrotizing myopathy (IMNM) patients had severe and extensive lower limb muscle edema, FR, and atrophy. The pelvic muscles and adductors were significantly more affected than in patients with dermatomyositis and polymyositis. Inclusion body myositis (IBM) was characterized by marked anterior thigh involvement, which stabilized or progressed at follow-up imaging. Atrophy and FR grades improved over time in some non-IBM IIM patients. DISCUSSION: Patients with IMNM and IBM have characteristic patterns of muscle MRI abnormalities that may allow them to be differentiated radiologically from other IIM subtypes. Muscle damage in non-IBM IIM may be reversible. SN - 1097-4598 UR - https://www.unboundmedicine.com/medline/citation/31397909/Radiographic_patterns_of_muscle_involvement_in_the_idiopathic_inflammatory_myopathies L2 - https://doi.org/10.1002/mus.26660 DB - PRIME DP - Unbound Medicine ER -