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Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome.
Alzheimers Dement 2019; 15(9):1218-1228AD

Abstract

INTRODUCTION

The corticobasal syndrome (CBS) is associated with several neuropathologic disorders, including corticobasal degeneration and Alzheimer's disease (AD).

METHOD

In this report, we studied 43 AD patients with CBS (AD-CBS) and compared them with 42 AD patients with typical amnestic syndrome (AD-AS), as well as 15 cases of corticobasal degeneration and CBS pathology.

RESULTS

Unlike AD-AS, AD-CBS had prominent motor problems, including limb apraxia (90%), myoclonus (81%), and gait disorders (70%). Alien limb phenomenon was reported in 26% and cortical sensory loss in 14%. Language problems were also more frequent in AD-CBS, and memory impairment was less frequent. AD-CBS had more tau pathology in perirolandic cortices but less in superior temporal cortex than AD-AS. In addition, AD-CBS had greater neuronal loss in the substantia nigra.

DISCUSSION

AD-CBS is a clinicopathological subtype of AD with an atypical distribution of Alzheimer-type tau pathology. Greater neuronal loss in the substantia nigra may contribute to Parkinsonism which is not a feature of typical AD.

Authors+Show Affiliations

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.Department of Neurology, Mayo Clinic, Rochester, MN, USA.Department of Neurology, University of California San Diego, La Jolla, CA, USA.Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.Mount Sinai Medical Center, Miami Beach, FL, USA.Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address: dickson.dennis@mayo.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31399334

Citation

Sakae, Nobutaka, et al. "Clinicopathologic Subtype of Alzheimer's Disease Presenting as Corticobasal Syndrome." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 15, no. 9, 2019, pp. 1218-1228.
Sakae N, Josephs KA, Litvan I, et al. Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome. Alzheimers Dement. 2019;15(9):1218-1228.
Sakae, N., Josephs, K. A., Litvan, I., Murray, M. E., Duara, R., Uitti, R. J., ... Dickson, D. W. (2019). Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 15(9), pp. 1218-1228. doi:10.1016/j.jalz.2019.04.011.
Sakae N, et al. Clinicopathologic Subtype of Alzheimer's Disease Presenting as Corticobasal Syndrome. Alzheimers Dement. 2019;15(9):1218-1228. PubMed PMID: 31399334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome. AU - Sakae,Nobutaka, AU - Josephs,Keith A, AU - Litvan,Irene, AU - Murray,Melissa E, AU - Duara,Ranjan, AU - Uitti,Ryan J, AU - Wszolek,Zbigniew K, AU - van Gerpen,Jay, AU - Graff-Radford,Neil R, AU - Dickson,Dennis W, Y1 - 2019/08/06/ PY - 2019/02/05/received PY - 2019/03/26/revised PY - 2019/04/03/accepted PY - 2019/8/11/pubmed PY - 2019/8/11/medline PY - 2019/8/11/entrez KW - Alzheimer's disease KW - Corticobasal syndrome KW - Neurodegeneration KW - Neuropathology KW - Tau SP - 1218 EP - 1228 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 15 IS - 9 N2 - INTRODUCTION: The corticobasal syndrome (CBS) is associated with several neuropathologic disorders, including corticobasal degeneration and Alzheimer's disease (AD). METHOD: In this report, we studied 43 AD patients with CBS (AD-CBS) and compared them with 42 AD patients with typical amnestic syndrome (AD-AS), as well as 15 cases of corticobasal degeneration and CBS pathology. RESULTS: Unlike AD-AS, AD-CBS had prominent motor problems, including limb apraxia (90%), myoclonus (81%), and gait disorders (70%). Alien limb phenomenon was reported in 26% and cortical sensory loss in 14%. Language problems were also more frequent in AD-CBS, and memory impairment was less frequent. AD-CBS had more tau pathology in perirolandic cortices but less in superior temporal cortex than AD-AS. In addition, AD-CBS had greater neuronal loss in the substantia nigra. DISCUSSION: AD-CBS is a clinicopathological subtype of AD with an atypical distribution of Alzheimer-type tau pathology. Greater neuronal loss in the substantia nigra may contribute to Parkinsonism which is not a feature of typical AD. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/31399334/Clinicopathologic_subtype_of_Alzheimer's_disease_presenting_as_corticobasal_syndrome L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(19)30115-3 DB - PRIME DP - Unbound Medicine ER -