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Abnormal anisotropic diffusion properties in pediatric myelomeningocele patients treated with fetal surgery: an initial DTI study.
Childs Nerv Syst. 2020 Apr; 36(4):827-833.CN

Abstract

PURPOSE

To investigate white matter microstructural abnormality based on diffusion tensor imaging (DTI) in pediatric patients with fetal repair for myelomeningocele (MMC).

METHODS

This was a retrospective analysis of DTI data from 8 pediatric patients with prenatal MMC repair (age range 1.64-33.70 months; sex 3F/5M) and 8 age-matched controls (age 2.24-31.20 months; sex 5F/2M). All participants were scanned on 1.5T GE Signa MR scanner (GE Healthcare, Milwaukee, WI) with the same sequence specifications. Two DTI measures, including fractional anisotropy (FA) and mean diffusivity (MD), were calculated from the genu of corpus callosum (gCC) and the posterior limb of internal capsule (PLIC). DTI values and fronto-occipital horn ratio (FOHR) were tested for group difference based on two-tailed paired t test.

RESULTS

The ventricle size based on FOHR in patients with prenatal MMC repair was significantly larger than that in the age-matched control group (p < 0.001). Statistically significant group difference in DTI (lower FA and higher MD in patient group) was found in gCC (p = 0.007 and 0.003, respectively). A trend level increase in MD was also found (p = 0.065) in PLIC in patients when compared with the age-matched controls.

CONCLUSION

Our data showed white matter abnormality based on DTI in pediatric patient with fetal repair for MMC. The sensitivity of DTI in detecting white matter abnormality, as shown in the present study, may help to serve as an imaging biomarker for assessing hydrocephalus and improve and optimize decision making for the treatment of hydrocephalus in this patient population.

Authors+Show Affiliations

Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. University of Cincinnati College of Medicine, Cincinnati, OH, USA.Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. University of Cincinnati College of Medicine, Cincinnati, OH, USA.University of Cincinnati College of Medicine, Cincinnati, OH, USA. Division of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.Specialty Pediatric Center, Children's Hospital & Medical Center, Omaha, NE, USA.University of Cincinnati College of Medicine, Cincinnati, OH, USA. Weihong.Yuan@cchmc.org. Pediatric Neuroimaging Research Consortium, Division of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 5033, Cincinnati, OH, 45229, USA. Weihong.Yuan@cchmc.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31399765

Citation

Mangano, Francesco T., et al. "Abnormal Anisotropic Diffusion Properties in Pediatric Myelomeningocele Patients Treated With Fetal Surgery: an Initial DTI Study." Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery, vol. 36, no. 4, 2020, pp. 827-833.
Mangano FT, Stevenson CB, Nagaraj U, et al. Abnormal anisotropic diffusion properties in pediatric myelomeningocele patients treated with fetal surgery: an initial DTI study. Childs Nerv Syst. 2020;36(4):827-833.
Mangano, F. T., Stevenson, C. B., Nagaraj, U., Conley, A., & Yuan, W. (2020). Abnormal anisotropic diffusion properties in pediatric myelomeningocele patients treated with fetal surgery: an initial DTI study. Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery, 36(4), 827-833. https://doi.org/10.1007/s00381-019-04339-1
Mangano FT, et al. Abnormal Anisotropic Diffusion Properties in Pediatric Myelomeningocele Patients Treated With Fetal Surgery: an Initial DTI Study. Childs Nerv Syst. 2020;36(4):827-833. PubMed PMID: 31399765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal anisotropic diffusion properties in pediatric myelomeningocele patients treated with fetal surgery: an initial DTI study. AU - Mangano,Francesco T, AU - Stevenson,Charles B, AU - Nagaraj,Usha, AU - Conley,Adam, AU - Yuan,Weihong, Y1 - 2019/08/09/ PY - 2019/05/13/received PY - 2019/08/01/accepted PY - 2019/8/11/pubmed PY - 2019/8/11/medline PY - 2019/8/11/entrez KW - DTI KW - Fetal repair KW - Myelomeningocele KW - White matter injury SP - 827 EP - 833 JF - Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery JO - Childs Nerv Syst VL - 36 IS - 4 N2 - PURPOSE: To investigate white matter microstructural abnormality based on diffusion tensor imaging (DTI) in pediatric patients with fetal repair for myelomeningocele (MMC). METHODS: This was a retrospective analysis of DTI data from 8 pediatric patients with prenatal MMC repair (age range 1.64-33.70 months; sex 3F/5M) and 8 age-matched controls (age 2.24-31.20 months; sex 5F/2M). All participants were scanned on 1.5T GE Signa MR scanner (GE Healthcare, Milwaukee, WI) with the same sequence specifications. Two DTI measures, including fractional anisotropy (FA) and mean diffusivity (MD), were calculated from the genu of corpus callosum (gCC) and the posterior limb of internal capsule (PLIC). DTI values and fronto-occipital horn ratio (FOHR) were tested for group difference based on two-tailed paired t test. RESULTS: The ventricle size based on FOHR in patients with prenatal MMC repair was significantly larger than that in the age-matched control group (p < 0.001). Statistically significant group difference in DTI (lower FA and higher MD in patient group) was found in gCC (p = 0.007 and 0.003, respectively). A trend level increase in MD was also found (p = 0.065) in PLIC in patients when compared with the age-matched controls. CONCLUSION: Our data showed white matter abnormality based on DTI in pediatric patient with fetal repair for MMC. The sensitivity of DTI in detecting white matter abnormality, as shown in the present study, may help to serve as an imaging biomarker for assessing hydrocephalus and improve and optimize decision making for the treatment of hydrocephalus in this patient population. SN - 1433-0350 UR - https://www.unboundmedicine.com/medline/citation/31399765/Abnormal_anisotropic_diffusion_properties_in_pediatric_myelomeningocele_patients_treated_with_fetal_surgery:_an_initial_DTI_study_ L2 - https://doi.org/10.1007/s00381-019-04339-1 DB - PRIME DP - Unbound Medicine ER -
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