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Temperature-dependent viscosity dominated transport control through AQP1 water channel.
J Theor Biol. 2019 11 07; 480:92-98.JT

Abstract

We give a supplementary explanation for previous results about the exclusion of proton as well as hydronium (ion) transport through aquaporins (AQP1) via verified transition state theory by calculating the temperature-dependent viscosity for proton or hydronium (ion) transport through AQP1. We will demonstrate the temperature-dependent viscosity dominated transport control in AQP1 via the selected activation energy as well as the activation volume considering the presumed wavy-roughness along the sub-nano domains. Our numerical results show that once proton or hydronium (ion) transport through AQP1 at room temperature behaves like a molecular fluid with a relatively high viscosity, such as pitch, then proton or hydronium (ion) transport through AQP1 will be blocked (like a solid). Otherwise, proton or hydronium (ion) transport through AQP1 at room temperature manifests like a molecular fluid with a correspondingly lower viscosity, such as water (H2O), and then exclusion of proton or hydronium (ion) through AQP1 will not occur. We also demonstrate possible size effect in blocking proton or hydronium (ion) transport through AQP1. Our predicted results are new and novel as there are no temperature-dependent viscosity measurements relevant to AQP1 yet.

Authors+Show Affiliations

Transfer Centre, 2/F, 16, Lane 21, Guang-Hui Road, Taipei 116, Taiwan, China; Distribution Centre, Golmud Mansion, 33, Road Yingbin, Golmud 816000, China. Electronic address: kh60chu@qq.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31400345

Citation

Kwang-Hua, Chu W.. "Temperature-dependent Viscosity Dominated Transport Control Through AQP1 Water Channel." Journal of Theoretical Biology, vol. 480, 2019, pp. 92-98.
Kwang-Hua CW. Temperature-dependent viscosity dominated transport control through AQP1 water channel. J Theor Biol. 2019;480:92-98.
Kwang-Hua, C. W. (2019). Temperature-dependent viscosity dominated transport control through AQP1 water channel. Journal of Theoretical Biology, 480, 92-98. https://doi.org/10.1016/j.jtbi.2019.08.006
Kwang-Hua CW. Temperature-dependent Viscosity Dominated Transport Control Through AQP1 Water Channel. J Theor Biol. 2019 11 7;480:92-98. PubMed PMID: 31400345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temperature-dependent viscosity dominated transport control through AQP1 water channel. A1 - Kwang-Hua,Chu W, Y1 - 2019/08/07/ PY - 2019/01/23/received PY - 2019/07/26/revised PY - 2019/08/06/accepted PY - 2019/8/11/pubmed PY - 2019/8/11/medline PY - 2019/8/11/entrez KW - Activation energy KW - Aquaporins KW - Boundary perturbation KW - Size effect SP - 92 EP - 98 JF - Journal of theoretical biology JO - J. Theor. Biol. VL - 480 N2 - We give a supplementary explanation for previous results about the exclusion of proton as well as hydronium (ion) transport through aquaporins (AQP1) via verified transition state theory by calculating the temperature-dependent viscosity for proton or hydronium (ion) transport through AQP1. We will demonstrate the temperature-dependent viscosity dominated transport control in AQP1 via the selected activation energy as well as the activation volume considering the presumed wavy-roughness along the sub-nano domains. Our numerical results show that once proton or hydronium (ion) transport through AQP1 at room temperature behaves like a molecular fluid with a relatively high viscosity, such as pitch, then proton or hydronium (ion) transport through AQP1 will be blocked (like a solid). Otherwise, proton or hydronium (ion) transport through AQP1 at room temperature manifests like a molecular fluid with a correspondingly lower viscosity, such as water (H2O), and then exclusion of proton or hydronium (ion) through AQP1 will not occur. We also demonstrate possible size effect in blocking proton or hydronium (ion) transport through AQP1. Our predicted results are new and novel as there are no temperature-dependent viscosity measurements relevant to AQP1 yet. SN - 1095-8541 UR - https://www.unboundmedicine.com/medline/citation/31400345/Temperature-dependent_viscosity_dominated_transport_control_through_AQP1_water_channel L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5193(19)30318-2 DB - PRIME DP - Unbound Medicine ER -
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