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Retrospective Investigation of Grafted Kidney Function After Reversal of Neuromuscular Blockade Using Neostigmine or Sugammadex.
Transplant Proc 2019; 51(7):2265-2267TP

Abstract

INTRODUCTION

Sugammadex has the steroid-encapsulating effect that reverses neuromuscular block induced by aminosteroid neuromuscular-blocking agents. Sugammadex can interact with other drugs that have the same steroidal structure with rocuronium, such as corticosteroids. Corticosteroids play a crucial role in the immunosuppression of kidney transplantation. The purpose of this study was to determine if there are any differences in grafted kidney function in recipients of kidney transplantation when sugammadex or neostigmine is given to the recipient.

METHODS

The study included 42 recipients of kidney transplant, with complete, readable medical charts and anesthetic records. Fourteen recipients' neuromuscular block was reversed with sugammadex (group S) and 28 recipients' neuromuscular block was reversed with neostigmine (group N). We tested noninferiority for serum creatinine during the preoperative period and 5 days after transplantation. Short-term (28 days) outcomes of kidney transplantations were assessed by the incidence of acute rejection episodes, graft failure, length of stay at hospital, and mortality.

RESULTS

There were no significant differences in demographic characteristics, serum creatinine values, short-term outcomes, and graft survival rates at 28 days' postoperatively between group S and group N (P > .05).

CONCLUSIONS

Our data showed no difference in risk of serious adverse effects on short-term graft functions in patients who underwent kidney transplantation. However, considering the sugammadex-corticosteroids interaction, the immunosuppression and long-term effects on grafted kidney functions, current safety experience is insufficient to support the recommendation of routine sugammadex use in this population. These results need to be confirmed by sufficiently powered, controlled, pharmacokinetic, and pharmacodynamic studies on larger patient populations.

Authors+Show Affiliations

Anesthesiology and Reanimation Clinic, Dr Lütfi Kirdar Training and Research Hospital, Istanbul, Turkey. Electronic address: reyhan.arslantas@gmail.com.Anesthesiology and Reanimation Clinic, Dr Lütfi Kirdar Training and Research Hospital, Istanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31400973

Citation

Arslantas, Reyhan, and Banu Eler Cevik. "Retrospective Investigation of Grafted Kidney Function After Reversal of Neuromuscular Blockade Using Neostigmine or Sugammadex." Transplantation Proceedings, vol. 51, no. 7, 2019, pp. 2265-2267.
Arslantas R, Cevik BE. Retrospective Investigation of Grafted Kidney Function After Reversal of Neuromuscular Blockade Using Neostigmine or Sugammadex. Transplant Proc. 2019;51(7):2265-2267.
Arslantas, R., & Cevik, B. E. (2019). Retrospective Investigation of Grafted Kidney Function After Reversal of Neuromuscular Blockade Using Neostigmine or Sugammadex. Transplantation Proceedings, 51(7), pp. 2265-2267. doi:10.1016/j.transproceed.2019.03.051.
Arslantas R, Cevik BE. Retrospective Investigation of Grafted Kidney Function After Reversal of Neuromuscular Blockade Using Neostigmine or Sugammadex. Transplant Proc. 2019;51(7):2265-2267. PubMed PMID: 31400973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrospective Investigation of Grafted Kidney Function After Reversal of Neuromuscular Blockade Using Neostigmine or Sugammadex. AU - Arslantas,Reyhan, AU - Cevik,Banu Eler, Y1 - 2019/08/07/ PY - 2018/12/16/received PY - 2019/02/17/revised PY - 2019/03/12/accepted PY - 2019/8/12/pubmed PY - 2019/8/12/medline PY - 2019/8/12/entrez SP - 2265 EP - 2267 JF - Transplantation proceedings JO - Transplant. Proc. VL - 51 IS - 7 N2 - INTRODUCTION: Sugammadex has the steroid-encapsulating effect that reverses neuromuscular block induced by aminosteroid neuromuscular-blocking agents. Sugammadex can interact with other drugs that have the same steroidal structure with rocuronium, such as corticosteroids. Corticosteroids play a crucial role in the immunosuppression of kidney transplantation. The purpose of this study was to determine if there are any differences in grafted kidney function in recipients of kidney transplantation when sugammadex or neostigmine is given to the recipient. METHODS: The study included 42 recipients of kidney transplant, with complete, readable medical charts and anesthetic records. Fourteen recipients' neuromuscular block was reversed with sugammadex (group S) and 28 recipients' neuromuscular block was reversed with neostigmine (group N). We tested noninferiority for serum creatinine during the preoperative period and 5 days after transplantation. Short-term (28 days) outcomes of kidney transplantations were assessed by the incidence of acute rejection episodes, graft failure, length of stay at hospital, and mortality. RESULTS: There were no significant differences in demographic characteristics, serum creatinine values, short-term outcomes, and graft survival rates at 28 days' postoperatively between group S and group N (P > .05). CONCLUSIONS: Our data showed no difference in risk of serious adverse effects on short-term graft functions in patients who underwent kidney transplantation. However, considering the sugammadex-corticosteroids interaction, the immunosuppression and long-term effects on grafted kidney functions, current safety experience is insufficient to support the recommendation of routine sugammadex use in this population. These results need to be confirmed by sufficiently powered, controlled, pharmacokinetic, and pharmacodynamic studies on larger patient populations. SN - 1873-2623 UR - https://www.unboundmedicine.com/medline/citation/31400973/Retrospective_Investigation_of_Grafted_Kidney_Function_After_Reversal_of_Neuromuscular_Blockade_Using_Neostigmine_or_Sugammadex L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(18)31766-4 DB - PRIME DP - Unbound Medicine ER -