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Comparison of ABC/2 estimation and a volumetric computerized method for measurement of meningiomas using magnetic resonance imaging.
J Neurooncol 2019; 144(2):275-282JN

Abstract

INTRODUCTION

Measurement of tumor growth rates over time for patients with meningiomas has important prognostic and therapeutic implications. Our objective was to compare two methods of measuring meningioma volume: (1) the simplified ellipsoid (ABC/2) method; and (2) perimetric volume measurements using imaging software modules.

METHODS

Patients with conservatively managed meningiomas for at least 1.5 years were retrospectively identified from the VCU Brain and Spine Tumor Registry over a 10-year period (2005-2015). Tumor volumes were independently measured using the simplified ellipsoid and computerized perimetric methods. Intra class correlations (CC) and Bland-Altman analyses were performed.

RESULTS

A total of 26 patients representing 29 tumors were identified. Across 146 images, there were 24 (16%) images that were non-measurable using standard application commands with the computerized perimetric method. The mean volume obtained using the ABC/2 and computerized perimetric methods were 3.2 ± 3.4 cm3 and 3.4 ± 3.5 cm3, respectively. The mean volume difference was 0.2 cm3 (SE = 0.12; p = 0.10) across measurement methods. The concordance correlation coefficient (CCC) between methods was 0.95 (95% CI 0.91, 0.98).

CONCLUSIONS

There is excellent correlation between the simplified ellipsoid and computerized perimetric methods of volumetric analysis for conservatively managed meningiomas. The simplified ellipsoid method remains an excellent method for meningioma volume assessment and had an advantage over the perimetric method which failed to allow measurement of roughly one in six tumors on imaging.

Authors+Show Affiliations

Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, Sixth Floor, P.O. Box 980631, Richmond, VA, 23219-0631, USA.Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, Sixth Floor, P.O. Box 980631, Richmond, VA, 23219-0631, USA.Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, Sixth Floor, P.O. Box 980631, Richmond, VA, 23219-0631, USA.Department of Biostatistics, Virginia Commonwealth University, 830 East Main Street, Seventh Floor, P.O. Box 980032, Richmond, VA, 23298-0032, USA.Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, Sixth Floor, P.O. Box 980631, Richmond, VA, 23219-0631, USA.Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, Sixth Floor, P.O. Box 980631, Richmond, VA, 23219-0631, USA.Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, Sixth Floor, P.O. Box 980631, Richmond, VA, 23219-0631, USA.Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, Sixth Floor, P.O. Box 980631, Richmond, VA, 23219-0631, USA.Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, Sixth Floor, P.O. Box 980631, Richmond, VA, 23219-0631, USA. wbroaddus@vcu.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31401721

Citation

Opalak, Charles F., et al. "Comparison of ABC/2 Estimation and a Volumetric Computerized Method for Measurement of Meningiomas Using Magnetic Resonance Imaging." Journal of Neuro-oncology, vol. 144, no. 2, 2019, pp. 275-282.
Opalak CF, Parry M, Rock AK, et al. Comparison of ABC/2 estimation and a volumetric computerized method for measurement of meningiomas using magnetic resonance imaging. J Neurooncol. 2019;144(2):275-282.
Opalak, C. F., Parry, M., Rock, A. K., Sima, A. P., Carr, M. T., Chandra, V., ... Broaddus, W. C. (2019). Comparison of ABC/2 estimation and a volumetric computerized method for measurement of meningiomas using magnetic resonance imaging. Journal of Neuro-oncology, 144(2), pp. 275-282. doi:10.1007/s11060-019-03205-z.
Opalak CF, et al. Comparison of ABC/2 Estimation and a Volumetric Computerized Method for Measurement of Meningiomas Using Magnetic Resonance Imaging. J Neurooncol. 2019;144(2):275-282. PubMed PMID: 31401721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of ABC/2 estimation and a volumetric computerized method for measurement of meningiomas using magnetic resonance imaging. AU - Opalak,Charles F, AU - Parry,Matthew, AU - Rock,Andrew K, AU - Sima,Adam P, AU - Carr,Matthew T, AU - Chandra,Vyshak, AU - Workman,Kathryn G, AU - Somasundaram,Aravind, AU - Broaddus,William C, Y1 - 2019/08/10/ PY - 2019/03/09/received PY - 2019/06/04/accepted PY - 2019/8/12/pubmed PY - 2019/8/12/medline PY - 2019/8/12/entrez KW - ABC/2 KW - Comparative studies KW - Magnetic resonance imaging KW - Meningioma KW - Tumor burden KW - Tumor volume SP - 275 EP - 282 JF - Journal of neuro-oncology JO - J. Neurooncol. VL - 144 IS - 2 N2 - INTRODUCTION: Measurement of tumor growth rates over time for patients with meningiomas has important prognostic and therapeutic implications. Our objective was to compare two methods of measuring meningioma volume: (1) the simplified ellipsoid (ABC/2) method; and (2) perimetric volume measurements using imaging software modules. METHODS: Patients with conservatively managed meningiomas for at least 1.5 years were retrospectively identified from the VCU Brain and Spine Tumor Registry over a 10-year period (2005-2015). Tumor volumes were independently measured using the simplified ellipsoid and computerized perimetric methods. Intra class correlations (CC) and Bland-Altman analyses were performed. RESULTS: A total of 26 patients representing 29 tumors were identified. Across 146 images, there were 24 (16%) images that were non-measurable using standard application commands with the computerized perimetric method. The mean volume obtained using the ABC/2 and computerized perimetric methods were 3.2 ± 3.4 cm3 and 3.4 ± 3.5 cm3, respectively. The mean volume difference was 0.2 cm3 (SE = 0.12; p = 0.10) across measurement methods. The concordance correlation coefficient (CCC) between methods was 0.95 (95% CI 0.91, 0.98). CONCLUSIONS: There is excellent correlation between the simplified ellipsoid and computerized perimetric methods of volumetric analysis for conservatively managed meningiomas. The simplified ellipsoid method remains an excellent method for meningioma volume assessment and had an advantage over the perimetric method which failed to allow measurement of roughly one in six tumors on imaging. SN - 1573-7373 UR - https://www.unboundmedicine.com/medline/citation/31401721/Comparison_of_ABC/2_estimation_and_a_volumetric_computerized_method_for_measurement_of_meningiomas_using_magnetic_resonance_imaging L2 - https://doi.org/10.1007/s11060-019-03205-z DB - PRIME DP - Unbound Medicine ER -