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Ultraminiature and Flexible Sensor Based on Interior Corner Flow for Direct Pressure Sensing in Biofluids.
Small 2019; :e1900950S

Abstract

Conventional pressure sensing devices are well developed for either indirect evaluation or internal measuring of fluid pressure over millimeter scale. Whereas, specialized pressure sensors that can directly work in various liquid environments at micrometer scale remain challenging and rarely explored, but are of great importance in many biomedical applications. Here, pressure sensor technology that utilizes capillary action to self-assemble the pressure-sensitive element is introduced. Sophisticated control of capillary flow, tunable sensitivity to liquid pressure in various mediums, and multiple transduction modes are realized in a polymer device, which is also flexible (thickness of 8 µm), ultraminiature (effective volume of 18 × 100 × 580 µm3), and transparent, enabling the sensor to work in some extreme situations, such as in narrow inner spaces (e.g., a microchannel of 220 µm in width and 100 µm in height), or on the surface of small objects (e.g., a 380 µm diameter needle). Potential applications of this sensor include disposables for in vivo and short-term measurements.

Authors+Show Affiliations

National Key Laboratory of Science and Technology on Micro/Nano Fabrication Laboratory, Department of Micro/Nano-electronics, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China. Shanghai NeuroZing Co., Ltd, Shanghai, 201318, P. R. China.National Key Laboratory of Science and Technology on Micro/Nano Fabrication Laboratory, Department of Micro/Nano-electronics, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.National Key Laboratory of Science and Technology on Micro/Nano Fabrication Laboratory, Department of Micro/Nano-electronics, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.National Key Laboratory of Science and Technology on Micro/Nano Fabrication Laboratory, Department of Micro/Nano-electronics, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.National Key Laboratory of Science and Technology on Micro/Nano Fabrication Laboratory, Department of Micro/Nano-electronics, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, 200233, China.Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, 200233, China.National Key Laboratory of Science and Technology on Micro/Nano Fabrication Laboratory, Department of Micro/Nano-electronics, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31402551

Citation

Tang, Longjun, et al. "Ultraminiature and Flexible Sensor Based On Interior Corner Flow for Direct Pressure Sensing in Biofluids." Small (Weinheim an Der Bergstrasse, Germany), 2019, pp. e1900950.
Tang L, Hong W, Wang X, et al. Ultraminiature and Flexible Sensor Based on Interior Corner Flow for Direct Pressure Sensing in Biofluids. Small. 2019.
Tang, L., Hong, W., Wang, X., Sun, W., Yang, B., Wei, M., ... Liu, J. (2019). Ultraminiature and Flexible Sensor Based on Interior Corner Flow for Direct Pressure Sensing in Biofluids. Small (Weinheim an Der Bergstrasse, Germany), pp. e1900950. doi:10.1002/smll.201900950.
Tang L, et al. Ultraminiature and Flexible Sensor Based On Interior Corner Flow for Direct Pressure Sensing in Biofluids. Small. 2019 Aug 12;e1900950. PubMed PMID: 31402551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultraminiature and Flexible Sensor Based on Interior Corner Flow for Direct Pressure Sensing in Biofluids. AU - Tang,Longjun, AU - Hong,Wen, AU - Wang,Xiaolin, AU - Sun,Wenxi, AU - Yang,Bin, AU - Wei,Meng, AU - Pan,Jingwei, AU - Liu,Jingquan, Y1 - 2019/08/12/ PY - 2019/02/21/received PY - 2019/06/01/revised PY - 2019/8/13/entrez KW - biofluids KW - flexible pressure sensor KW - interior corner flow SP - e1900950 EP - e1900950 JF - Small (Weinheim an der Bergstrasse, Germany) JO - Small N2 - Conventional pressure sensing devices are well developed for either indirect evaluation or internal measuring of fluid pressure over millimeter scale. Whereas, specialized pressure sensors that can directly work in various liquid environments at micrometer scale remain challenging and rarely explored, but are of great importance in many biomedical applications. Here, pressure sensor technology that utilizes capillary action to self-assemble the pressure-sensitive element is introduced. Sophisticated control of capillary flow, tunable sensitivity to liquid pressure in various mediums, and multiple transduction modes are realized in a polymer device, which is also flexible (thickness of 8 µm), ultraminiature (effective volume of 18 × 100 × 580 µm3), and transparent, enabling the sensor to work in some extreme situations, such as in narrow inner spaces (e.g., a microchannel of 220 µm in width and 100 µm in height), or on the surface of small objects (e.g., a 380 µm diameter needle). Potential applications of this sensor include disposables for in vivo and short-term measurements. SN - 1613-6829 UR - https://www.unboundmedicine.com/medline/citation/31402551/Ultraminiature_and_Flexible_Sensor_Based_on_Interior_Corner_Flow_for_Direct_Pressure_Sensing_in_Biofluids L2 - https://doi.org/10.1002/smll.201900950 DB - PRIME DP - Unbound Medicine ER -