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The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2.
Med Arch. 2019 Jun; 73(3):163-168.MA

Abstract

INTRODUCTION

Poor glycemic control, assessed by higher glycated hemoglobin (HbA1c) levels, is associated with greater risk of diabetic complications.

AIM

The aim of this study was to assess the association of triglyceride - to - HDL cholesterol (TG/HDL-C) ratio and triglyceride glucose (TyG) index with HbA1c and to evaluate their potential role as predictors of glycemic control in patients with diabetes mellitus type 2 (DM2).

PATIENTS AND METHODS

This cross-sectional study was conducted in Health Center Banovici and included a total of 113 patients with DM2 classified according to their HbA1c values in two groups: DM2 HbA1c <7% - DM2 patients with good glycemic control (n=39) and DM2 HbA1c ≥7% - DM2 patients with poor glycemic control (n=74). Anthropometric, biochemical parameters and blood pressure values were measured, while TG/HDL-C ratio and TyG index were calculated.

RESULTS

TG/HDL-C ratio and TyG index were significantly higher in DM2 HbA1c≥7% compared to DM2 HbA1c<7% group (p=0.003 and p<0.001; respectively). Both TG/HDL-C ratio and TyG index were positively associated with HbA1c levels (Rho=0.29; p=0.002; Rho=0.37; p<0.001; respectively). In linear regression analysis TG/HDL-C ratio and BMI, and also TyG index and BMI were significantly independently associated with HbA1c even after controlling for age, gender, diabetes duration and smoking. When we stratified patients according to BMI values, independent association between TG/HDL-C ratio and HbA1c remained significant only in normal weight subjects (OR 0.21; 95%CI: 0.05-0.37; β=0.65; p=0.017), while independent association between TyG index and HbA1c remained significant only in overweight and obese subjects (OR 0.063; 95%CI: 0.01- 0.12; β=0.24; p =0.027).

CONCLUSION

TG/HDL-C ratio might be a useful predictor of glycemic control in normal weight, and TyG index in overweight and obese patients with DM2.

Links

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Authors+Show Affiliations

Babic N
Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Valjevac A
Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Zaciragic A
Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Avdagic N
Department of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Zukic S
Health Center Banovici, Banovici, Bosnia and Herzegovina.
Hasic S
Department of Medical Biochemistry, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

MeSH

AgedAged, 80 and overBlood GlucoseBody Mass IndexCholesterol, HDLCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansIdeal Body WeightMaleMiddle AgedObesityTriglycerides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31404127

Citation

Babic, Nermina, et al. "The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients With Diabetes Mellitus Type 2." Medical Archives (Sarajevo, Bosnia and Herzegovina), vol. 73, no. 3, 2019, pp. 163-168.
Babic N, Valjevac A, Zaciragic A, et al. The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2. Med Arch. 2019;73(3):163-168.
Babic, N., Valjevac, A., Zaciragic, A., Avdagic, N., Zukic, S., & Hasic, S. (2019). The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2. Medical Archives (Sarajevo, Bosnia and Herzegovina), 73(3), 163-168. https://doi.org/10.5455/medarh.2019.73.163-168
Babic N, et al. The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients With Diabetes Mellitus Type 2. Med Arch. 2019;73(3):163-168. PubMed PMID: 31404127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2. AU - Babic,Nermina, AU - Valjevac,Amina, AU - Zaciragic,Asija, AU - Avdagic,Nesina, AU - Zukic,Sabina, AU - Hasic,Sabaheta, PY - 2019/8/13/entrez PY - 2019/8/14/pubmed PY - 2020/1/29/medline KW - HbA1c KW - TG/HDL-C ratio KW - TyG index KW - glycemic control KW - patients with diabetes mellitus type 2 SP - 163 EP - 168 JF - Medical archives (Sarajevo, Bosnia and Herzegovina) JO - Med Arch VL - 73 IS - 3 N2 - INTRODUCTION: Poor glycemic control, assessed by higher glycated hemoglobin (HbA1c) levels, is associated with greater risk of diabetic complications. AIM: The aim of this study was to assess the association of triglyceride - to - HDL cholesterol (TG/HDL-C) ratio and triglyceride glucose (TyG) index with HbA1c and to evaluate their potential role as predictors of glycemic control in patients with diabetes mellitus type 2 (DM2). PATIENTS AND METHODS: This cross-sectional study was conducted in Health Center Banovici and included a total of 113 patients with DM2 classified according to their HbA1c values in two groups: DM2 HbA1c <7% - DM2 patients with good glycemic control (n=39) and DM2 HbA1c ≥7% - DM2 patients with poor glycemic control (n=74). Anthropometric, biochemical parameters and blood pressure values were measured, while TG/HDL-C ratio and TyG index were calculated. RESULTS: TG/HDL-C ratio and TyG index were significantly higher in DM2 HbA1c≥7% compared to DM2 HbA1c<7% group (p=0.003 and p<0.001; respectively). Both TG/HDL-C ratio and TyG index were positively associated with HbA1c levels (Rho=0.29; p=0.002; Rho=0.37; p<0.001; respectively). In linear regression analysis TG/HDL-C ratio and BMI, and also TyG index and BMI were significantly independently associated with HbA1c even after controlling for age, gender, diabetes duration and smoking. When we stratified patients according to BMI values, independent association between TG/HDL-C ratio and HbA1c remained significant only in normal weight subjects (OR 0.21; 95%CI: 0.05-0.37; β=0.65; p=0.017), while independent association between TyG index and HbA1c remained significant only in overweight and obese subjects (OR 0.063; 95%CI: 0.01- 0.12; β=0.24; p =0.027). CONCLUSION: TG/HDL-C ratio might be a useful predictor of glycemic control in normal weight, and TyG index in overweight and obese patients with DM2. SN - 1986-5961 UR - https://www.unboundmedicine.com/medline/citation/31404127/The_Triglyceride/HDL_Ratio_and_Triglyceride_Glucose_Index_as_Predictors_of_Glycemic_Control_in_Patients_with_Diabetes_Mellitus_Type_2_ DB - PRIME DP - Unbound Medicine ER -