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Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation.
Pediatrics. 2019 09; 144(3)Ped

Abstract

OBJECTIVES

To examine changes in care practices over time by race and ethnicity and whether the decrease in hospital mortality and severe morbidities has benefited infants of minority over infants of white mothers.

METHODS

Infants 22 to 29 weeks' gestation born between January 2006 and December 2017 at a Vermont Oxford Network center in the United States were studied. We examined mortality and morbidity rate differences and 95% confidence intervals for African American and Hispanic versus white infants by birth year. We tested temporal differences in mortality and morbidity rates between white and African American or Hispanic infants using a likelihood ratio test on nested binomial regression models.

RESULTS

Disparities for certain care practices such as antenatal corticosteroids and for some in-hospital outcomes have narrowed over time for minority infants. Compared with white infants, African American infants had a faster decline for mortality, hypothermia, necrotizing enterocolitis, and late-onset sepsis, whereas Hispanic infants had a faster decline for mortality, respiratory distress syndrome, and pneumothorax. Other morbidities showed a constant rate difference between African American and Hispanic versus white infants over time. Despite the improvements, outcomes including hypothermia, mortality, necrotizing enterocolitis, late-onset sepsis, and severe intraventricular hemorrhage remained elevated by the end of the study period, especially among African American infants.

CONCLUSIONS

Racial and ethnic disparities in vital care practices and certain outcomes have decreased. That the quality deficit among minority infants occurred for several care practice measures and potentially modifiable outcomes suggests a critical role for quality improvement initiatives tailored for minority-serving hospitals.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina; nboghoss@mailbox.sc.edu.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina.Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Leonard Davis Institute of Health Economics, Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania.Health Economics Resource Center and Center for Implementation to Innovation, Veterans Affairs Palo Alto Health Care System, Menlo Park, California. Perinatal Epidemiology and Health Outcomes Research Unit, Division of Neonatology, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California.Vermont Oxford Network, Burlington, Vermont. Department of Mathematics and Statistics, University of Vermont, Burlington, Vermont; and. Department of Pediatrics, College of Medicine, University of Vermont, Burlington, Vermont.Vermont Oxford Network, Burlington, Vermont. Department of Pediatrics, College of Medicine, University of Vermont, Burlington, Vermont.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31405887

Citation

Boghossian, Nansi S., et al. "Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation." Pediatrics, vol. 144, no. 3, 2019.
Boghossian NS, Geraci M, Lorch SA, et al. Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation. Pediatrics. 2019;144(3).
Boghossian, N. S., Geraci, M., Lorch, S. A., Phibbs, C. S., Edwards, E. M., & Horbar, J. D. (2019). Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation. Pediatrics, 144(3). https://doi.org/10.1542/peds.2019-1106
Boghossian NS, et al. Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation. Pediatrics. 2019;144(3) PubMed PMID: 31405887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation. AU - Boghossian,Nansi S, AU - Geraci,Marco, AU - Lorch,Scott A, AU - Phibbs,Ciaran S, AU - Edwards,Erika M, AU - Horbar,Jeffrey D, Y1 - 2019/08/12/ PY - 2019/05/15/accepted PY - 2019/8/14/pubmed PY - 2020/1/17/medline PY - 2019/8/14/entrez JF - Pediatrics JO - Pediatrics VL - 144 IS - 3 N2 - OBJECTIVES: To examine changes in care practices over time by race and ethnicity and whether the decrease in hospital mortality and severe morbidities has benefited infants of minority over infants of white mothers. METHODS: Infants 22 to 29 weeks' gestation born between January 2006 and December 2017 at a Vermont Oxford Network center in the United States were studied. We examined mortality and morbidity rate differences and 95% confidence intervals for African American and Hispanic versus white infants by birth year. We tested temporal differences in mortality and morbidity rates between white and African American or Hispanic infants using a likelihood ratio test on nested binomial regression models. RESULTS: Disparities for certain care practices such as antenatal corticosteroids and for some in-hospital outcomes have narrowed over time for minority infants. Compared with white infants, African American infants had a faster decline for mortality, hypothermia, necrotizing enterocolitis, and late-onset sepsis, whereas Hispanic infants had a faster decline for mortality, respiratory distress syndrome, and pneumothorax. Other morbidities showed a constant rate difference between African American and Hispanic versus white infants over time. Despite the improvements, outcomes including hypothermia, mortality, necrotizing enterocolitis, late-onset sepsis, and severe intraventricular hemorrhage remained elevated by the end of the study period, especially among African American infants. CONCLUSIONS: Racial and ethnic disparities in vital care practices and certain outcomes have decreased. That the quality deficit among minority infants occurred for several care practice measures and potentially modifiable outcomes suggests a critical role for quality improvement initiatives tailored for minority-serving hospitals. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/31405887/Racial_and_Ethnic_Differences_Over_Time_in_Outcomes_of_Infants_Born_Less_Than_30_Weeks'_Gestation_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=31405887 DB - PRIME DP - Unbound Medicine ER -