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Minimal difference between fractionated and single-fraction exposure in a murine model of radiation necrosis.
Radiat Oncol 2019; 14(1):144RO

Abstract

PURPOSE

Despite the success of fractionation in clinical practice to spare healthy tissue, it remains common for mouse models used to study the efficacy of radiation therapy to use minimal or no fractionation. The goal of our study was to create a fractionated mouse model of radiation necrosis that we could compare to our single fraction model.

METHODS

Precision X-Ray's X-Rad 320 cabinet irradiator was used to irradiate the cerebrum of mice with four different fractionation schemes, while a 7 T Bruker magnetic resonance imaging (MRI) scanner using T2 and post-contrast T1 imaging was used to track the development of radiation necrosis over the span of six weeks.

RESULTS

All four fractionation schemes with single fraction equivalent doses (SFED) less than 50 Gy for the commonly accepted alpha/beta ratio (α/β) value of 2-3 Gy produced radiation necrosis comparable to what would be achieved with single fraction doses of 80 and 90 Gy. This is surprising when previous work using single fractions of 50 Gy produced no visible radiation necrosis, with the results of this study showing fractionation not sparing brain tissue as much as expected.

CONCLUSION

Further interpretation of these results must take into consideration other studies which have shown a lack of sparing when fractionation has been incorporated, as well as consider factors such as the use of large doses per fraction, the time between fractions, and the limitations of using a murine model to analyze the human condition.

Authors+Show Affiliations

School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Hampton Hall 1263A, West Lafayette, IN, 47907, USA.School of Health Sciences, Purdue University, 550 Stadium Mall Drive, Hampton Hall 1263A, West Lafayette, IN, 47907, USA. cperezto@purdue.edu. Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA. cperezto@purdue.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31409408

Citation

Boria, Andrew J., and Carlos J. Perez-Torres. "Minimal Difference Between Fractionated and Single-fraction Exposure in a Murine Model of Radiation Necrosis." Radiation Oncology (London, England), vol. 14, no. 1, 2019, p. 144.
Boria AJ, Perez-Torres CJ. Minimal difference between fractionated and single-fraction exposure in a murine model of radiation necrosis. Radiat Oncol. 2019;14(1):144.
Boria, A. J., & Perez-Torres, C. J. (2019). Minimal difference between fractionated and single-fraction exposure in a murine model of radiation necrosis. Radiation Oncology (London, England), 14(1), p. 144. doi:10.1186/s13014-019-1356-3.
Boria AJ, Perez-Torres CJ. Minimal Difference Between Fractionated and Single-fraction Exposure in a Murine Model of Radiation Necrosis. Radiat Oncol. 2019 Aug 13;14(1):144. PubMed PMID: 31409408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Minimal difference between fractionated and single-fraction exposure in a murine model of radiation necrosis. AU - Boria,Andrew J, AU - Perez-Torres,Carlos J, Y1 - 2019/08/13/ PY - 2019/03/11/received PY - 2019/08/07/accepted PY - 2019/8/15/entrez PY - 2019/8/15/pubmed PY - 2019/8/15/medline KW - Fractionation KW - MRI KW - Mouse model KW - Radiation biology KW - Radiation necrosis SP - 144 EP - 144 JF - Radiation oncology (London, England) JO - Radiat Oncol VL - 14 IS - 1 N2 - PURPOSE: Despite the success of fractionation in clinical practice to spare healthy tissue, it remains common for mouse models used to study the efficacy of radiation therapy to use minimal or no fractionation. The goal of our study was to create a fractionated mouse model of radiation necrosis that we could compare to our single fraction model. METHODS: Precision X-Ray's X-Rad 320 cabinet irradiator was used to irradiate the cerebrum of mice with four different fractionation schemes, while a 7 T Bruker magnetic resonance imaging (MRI) scanner using T2 and post-contrast T1 imaging was used to track the development of radiation necrosis over the span of six weeks. RESULTS: All four fractionation schemes with single fraction equivalent doses (SFED) less than 50 Gy for the commonly accepted alpha/beta ratio (α/β) value of 2-3 Gy produced radiation necrosis comparable to what would be achieved with single fraction doses of 80 and 90 Gy. This is surprising when previous work using single fractions of 50 Gy produced no visible radiation necrosis, with the results of this study showing fractionation not sparing brain tissue as much as expected. CONCLUSION: Further interpretation of these results must take into consideration other studies which have shown a lack of sparing when fractionation has been incorporated, as well as consider factors such as the use of large doses per fraction, the time between fractions, and the limitations of using a murine model to analyze the human condition. SN - 1748-717X UR - https://www.unboundmedicine.com/medline/citation/31409408/Minimal_difference_between_fractionated_and_single-fraction_exposure_in_a_murine_model_of_radiation_necrosis L2 - https://ro-journal.biomedcentral.com/articles/10.1186/s13014-019-1356-3 DB - PRIME DP - Unbound Medicine ER -