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Endogenous production of n-3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α-linolenic:linoleic ratio in Atlantic salmon (Salmo salar).
Br J Nutr. 2019 11 28; 122(10):1091-1102.BJ

Abstract

Atlantic salmon (Salmo salar) possess enzymes required for the endogenous biosynthesis of n-3 long-chain PUFA (LC-PUFA), EPA and DHA, from α-linolenic acid (ALA). Linoleic acid (LA) competes with ALA for LC-PUFA biosynthesis enzymes leading to the production of n-6 LC-PUFA, including arachidonic acid (ARA). We aimed to quantify the endogenous production of EPA and DHA from ALA in salmon fed from first feeding on diets that contain no EPA and DHA and to determine the influence of dietary LA and ALA:LA ratio on LC-PUFA production. Salmon were fed from first feeding for 22 weeks with three diets formulated with linseed and sunflower oils to provide ALA:LA ratios of approximately 3:1, 1:1 and 1:3. Endogenous production of n-3 LC-PUFA was 5·9, 4·4 and 2·8 mg per g fish and that of n-6 LC-PUFA was 0·2, 0·5 and 1·4 mg per g fish in salmon fed diets with ALA:LA ratios of 3:1, 1:1 and 1:3, respectively. The ratio of n-3:n-6 LC-PUFA production decreased from 27·4 to 2·0, and DHA:EPA ratio increased and EPA:ARA and DHA:ARA ratios decreased, as dietary ALA:LA ratio decreased. In conclusion, with a dietary ALA:LA ratio of 1, salmon fry/parr produced about 28 μg n-3 LC-PUFA per g fish per d, with a DHA:EPA ratio of 3·4. Production of n-3 LC-PUFA exceeded that of n-6 LC-PUFA by almost 9-fold. Reducing the dietary ALA:LA ratio reduced n-3 LC-PUFA production and EPA:ARA and DHA:ARA ratios but increased n-6 LC-PUFA production and DHA:EPA ratio.

Authors+Show Affiliations

Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, Stirling FK9 4LA, Scotland, UK.Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, Stirling FK9 4LA, Scotland, UK.Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, Stirling FK9 4LA, Scotland, UK.Department of Biology, Norwegian University of Science and Technology, Trondheim 7491, Norway.Institute of Marine Research, Matre Research Station, Matredal 5984, Norway.Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, Stirling FK9 4LA, Scotland, UK.Institute of Aquaculture, Faculty of Natural Sciences, University of Stirling, Stirling FK9 4LA, Scotland, UK.

Pub Type(s)

Clinical Trial, Veterinary
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31409428

Citation

Sprague, Matthew, et al. "Endogenous Production of N-3 Long-chain PUFA From First Feeding and the Influence of Dietary Linoleic Acid and the Α-linolenic:linoleic Ratio in Atlantic Salmon (Salmo Salar)." The British Journal of Nutrition, vol. 122, no. 10, 2019, pp. 1091-1102.
Sprague M, Xu G, Betancor MB, et al. Endogenous production of n-3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α-linolenic:linoleic ratio in Atlantic salmon (Salmo salar). Br J Nutr. 2019;122(10):1091-1102.
Sprague, M., Xu, G., Betancor, M. B., Olsen, R. E., Torrissen, O., Glencross, B. D., & Tocher, D. R. (2019). Endogenous production of n-3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α-linolenic:linoleic ratio in Atlantic salmon (Salmo salar). The British Journal of Nutrition, 122(10), 1091-1102. https://doi.org/10.1017/S0007114519001946
Sprague M, et al. Endogenous Production of N-3 Long-chain PUFA From First Feeding and the Influence of Dietary Linoleic Acid and the Α-linolenic:linoleic Ratio in Atlantic Salmon (Salmo Salar). Br J Nutr. 2019 11 28;122(10):1091-1102. PubMed PMID: 31409428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous production of n-3 long-chain PUFA from first feeding and the influence of dietary linoleic acid and the α-linolenic:linoleic ratio in Atlantic salmon (Salmo salar). AU - Sprague,Matthew, AU - Xu,Gong, AU - Betancor,Monica B, AU - Olsen,Rolf E, AU - Torrissen,Ole, AU - Glencross,Brett D, AU - Tocher,Douglas R, Y1 - 2019/08/14/ PY - 2019/8/15/pubmed PY - 2020/6/5/medline PY - 2019/8/15/entrez KW - Arachidonic acid KW - Biosynthesis KW - DHA KW - Desaturation KW - EPA KW - Elongation SP - 1091 EP - 1102 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 122 IS - 10 N2 - Atlantic salmon (Salmo salar) possess enzymes required for the endogenous biosynthesis of n-3 long-chain PUFA (LC-PUFA), EPA and DHA, from α-linolenic acid (ALA). Linoleic acid (LA) competes with ALA for LC-PUFA biosynthesis enzymes leading to the production of n-6 LC-PUFA, including arachidonic acid (ARA). We aimed to quantify the endogenous production of EPA and DHA from ALA in salmon fed from first feeding on diets that contain no EPA and DHA and to determine the influence of dietary LA and ALA:LA ratio on LC-PUFA production. Salmon were fed from first feeding for 22 weeks with three diets formulated with linseed and sunflower oils to provide ALA:LA ratios of approximately 3:1, 1:1 and 1:3. Endogenous production of n-3 LC-PUFA was 5·9, 4·4 and 2·8 mg per g fish and that of n-6 LC-PUFA was 0·2, 0·5 and 1·4 mg per g fish in salmon fed diets with ALA:LA ratios of 3:1, 1:1 and 1:3, respectively. The ratio of n-3:n-6 LC-PUFA production decreased from 27·4 to 2·0, and DHA:EPA ratio increased and EPA:ARA and DHA:ARA ratios decreased, as dietary ALA:LA ratio decreased. In conclusion, with a dietary ALA:LA ratio of 1, salmon fry/parr produced about 28 μg n-3 LC-PUFA per g fish per d, with a DHA:EPA ratio of 3·4. Production of n-3 LC-PUFA exceeded that of n-6 LC-PUFA by almost 9-fold. Reducing the dietary ALA:LA ratio reduced n-3 LC-PUFA production and EPA:ARA and DHA:ARA ratios but increased n-6 LC-PUFA production and DHA:EPA ratio. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/31409428/Endogenous_production_of_n_3_long_chain_PUFA_from_first_feeding_and_the_influence_of_dietary_linoleic_acid_and_the_α_linolenic:linoleic_ratio_in_Atlantic_salmon__Salmo_salar__ L2 - https://www.cambridge.org/core/product/identifier/S0007114519001946/type/journal_article DB - PRIME DP - Unbound Medicine ER -