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Longitudinal changes in axial length in high myopia: a 4-year prospective study.

Abstract

AIM

To determine the longitudinal changes in the axial length (AL) in patients with high myopia without any other ophthalmic disease METHODS: Participants were divided into two groups: a high myopia group (60 eyes) without myopic degeneration, such as chorioretinal atrophy or posterior staphyloma, and a control group (60 eyes). Both groups were further divided into subgroups according to the AL: subgroup 1 (≥27.5 mm), subgroup 2 (26.0-27.5 mm), subgroup 3 (24.5-26.0 mm) and subgroup 4 (<24.5 mm). The ALs were measured five times at 1-year interval using an IOL master, and the AL was fitted with linear mixed models.

RESULTS

In the high myopia group, the AL showed a relatively constant increase at each visit, and they were significantly different with previous measurements at most visits, whereas the control group showed no significant change of AL. Subgroups 1,2 and 3 showed significant changes in AL over time (0.064, 0.032 and 0.012 mm/y, respectively). In univariate analyses, age, best-corrected visual acuity, baseline AL and anterior chamber depth were significantly correlated with changes in the AL in the high myopia group. In multivariate analysis, only baseline AL remained significant (p<0.001).

CONCLUSIONS

Myopic eyes, including moderately myopic eyes, showed a consistent increase in AL over 4 years, and eyes with a longer baseline AL showed a greater increase in AL than eyes with a shorter AL.

Authors+Show Affiliations

Department of Ophthalmology, Chungnam National University Hospital, Daejeon, Korea, Republic of. Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea, Republic of.Department of Ophthalmology, Chungnam National University Hospital, Daejeon, Korea, Republic of.Department of Ophthalmology, Chungnam National University Hospital, Daejeon, Korea, Republic of.Department of Ophthalmology, Chungnam National University Hospital, Daejeon, Korea, Republic of kimjy@cnu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31409648

Citation

Lee, Min Woo, et al. "Longitudinal Changes in Axial Length in High Myopia: a 4-year Prospective Study." The British Journal of Ophthalmology, 2019.
Lee MW, Lee SE, Lim HB, et al. Longitudinal changes in axial length in high myopia: a 4-year prospective study. Br J Ophthalmol. 2019.
Lee, M. W., Lee, S. E., Lim, H. B., & Kim, J. Y. (2019). Longitudinal changes in axial length in high myopia: a 4-year prospective study. The British Journal of Ophthalmology, doi:10.1136/bjophthalmol-2019-314619.
Lee MW, et al. Longitudinal Changes in Axial Length in High Myopia: a 4-year Prospective Study. Br J Ophthalmol. 2019 Aug 13; PubMed PMID: 31409648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal changes in axial length in high myopia: a 4-year prospective study. AU - Lee,Min Woo, AU - Lee,Seong-Eun, AU - Lim,Hyung-Bin, AU - Kim,Jung-Yeul, Y1 - 2019/08/13/ PY - 2019/05/22/received PY - 2019/06/25/revised PY - 2019/07/30/accepted PY - 2019/8/15/entrez KW - axial length KW - high myopia JF - The British journal of ophthalmology JO - Br J Ophthalmol N2 - AIM: To determine the longitudinal changes in the axial length (AL) in patients with high myopia without any other ophthalmic disease METHODS: Participants were divided into two groups: a high myopia group (60 eyes) without myopic degeneration, such as chorioretinal atrophy or posterior staphyloma, and a control group (60 eyes). Both groups were further divided into subgroups according to the AL: subgroup 1 (≥27.5 mm), subgroup 2 (26.0-27.5 mm), subgroup 3 (24.5-26.0 mm) and subgroup 4 (<24.5 mm). The ALs were measured five times at 1-year interval using an IOL master, and the AL was fitted with linear mixed models. RESULTS: In the high myopia group, the AL showed a relatively constant increase at each visit, and they were significantly different with previous measurements at most visits, whereas the control group showed no significant change of AL. Subgroups 1,2 and 3 showed significant changes in AL over time (0.064, 0.032 and 0.012 mm/y, respectively). In univariate analyses, age, best-corrected visual acuity, baseline AL and anterior chamber depth were significantly correlated with changes in the AL in the high myopia group. In multivariate analysis, only baseline AL remained significant (p<0.001). CONCLUSIONS: Myopic eyes, including moderately myopic eyes, showed a consistent increase in AL over 4 years, and eyes with a longer baseline AL showed a greater increase in AL than eyes with a shorter AL. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/31409648/Longitudinal_changes_in_axial_length_in_high_myopia:_a_4-year_prospective_study L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&amp;pmid=31409648 DB - PRIME DP - Unbound Medicine ER -