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The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response.
Acta Naturae 2019 Apr-Jun; 11(2):63-67AN

Abstract

Cyclophilin A (CypA) is a multifunctional protein that exhibits an isomerase activity and exists in the intracellular and secretory forms. Secretory CypA promotes regeneration of the hematopoietic and the immune systems of an organism by stimulating stem cell migration from the bone marrow. New approaches based on CypA are currently being developed for the treatment of limb ischemia, neutralization of the side effects of Cyclosporine A (CsA) therapy, etc. However, the role of CypA in the antitumor immune response is still unexplored. In this work, we used the model experimental system of lymphoma EL-4 rejection in B10.D2(R101) mice and showed that recombinant human CypA (rhCypA) stimulates the antitumor immune response via early recruitment of granulocytes to the tumor cell localization site and rapid accumulation of effector T-killers.

Authors+Show Affiliations

Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Kashirskoye Sh. 24, Moscow, 115478, Russia.Federal State Budget Institution of Sciences «Institute of Gene Biology» Russian Academy of Sciences, Vavilova Str. 34/5, Moscow, 119334, Russia.Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Kashirskoye Sh. 24, Moscow, 115478, Russia.Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Kashirskoye Sh. 24, Moscow, 115478, Russia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31413881

Citation

Kalinina, A A., et al. "The Role of Recombinant Human Cyclophilin a in the Antitumor Immune Response." Acta Naturae, vol. 11, no. 2, 2019, pp. 63-67.
Kalinina AA, Silaeva YY, Kazansky DB, et al. The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response. Acta Naturae. 2019;11(2):63-67.
Kalinina, A. A., Silaeva, Y. Y., Kazansky, D. B., & Khromykh, L. M. (2019). The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response. Acta Naturae, 11(2), pp. 63-67. doi:10.32607/20758251-2019-11-2-63-67.
Kalinina AA, et al. The Role of Recombinant Human Cyclophilin a in the Antitumor Immune Response. Acta Naturae. 2019;11(2):63-67. PubMed PMID: 31413881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response. AU - Kalinina,A A, AU - Silaeva,Yu Yu, AU - Kazansky,D B, AU - Khromykh,L M, PY - 2019/8/16/entrez PY - 2019/8/16/pubmed PY - 2019/8/16/medline KW - Cyclophilin A KW - T-cell receptor KW - antitumor immune response KW - pro-inflammatory factor KW - transgenic mice SP - 63 EP - 67 JF - Acta naturae JO - Acta Naturae VL - 11 IS - 2 N2 - Cyclophilin A (CypA) is a multifunctional protein that exhibits an isomerase activity and exists in the intracellular and secretory forms. Secretory CypA promotes regeneration of the hematopoietic and the immune systems of an organism by stimulating stem cell migration from the bone marrow. New approaches based on CypA are currently being developed for the treatment of limb ischemia, neutralization of the side effects of Cyclosporine A (CsA) therapy, etc. However, the role of CypA in the antitumor immune response is still unexplored. In this work, we used the model experimental system of lymphoma EL-4 rejection in B10.D2(R101) mice and showed that recombinant human CypA (rhCypA) stimulates the antitumor immune response via early recruitment of granulocytes to the tumor cell localization site and rapid accumulation of effector T-killers. SN - 2075-8251 UR - https://www.unboundmedicine.com/medline/citation/31413881/The_Role_of_Recombinant_Human_Cyclophilin_A_in_the_Antitumor_Immune_Response L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31413881/ DB - PRIME DP - Unbound Medicine ER -