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Trajectories of Fetal Adipose Tissue Thickness in Pregnancies After Gastric Bypass Surgery.
Obes Surg. 2020 01; 30(1):96-101.OS

Abstract

PURPOSE

Recent studies showed that women after surgery are at higher risk of delivering small-for-gestational infants. Thus, this study aims to investigate longitudinal changes of fetal subcutaneous adipose tissue thickness (FSCTT) of fetuses conceived after gastric bypass surgery as compared to BMI-matched controls.

METHODS

Retrospective cohort study measuring ultrasound-derived longitudinal trajectories of abdominal FSCTT in 41 singleton pregnancies after gastric bypass surgery compared to 41 BMI-matched controls and 64 obese mothers.

RESULTS

FSCTT was significantly lower in fetuses of women after GB as compared to BMI-matched controls in the second (mean difference 1.38 mm, p < 0.001) and third trimester of gestation (mean difference 3.37 mm, p < 0.001). Longitudinal analysis revealed significant differences in mean FSCTT trajectories between offspring's in GB mothers, BMI-matched, or obese controls. The ratio of FSCTT and abdominal circumference remained constant in the BMI-matched control group whereas it significantly decreased in fetuses of women after GB. Despite remarkable differences were observed in longitudinally assessed FSCTT, further analyses in the GB subgroup revealed that FSCTT were not influenced by OGTT mean or 120 min glucose values, biochemically hypoglycemia, time since bariatric surgery, or weight loss since surgery.

CONCLUSION

In fetuses of mothers with history of bariatric surgery, abdominal FSCTT was markedly reduced. While the underlying mechanisms are not fully understood, a multifactorial genesis including nutritional deficiencies and altered metabolism after bariatric surgery is assumed.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria. Wunschbaby Institut Feichtinger, Vienna, Austria.Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.Department of Obstetrics and Gynaecology, University Hospital Basel, Basel, Switzerland.Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.Department of Obstetrics and Gynaecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria. christian.goebl@meduniwien.ac.at.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31414296

Citation

Yerlikaya-Schatten, Gülen, et al. "Trajectories of Fetal Adipose Tissue Thickness in Pregnancies After Gastric Bypass Surgery." Obesity Surgery, vol. 30, no. 1, 2020, pp. 96-101.
Yerlikaya-Schatten G, Feichtinger M, Stopp T, et al. Trajectories of Fetal Adipose Tissue Thickness in Pregnancies After Gastric Bypass Surgery. Obes Surg. 2020;30(1):96-101.
Yerlikaya-Schatten, G., Feichtinger, M., Stopp, T., Huhn, E. A., Chalubinski, K., Husslein, P., Eppel, W., Schatten, C., & Göbl, C. S. (2020). Trajectories of Fetal Adipose Tissue Thickness in Pregnancies After Gastric Bypass Surgery. Obesity Surgery, 30(1), 96-101. https://doi.org/10.1007/s11695-019-04115-9
Yerlikaya-Schatten G, et al. Trajectories of Fetal Adipose Tissue Thickness in Pregnancies After Gastric Bypass Surgery. Obes Surg. 2020;30(1):96-101. PubMed PMID: 31414296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trajectories of Fetal Adipose Tissue Thickness in Pregnancies After Gastric Bypass Surgery. AU - Yerlikaya-Schatten,Gülen, AU - Feichtinger,Michael, AU - Stopp,Tina, AU - Huhn,Evelyn A, AU - Chalubinski,Kinga, AU - Husslein,Peter, AU - Eppel,Wolfgang, AU - Schatten,Christian, AU - Göbl,Christian S, PY - 2019/8/16/pubmed PY - 2020/8/28/medline PY - 2019/8/16/entrez KW - Bariatric surgery KW - Fat tissue KW - Fetus KW - Gestational diabetes KW - Growth restriction KW - OGTT SP - 96 EP - 101 JF - Obesity surgery JO - Obes Surg VL - 30 IS - 1 N2 - PURPOSE: Recent studies showed that women after surgery are at higher risk of delivering small-for-gestational infants. Thus, this study aims to investigate longitudinal changes of fetal subcutaneous adipose tissue thickness (FSCTT) of fetuses conceived after gastric bypass surgery as compared to BMI-matched controls. METHODS: Retrospective cohort study measuring ultrasound-derived longitudinal trajectories of abdominal FSCTT in 41 singleton pregnancies after gastric bypass surgery compared to 41 BMI-matched controls and 64 obese mothers. RESULTS: FSCTT was significantly lower in fetuses of women after GB as compared to BMI-matched controls in the second (mean difference 1.38 mm, p < 0.001) and third trimester of gestation (mean difference 3.37 mm, p < 0.001). Longitudinal analysis revealed significant differences in mean FSCTT trajectories between offspring's in GB mothers, BMI-matched, or obese controls. The ratio of FSCTT and abdominal circumference remained constant in the BMI-matched control group whereas it significantly decreased in fetuses of women after GB. Despite remarkable differences were observed in longitudinally assessed FSCTT, further analyses in the GB subgroup revealed that FSCTT were not influenced by OGTT mean or 120 min glucose values, biochemically hypoglycemia, time since bariatric surgery, or weight loss since surgery. CONCLUSION: In fetuses of mothers with history of bariatric surgery, abdominal FSCTT was markedly reduced. While the underlying mechanisms are not fully understood, a multifactorial genesis including nutritional deficiencies and altered metabolism after bariatric surgery is assumed. SN - 1708-0428 UR - https://www.unboundmedicine.com/medline/citation/31414296/Trajectories_of_Fetal_Adipose_Tissue_Thickness_in_Pregnancies_After_Gastric_Bypass_Surgery_ L2 - https://dx.doi.org/10.1007/s11695-019-04115-9 DB - PRIME DP - Unbound Medicine ER -