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Physiological status of silver carp (Hypophthalmichthys molitrix) in the Illinois River: An assessment of fish at the leading edge of the invasion front.

Abstract

Silver carp (Hypophthalmichthys molitrix) are invasive to North America, and their range has expanded within the Mississippi River Basin, seemingly unchecked, since their introduction in the late 1970s, with the exception of the upper reaches of the Illinois River. With the imminent threat of their movement into the Great Lakes, the goal of the present study was to assess whether differences in the physiological status between silver carp at the leading edge of their invasion front and core population sites could explain their lack of expansion upstream toward Lake Michigan over the past decade. A transcriptomic approach using RNA sequencing and analysis of plasma variables were used to quantify differences among fish at the leading edge and two downstream core population sites. Leading-edge fish exhibited upregulation of genes associated with xenobiotic defense (e.g., ATP-binding cassette C1 [abcc1], abcc2, abcc6), decreased cell integrity (i.e., macroautophagy and apoptosis; autophagy-related protein 9A [atg9a], caspase 3b [casp3b]), and cholesterol metabolism (e.g., abca1, apolipoprotein A1 [apoa1], sterol O-acyltransferase [soat1]) and downregulation of genes associated with DNA repair (e.g., tumor suppressor p53-binding protein 1 [tp53bp1]) compared to core population sites. Transcriptomic profiles of leading-edge fish were consistent with fish inhabiting a polluted environment and suggest that poorer water quality conditions upstream of the leading edge may represent a non-permanent barrier to silver carp range expansion. The present study provides potential molecular targets for monitoring the physiological status of silver carp over time and in response to future improvements in water quality upstream of their leading edge.

Authors+Show Affiliations

Department of Natural Resources and Environmental Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Electronic address: jenjeffrey@gmail.com.Department of Biology, University of Manitoba, Winnipeg, Manitoba, Canada.Department of Natural Resources and Environmental Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

31419603

Citation

Jeffrey, Jennifer D., et al. "Physiological Status of Silver Carp (Hypophthalmichthys Molitrix) in the Illinois River: an Assessment of Fish at the Leading Edge of the Invasion Front." Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics, vol. 32, 2019, p. 100614.
Jeffrey JD, Jeffries KM, Suski CD. Physiological status of silver carp (Hypophthalmichthys molitrix) in the Illinois River: An assessment of fish at the leading edge of the invasion front. Comp Biochem Physiol Part D Genomics Proteomics. 2019;32:100614.
Jeffrey, J. D., Jeffries, K. M., & Suski, C. D. (2019). Physiological status of silver carp (Hypophthalmichthys molitrix) in the Illinois River: An assessment of fish at the leading edge of the invasion front. Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics, 32, 100614. https://doi.org/10.1016/j.cbd.2019.100614
Jeffrey JD, Jeffries KM, Suski CD. Physiological Status of Silver Carp (Hypophthalmichthys Molitrix) in the Illinois River: an Assessment of Fish at the Leading Edge of the Invasion Front. Comp Biochem Physiol Part D Genomics Proteomics. 2019;32:100614. PubMed PMID: 31419603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiological status of silver carp (Hypophthalmichthys molitrix) in the Illinois River: An assessment of fish at the leading edge of the invasion front. AU - Jeffrey,Jennifer D, AU - Jeffries,Ken M, AU - Suski,Cory D, Y1 - 2019/07/29/ PY - 2019/03/19/received PY - 2019/07/08/revised PY - 2019/07/24/accepted PY - 2019/8/17/pubmed PY - 2020/4/3/medline PY - 2019/8/17/entrez KW - Contaminants KW - Distribution KW - Invasive species KW - Liver KW - RNA-seq KW - Range expansion KW - Teleost SP - 100614 EP - 100614 JF - Comparative biochemistry and physiology. Part D, Genomics & proteomics JO - Comp. Biochem. Physiol. Part D Genomics Proteomics VL - 32 N2 - Silver carp (Hypophthalmichthys molitrix) are invasive to North America, and their range has expanded within the Mississippi River Basin, seemingly unchecked, since their introduction in the late 1970s, with the exception of the upper reaches of the Illinois River. With the imminent threat of their movement into the Great Lakes, the goal of the present study was to assess whether differences in the physiological status between silver carp at the leading edge of their invasion front and core population sites could explain their lack of expansion upstream toward Lake Michigan over the past decade. A transcriptomic approach using RNA sequencing and analysis of plasma variables were used to quantify differences among fish at the leading edge and two downstream core population sites. Leading-edge fish exhibited upregulation of genes associated with xenobiotic defense (e.g., ATP-binding cassette C1 [abcc1], abcc2, abcc6), decreased cell integrity (i.e., macroautophagy and apoptosis; autophagy-related protein 9A [atg9a], caspase 3b [casp3b]), and cholesterol metabolism (e.g., abca1, apolipoprotein A1 [apoa1], sterol O-acyltransferase [soat1]) and downregulation of genes associated with DNA repair (e.g., tumor suppressor p53-binding protein 1 [tp53bp1]) compared to core population sites. Transcriptomic profiles of leading-edge fish were consistent with fish inhabiting a polluted environment and suggest that poorer water quality conditions upstream of the leading edge may represent a non-permanent barrier to silver carp range expansion. The present study provides potential molecular targets for monitoring the physiological status of silver carp over time and in response to future improvements in water quality upstream of their leading edge. SN - 1878-0407 UR - https://www.unboundmedicine.com/medline/citation/31419603/Physiological_status_of_silver_carp__Hypophthalmichthys_molitrix__in_the_Illinois_River:_An_assessment_of_fish_at_the_leading_edge_of_the_invasion_front_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1744-117X(19)30143-1 DB - PRIME DP - Unbound Medicine ER -