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Colorectal Adenocarcinoma: Imaging using 5-Fluoracil Nanoparticles Labeled with Technetium 99 Metastable.

Abstract

Adenocarcinoma of colon and rectum are one of the most common cancers worldwide, responsible for over 1,300,000 people diagnosed. Also, they are responsible for metastasis, which leads to death in less than 5 years. In this study, we developed, characterized and pre-clinically test a new nano-radiopharmaceutical for early and differential detection of adenocarcinoma of colon and rectum. Results demonstrated the specificity of the developed nano system and the ability to reach tumor with very specific targeting. Also the imaging data support the use of this nano-agent as a nano-imaging-guided-radiopharmaceutical.

Authors+Show Affiliations

Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro,. Brazil.Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro,. Brazil.Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro,. Brazil.Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro,. Brazil.Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro,. Brazil.Federal University of Maranhão, Department of Physics, São Luis, Maranhão,. Brazil.Zona Oeste State University, Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Rio de Janeiro,. Brazil.Brazilian Nuclear Energy Commission Nuclear Engineering Institute Rio de Janeiro,. Brazil.Zona Oeste State University, Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Rio de Janeiro,. Brazil.Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Rio de Janeiro,. Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31419931

Citation

de Almeida, Julio Cesar, et al. "Colorectal Adenocarcinoma: Imaging Using 5-Fluoracil Nanoparticles Labeled With Technetium 99 Metastable." Current Pharmaceutical Design, 2019.
de Almeida JC, Helal-Neto E, Pinto SR, et al. Colorectal Adenocarcinoma: Imaging using 5-Fluoracil Nanoparticles Labeled with Technetium 99 Metastable. Curr Pharm Des. 2019.
de Almeida, J. C., Helal-Neto, E., Pinto, S. R., Dos Santos, S. N., Bernardes, E. S., Al-Qahtani, M., ... Santos-Oliveira, R. (2019). Colorectal Adenocarcinoma: Imaging using 5-Fluoracil Nanoparticles Labeled with Technetium 99 Metastable. Current Pharmaceutical Design, doi:10.2174/1381612825666190816235147.
de Almeida JC, et al. Colorectal Adenocarcinoma: Imaging Using 5-Fluoracil Nanoparticles Labeled With Technetium 99 Metastable. Curr Pharm Des. 2019 Aug 16; PubMed PMID: 31419931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Colorectal Adenocarcinoma: Imaging using 5-Fluoracil Nanoparticles Labeled with Technetium 99 Metastable. AU - de Almeida,Julio Cesar, AU - Helal-Neto,Edward, AU - Pinto,Suyene Rocha, AU - Dos Santos,Sofia Nascimento, AU - Bernardes,Emerson Soares, AU - Al-Qahtani,Mohammed, AU - Nigro,Fiammetta, AU - Alencar,Luciana Magalhaes Rebelo, AU - Ricci-Junior,Eduardo, AU - Santos-Oliveira,Ralph, Y1 - 2019/08/16/ PY - 2019/01/08/received PY - 2019/07/06/revised PY - 2019/08/06/accepted PY - 2019/8/18/entrez KW - polymeric nanoparticles; adenocarcinoma; cancer; imaging; nano-radiopharmaceutical; radiopharmacy JF - Current pharmaceutical design JO - Curr. Pharm. Des. N2 - Adenocarcinoma of colon and rectum are one of the most common cancers worldwide, responsible for over 1,300,000 people diagnosed. Also, they are responsible for metastasis, which leads to death in less than 5 years. In this study, we developed, characterized and pre-clinically test a new nano-radiopharmaceutical for early and differential detection of adenocarcinoma of colon and rectum. Results demonstrated the specificity of the developed nano system and the ability to reach tumor with very specific targeting. Also the imaging data support the use of this nano-agent as a nano-imaging-guided-radiopharmaceutical. SN - 1873-4286 UR - https://www.unboundmedicine.com/medline/citation/31419931/Colorectal_Adenocarcinoma:_Imaging_using_5-Fluoracil_Nanoparticles_Labeled_with_Technetium_99_Metastable L2 - https://www.ingentaconnect.com/content/10.2174/1381612825666190816235147 DB - PRIME DP - Unbound Medicine ER -