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[DNCB therapy of alopecia areata].
Z Hautkr. 1979 May 15; 54(10):426-9.ZH

Abstract

Long-term treatment of alopecia areata with dinitrochlorobenzene is effective. During the last two and a half years, 227 patients who suffered, in the majority of cases, from total or subtotal hair loss, were treated by this method. Unilateral application of DNCB induced unilateral regrowth of hair in 88% of these patients. Under continuous treatment of both sides of the head, this initial response was followed by complete regrowth of hair in 78%. The same result could be obtained by application of squaric acid dibutylester, another potent contact allergen. This indicates that the essential mechanism is contact allergy. Possibly, the regrowth of hair is due to the induction of local nonspecific immunosuppression.

Authors

Happle R
No affiliation info available

MeSH

Alopecia AreataAutoimmune DiseasesBinding, CompetitiveCyclobutanesDinitrochlorobenzeneHumansImmunosuppression TherapyNitrobenzenesT-Lymphocytes

Pub Type(s)

Journal Article

Language

ger

PubMed ID

314203

Citation

Happle, R. "[DNCB Therapy of Alopecia Areata]." Zeitschrift Fur Hautkrankheiten, vol. 54, no. 10, 1979, pp. 426-9.
Happle R. [DNCB therapy of alopecia areata]. Z Hautkr. 1979;54(10):426-9.
Happle, R. (1979). [DNCB therapy of alopecia areata]. Zeitschrift Fur Hautkrankheiten, 54(10), 426-9.
Happle R. [DNCB Therapy of Alopecia Areata]. Z Hautkr. 1979 May 15;54(10):426-9. PubMed PMID: 314203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [DNCB therapy of alopecia areata]. A1 - Happle,R, PY - 1979/5/15/pubmed PY - 1979/5/15/medline PY - 1979/5/15/entrez SP - 426 EP - 9 JF - Zeitschrift fur Hautkrankheiten JO - Z Hautkr VL - 54 IS - 10 N2 - Long-term treatment of alopecia areata with dinitrochlorobenzene is effective. During the last two and a half years, 227 patients who suffered, in the majority of cases, from total or subtotal hair loss, were treated by this method. Unilateral application of DNCB induced unilateral regrowth of hair in 88% of these patients. Under continuous treatment of both sides of the head, this initial response was followed by complete regrowth of hair in 78%. The same result could be obtained by application of squaric acid dibutylester, another potent contact allergen. This indicates that the essential mechanism is contact allergy. Possibly, the regrowth of hair is due to the induction of local nonspecific immunosuppression. SN - 0301-0481 UR - https://www.unboundmedicine.com/medline/citation/314203/[DNCB_therapy_of_alopecia_areata]_ L2 - https://www.diseaseinfosearch.org/result/313 DB - PRIME DP - Unbound Medicine ER -