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Kinins in Glioblastoma Microenvironment.

Abstract

Tumour progression involves interactions among various cancer cell clones, including the cancer stem cell subpopulation and exogenous cellular components, termed cancer stromal cells. The latter include a plethora of tumour infiltrating immunocompetent cells, among which are also immuno-modulatory mesenchymal stem cells, which by vigorous migration to growing tumours and susequent transdifferentiation into various types of tumour-residing stromal cells, may either inhibit or support tumour progression. In the light of the scarce therapeutic options existing for the most malignant brain tumour glioblastoma, mesenchymal stem cells may represent a promising novel tool for cell therapy, e.g. drug delivery vectors. Here, we review the increasing number of reports on mutual interactions between mesenchymal stem cells and glioblastoma cells in their microenvironment. We particularly point out two novel aspects: the different responses of cancer cells to their microenvironmental cues, and to the signalling by kinin receptors that complement the immuno-modulating cytokine-signalling networks. Inflammatory glioblastoma microenvironment is characterised by increasing expression of kinin receptors during progressive glioma malignancy, thus making kinin signalling and kinins themselves rather important in this context. In general, their role in tumour microenvironment has not been explored so far. In addition, kinins also regulate blood brain barrier-related drug transfer as well as brain tumour angiogenesis. These studies support the on-going research on kinin antagonists as candidates in the development of anti-invasive agents for adjuvant glioblastoma therapy.

Authors+Show Affiliations

Department of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineus Prestes 748, São Paulo, SP, 05508-000, Brazil. Jožef Stefan International Postgraduate School, Jamova, 39 1000, Ljubljana, Slovenia.Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna pot 111, 1000, Ljubljana, Slovenia. barbara.breznik@nib.si.Department of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineus Prestes 748, São Paulo, SP, 05508-000, Brazil.Department of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineus Prestes 748, São Paulo, SP, 05508-000, Brazil.Department of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineus Prestes 748, São Paulo, SP, 05508-000, Brazil.Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna pot 111, 1000, Ljubljana, Slovenia. Department of Biochemistry, Faculty of Chemistry and Chemical Engineering, University of Ljubljana, Večna pot 113, 1000, Ljubljana, Slovenia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31420805

Citation

Oliveira, Mona N., et al. "Kinins in Glioblastoma Microenvironment." Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society, 2019.
Oliveira MN, Breznik B, Pillat MM, et al. Kinins in Glioblastoma Microenvironment. Cancer Microenviron. 2019.
Oliveira, M. N., Breznik, B., Pillat, M. M., Pereira, R. L., Ulrich, H., & Lah, T. T. (2019). Kinins in Glioblastoma Microenvironment. Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society, doi:10.1007/s12307-019-00229-x.
Oliveira MN, et al. Kinins in Glioblastoma Microenvironment. Cancer Microenviron. 2019 Aug 16; PubMed PMID: 31420805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinins in Glioblastoma Microenvironment. AU - Oliveira,Mona N, AU - Breznik,Barbara, AU - Pillat,Micheli M, AU - Pereira,Ricardo L, AU - Ulrich,Henning, AU - Lah,Tamara T, Y1 - 2019/08/16/ PY - 2019/04/16/received PY - 2019/07/29/accepted PY - 2019/8/18/entrez KW - Co-culture KW - Glioma KW - Kinin receptors KW - Mesenchymal stem cells KW - Microenvironment KW - Tumour heterogeneity JF - Cancer microenvironment : official journal of the International Cancer Microenvironment Society JO - Cancer Microenviron N2 - Tumour progression involves interactions among various cancer cell clones, including the cancer stem cell subpopulation and exogenous cellular components, termed cancer stromal cells. The latter include a plethora of tumour infiltrating immunocompetent cells, among which are also immuno-modulatory mesenchymal stem cells, which by vigorous migration to growing tumours and susequent transdifferentiation into various types of tumour-residing stromal cells, may either inhibit or support tumour progression. In the light of the scarce therapeutic options existing for the most malignant brain tumour glioblastoma, mesenchymal stem cells may represent a promising novel tool for cell therapy, e.g. drug delivery vectors. Here, we review the increasing number of reports on mutual interactions between mesenchymal stem cells and glioblastoma cells in their microenvironment. We particularly point out two novel aspects: the different responses of cancer cells to their microenvironmental cues, and to the signalling by kinin receptors that complement the immuno-modulating cytokine-signalling networks. Inflammatory glioblastoma microenvironment is characterised by increasing expression of kinin receptors during progressive glioma malignancy, thus making kinin signalling and kinins themselves rather important in this context. In general, their role in tumour microenvironment has not been explored so far. In addition, kinins also regulate blood brain barrier-related drug transfer as well as brain tumour angiogenesis. These studies support the on-going research on kinin antagonists as candidates in the development of anti-invasive agents for adjuvant glioblastoma therapy. SN - 1875-2292 UR - https://www.unboundmedicine.com/medline/citation/31420805/Kinins_in_Glioblastoma_Microenvironment L2 - https://dx.doi.org/10.1007/s12307-019-00229-x DB - PRIME DP - Unbound Medicine ER -