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Second-line treatment with lesinurad and allopurinol versus febuxostat for management of hyperuricemia: a cost-effectiveness analysis for Spanish patients.

Abstract

INTRODUCTION/OBJECTIVES

Lesinurad, in combination with allopurinol, has been approved for treatment of patients with gout which do not reach therapeutic serum urate target with xanthine oxidase inhibitors monotherapy. The study aimed to assess the incremental cost-effectiveness ratio of adding lesinurad to allopurinol as second-line therapy, compared to febuxostat for patients with gout in Spain.

METHOD

A Markov model representing disease evolution was used to estimate the lifetime accumulated cost and benefits in terms of quality-adjusted-life-year (QALY). Patients could either continue with second-line treatment with lesinurad (200 mg/daily) plus allopurinol (400 mg/daily) or febuxostat (80 mg/daily) switch to allopurinol monotherapy (271 mg/daily) in case of intolerance or discontinue treatment. The treatment's efficacy captured in the transition probabilities between health states were derived from CLEAR and EXCEL trials. Quality of life related to gout severity and flare frequency was considered by means of utilities. The total cost estimation (€, 2019) included drug acquisition cost, disease monitoring, and flare management cost. Unitary local costs derived from databases and literature. A 3% annual discount rate was applied for cost and outcomes.

RESULTS

Lesinurad plus allopurinol provided higher QALYs (14.79) than febuxostat (14.69). Total accrued cost/patient was lower with lesinurad and allopurinol (€50,631.51) versus febuxostat (€56,698.64). Lesinurad plus allopurinol resulted more effective and less costly (dominant option) versus febuxostat.

CONCLUSIONS

Lesinurad plus allopurinol therapy compared with febuxostat seems an effective option for the management of hyperuricemia in patients who did not reach serum urate target to previous allopurinol monotherapy, associated to cost-savings for the Spanish Health System. Key Points • Lesinurad, in combination with allopurinol, has been recently authorized as second-line treatment of hyperuricemia in gout patients. • Lesinurad plus allopurinol provided higher effectiveness in terms of quality-adjusted-life-years (14.79) than febuxostat (14.69). • Lesinurad plus allopurinol resulted less costly (total cost/per patient) compared with febuxostat. • Lesinurad plus allopurinol resulted a dominant option compared with febuxostat.

Authors+Show Affiliations

Pharmacoeconomics & Outcomes Research Iberia (PORIB), Paseo Joaquín Rodrigo, 4 letra I, 28224, Pozuelo de Alarcón, Madrid, Spain. mpresa@porib.com.Department of Medicine, Medicine and Nursery School, University of the Basque Country, Vizcaya, Spain.Pharmacoeconomics & Outcomes Research Iberia (PORIB), Paseo Joaquín Rodrigo, 4 letra I, 28224, Pozuelo de Alarcón, Madrid, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31420811

Citation

Presa, María, et al. "Second-line Treatment With Lesinurad and Allopurinol Versus Febuxostat for Management of Hyperuricemia: a Cost-effectiveness Analysis for Spanish Patients." Clinical Rheumatology, 2019.
Presa M, Pérez-Ruiz F, Oyagüez I. Second-line treatment with lesinurad and allopurinol versus febuxostat for management of hyperuricemia: a cost-effectiveness analysis for Spanish patients. Clin Rheumatol. 2019.
Presa, M., Pérez-Ruiz, F., & Oyagüez, I. (2019). Second-line treatment with lesinurad and allopurinol versus febuxostat for management of hyperuricemia: a cost-effectiveness analysis for Spanish patients. Clinical Rheumatology, doi:10.1007/s10067-019-04739-3.
Presa M, Pérez-Ruiz F, Oyagüez I. Second-line Treatment With Lesinurad and Allopurinol Versus Febuxostat for Management of Hyperuricemia: a Cost-effectiveness Analysis for Spanish Patients. Clin Rheumatol. 2019 Aug 16; PubMed PMID: 31420811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Second-line treatment with lesinurad and allopurinol versus febuxostat for management of hyperuricemia: a cost-effectiveness analysis for Spanish patients. AU - Presa,María, AU - Pérez-Ruiz,Fernando, AU - Oyagüez,Itziar, Y1 - 2019/08/16/ PY - 2019/06/10/received PY - 2019/08/04/accepted PY - 2019/06/10/revised PY - 2019/8/18/entrez KW - Cost KW - Cost-effectiveness KW - Gout KW - Hyperuricemia KW - Lesinurad/allopurinol KW - Spain JF - Clinical rheumatology JO - Clin. Rheumatol. N2 - INTRODUCTION/OBJECTIVES: Lesinurad, in combination with allopurinol, has been approved for treatment of patients with gout which do not reach therapeutic serum urate target with xanthine oxidase inhibitors monotherapy. The study aimed to assess the incremental cost-effectiveness ratio of adding lesinurad to allopurinol as second-line therapy, compared to febuxostat for patients with gout in Spain. METHOD: A Markov model representing disease evolution was used to estimate the lifetime accumulated cost and benefits in terms of quality-adjusted-life-year (QALY). Patients could either continue with second-line treatment with lesinurad (200 mg/daily) plus allopurinol (400 mg/daily) or febuxostat (80 mg/daily) switch to allopurinol monotherapy (271 mg/daily) in case of intolerance or discontinue treatment. The treatment's efficacy captured in the transition probabilities between health states were derived from CLEAR and EXCEL trials. Quality of life related to gout severity and flare frequency was considered by means of utilities. The total cost estimation (€, 2019) included drug acquisition cost, disease monitoring, and flare management cost. Unitary local costs derived from databases and literature. A 3% annual discount rate was applied for cost and outcomes. RESULTS: Lesinurad plus allopurinol provided higher QALYs (14.79) than febuxostat (14.69). Total accrued cost/patient was lower with lesinurad and allopurinol (€50,631.51) versus febuxostat (€56,698.64). Lesinurad plus allopurinol resulted more effective and less costly (dominant option) versus febuxostat. CONCLUSIONS: Lesinurad plus allopurinol therapy compared with febuxostat seems an effective option for the management of hyperuricemia in patients who did not reach serum urate target to previous allopurinol monotherapy, associated to cost-savings for the Spanish Health System. Key Points • Lesinurad, in combination with allopurinol, has been recently authorized as second-line treatment of hyperuricemia in gout patients. • Lesinurad plus allopurinol provided higher effectiveness in terms of quality-adjusted-life-years (14.79) than febuxostat (14.69). • Lesinurad plus allopurinol resulted less costly (total cost/per patient) compared with febuxostat. • Lesinurad plus allopurinol resulted a dominant option compared with febuxostat. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/31420811/Second-line_treatment_with_lesinurad_and_allopurinol_versus_febuxostat_for_management_of_hyperuricemia:_a_cost-effectiveness_analysis_for_Spanish_patients L2 - https://dx.doi.org/10.1007/s10067-019-04739-3 DB - PRIME DP - Unbound Medicine ER -